MALT

MALT

MALT is a paracaspase that belongs to the family of proteases known as caspase (cysteine-aspartic proteases), but it cleaves after Arg residues rather than Asp. The pathogenesis of DLBCL's chemoresistant variant, activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), is associated with MALT cleavage activity. In ABC-DLBCL, MALT is a special paracaspase protein that transmits aberrant oncogenic signaling. A significant therapeutic target for ABC-DLBCL and MALT lymphoma is MALT. MALT small molecule inhibitors may be helpful chemical tools for figuring out the biology of MALT1 and treating tumors that are dependent on MALT.

MALT related products

Structure Cat No. Product Name CAS No. Product Description
V1928 MI-2 (MALT1 inhibitor) 1047953-91-2 MI-2 (also known as MALT1 inhibitor) is a potent and irreversible MALT1 inhibitor with IC50 of 5.84 μM, andbinds directly to MALT1, irreversibly suppresses protease function.
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