HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus.In order to create the mature protein components of an infectious HIV virion, HIV protease cleaves newly synthesized polyproteins at the proper locations. When developing anti-retroviral medications to treat HIV/AIDS (acquired immune deficiency syndrome), HIV protease is a crucial drug target.
HIV-1 protease breaks down the polyproteins Gag and Gag-Pro-Pol to allow viral maturation. More than 12 different substrates are recognized and broken down, which causes viral maturation. Similar to HIV-1, HIV-2 protease is a homodimeric aspartyl enzyme that plays a crucial part in the HIV life cycle by processing the precursor polyproteins Gag and Gag-Pro-Pol, which results in viral maturation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V53394 | 20(21)-Dehydrolucidenic acid A | 852936-69-7 | 20(21)-Dehydrolucidenic acid A is a triterpene extracted from the fruiting body of the fungus Ganoderma lucidum. |
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V0733 | Amprenavir | 161814-49-9 | Amprenavir (formerly VX-478; trade name Agenerase andProzei), an FDA approved drug for treating HIV infections, is a potent PXR-selective agonist, and an HIV protease inhibitor with the IC50of 0.6 nM on HIV-1protease, italso weakly inhibits HIV-2 protease with IC50value of 19 nM. |
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V0731 | Atazanavir Sulfate (Latazanavir, Zrivada, Reyataz, BMS232632) | 229975-97-7 | Atazanavir Sulfate (also known as Latazanavir, Zrivada, Reyataz, BMS-232632), the sulfate salt form of atazanavir, is a HIV protease inhibitor (PI) for HIV/AIDs treatment with Ki of 2.66 nM in a cell-free assay. |
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V3298 | Darunavir | 206361-99-1 | Darunavir (also known as TMC114; DRV, Trade name: Prezistaamong others) is a nonpeptidic HIV protease inhibitor andan antiretroviral medication used to treat and prevent HIV/AIDS. |
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V0732 | Darunavir Ethanolate (DRV, Prezista) | 635728-49-3 | Darunavir Ethanolate (DRV, TMC-114; UIC-94017; Trade name: Prezista), the ethanolate salt of darunavir, is a nonpeptidic HIV protease inhibitor/PI used in combination with other HIV medications to control HIV infection. |
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V56034 | Ganomycin I | 1191255-15-8 | Ganomycin I is a dual (bifunctional) inhibitor of α-glucosidase and HMG-CoA reductase. |
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V0734 | Limonin | 1180-71-8 | Limonin (also known as NSC-36508; Obaculactone; limonoate D-ring-lactone and limonoic acid di-delta-lactone), a naturally occurring limonoid, is a hexacyclic triterpenoid isolated in citrus fruits and other plants, which has antivirus and antitumor ability. |
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V0730 | Lopinavir (ABT-378; Kaletra; Aluvia) | 192725-17-0 | Lopinavir (formerly known as ABT-378; trade names Kaletra; Aluvia), an FDA approved antiretroviral drug in 2000 for HIV treatment, is a highly potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay. |
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V5184 | Nelfinavir mesylate (AG 1343) | 159989-65-8 | Nelfinavir (also known as AG-1341), themesylate salt of nelfinavir, is a novel, potent and orally bioavailable HIV-1 protease inhibitor antiviral effects. |
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V1922 | Pepstatin A | 26305-03-3 | Pepstatin A (NSC-272671; NSC272671), a pentapeptide, is a potent and selective aspartic protease inhibitor which also inhibits HIV replication. |
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V0729 | Ritonavir (ABT-538; Norvir) | 155213-67-5 | Ritonavir (previously known as ABT-538; A-84538; RTV; ABT538, trade name: Norvir) is a L-valine derivative and potent inhibitor of HIV-1 protease used to treat HIV infection and AIDS. It is widely used as a booster for other protease inhibitors/PIs such as lopinavir, and makes them work better. |
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