In the central nervous system (CNS) of vertebrates, dopamine receptors are a class of G protein-coupled receptors that are widely distributed. The main endogenous ligand for dopamine receptors is the neurotransmitter dopamine. Numerous neurological functions, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as the modulation of neuroendocrine signaling, are associated with dopamine receptors. Numerous neuropsychiatric disorders have abnormal dopamine receptor signaling and dopaminergic nerve function at their core.Dopamine receptors are therefore typical neurologic drug targets; psychostimulants are typically indirect agonists of dopamine receptors, whereas antipsychotics are frequently dopamine receptor antagonists. Dopamine receptors come in at least five different subtypes: D1, D2, D3, D4, and D5. The D2, D3, and D4 dopamine receptors are members of the D2-like family, whereas the D1 and D5 receptors belong to the D1-like family.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V7444 | 6-OHDA HBr (Oxidopamine hydrobromide) | 636-00-0 | Oxidopamine (6-OHDA) HBr is an antagonist of the neurotransmitter dopamine. |
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V17025 | Brexpiprazole | 913611-97-9 | Brexpiprazole (formerlyOPC-34712;OPC34712; Rexulti)is a novel D2 dopamine partial agonist [also called serotonin-dopamine activity modulator (SDAM)] approved asanatypical antipsychotic drug. |
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V3672 | Diclofensine HCl | 34041-84-4 | Diclofensine HCl salt (also known as Ro-8-4650 HCl) is a novel and potent inhibitor of monoamine reuptake which blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. |
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V20819 | Etilevodopa | 37178-37-3 | Etilevodopa (TV-1203; Levodopa ethyl ester;L-Dopa ethyl ester; O-Ethyl-DOPA) is a dopaminergic agent used for the treatment for Parkinsons disease. |
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V20820 | Etilevodopa HCl | 39740-30-2 | Etilevodopa HCl (TV-1203; Levodopa ethyl ester;L-Dopa ethyl ester; O-Ethyl-DOPA), the hydrochloride salt ofEtilevodopa, is a dopaminergic agent used for the treatment for Parkinsons disease. |
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V14604 | Metoclopramide | 364-62-5 | Metoclopramide HCl is a potent and selective dopamine D2 receptor antagonist. |
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V14823 | ONC206 | 1638178-87-6 | ONC206 (ONC-206; ONC 206), an analogue of ONC201 (TRAIL inducer) and benzyl-flurobenzyl imipridone, is a novel, potent and selective antagonist of the D2-like dopamine receptors (DRD2/3/4) with a broad-spectrum of anticancer activity. |
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V5703 | Sultopride Hydrochloride | 23694-17-9 | Sultopride HCl (LIN-1418 HCl) is a selective antagonist of dopamine D2 receptors. |
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V14049 | Tiapride HCl (Tiapridal) | 51012-33-0 | Tiapride HCl (Tiapridal),a benzamide derivative and an atypical neuroleptic agent, is a drug that selectively blocks D2 and D3 dopamine receptors in the brain. |
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