Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V9162 | Glabridin | 59870-68-7 | Glabridin is an isoflavane extracted from Glycyrrhiza uralensis and can bind and activate PPARγ with EC50 of 6115 nM. |
|
V5333 | Acamprosate calcium (Campral EC) | 77337-73-6 | Acamprosate calcium (also known as Campral EC),a medication used in the treatment of alcohol dependence, is a GABA receptor agonist and modulator of glutamatergic systems; it reduces alcohol consumption in animal models of alcohol addiction. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
