MALT is a paracaspase that belongs to the family of proteases known as caspase (cysteine-aspartic proteases), but it cleaves after Arg residues rather than Asp. The pathogenesis of DLBCL's chemoresistant variant, activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), is associated with MALT cleavage activity. In ABC-DLBCL, MALT is a special paracaspase protein that transmits aberrant oncogenic signaling. A significant therapeutic target for ABC-DLBCL and MALT lymphoma is MALT. MALT small molecule inhibitors may be helpful chemical tools for figuring out the biology of MALT1 and treating tumors that are dependent on MALT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1928 | MI-2 (MALT1 inhibitor) | 1047953-91-2 | MI-2 (also known as MALT1 inhibitor) is a potent and irreversible MALT1 inhibitor with IC50 of 5.84 μM, andbinds directly to MALT1, irreversibly suppresses protease function. |