MALT is a paracaspase that belongs to the family of proteases known as caspase (cysteine-aspartic proteases), but it cleaves after Arg residues rather than Asp. The pathogenesis of DLBCL's chemoresistant variant, activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), is associated with MALT cleavage activity. In ABC-DLBCL, MALT is a special paracaspase protein that transmits aberrant oncogenic signaling. A significant therapeutic target for ABC-DLBCL and MALT lymphoma is MALT. MALT small molecule inhibitors may be helpful chemical tools for figuring out the biology of MALT1 and treating tumors that are dependent on MALT.