The different subtypes of the melanocortin (MC) receptors, which are a subfamily of G-protein-coupled receptors (GPCRs), play a variety of physiological roles, including pigmentation, steroid secretion, energy homeostasis, and food intake. Five G-protein-coupled receptors (MC1R-MC5R) make up the melanocortin receptor (MCR) family. The MC1R regulates pigmentation, the MC2R is an essential part of the hypothalamic-pituitary-adrenal axis, the MC3R, MC4R, and MC5R are involved in exocrine function, and they all play a significant role in energy homeostasis.
A number of neuropeptides known as melanocortins, such as adrenocorticotropic hormone (ACTH) and,, and -melanocyte-stimulating hormones (MSHs), activate MCRs. Pro-opiomelanocortin, a common polypeptide precursor that is primarily expressed in the hypothalamus and pituitary, is processed post-translationally to produce melanocortins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70578 | (-)-Isodocarpin (Isodocarpin) | 10391-08-9 | (-)-Isodocarpin (Isodocarpin) is a diterpenoid and a potent melanogenesis inhibitor (antagonist) with IC50 of 0.19 μM in B16 4A5 cells. |
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V86664 | (2R,2R)-PF-07258669 | 2755890-68-5 | (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. |
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V70582 | (D-Phe7)-α-MSH | 92937-43-4 | (D-Phe7)-α-MSH is an α-MSH analog. |
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V70575 | (p-Iodo-Phe7)-ACTH (4-10) | 159600-82-5 | (p-Iodo-Phe7)-ACTH (4-10) is an analogue of adrenocortical hormone (ACTH) produced and secreted by the anterior pituitary gland. |
![[D-Trp8]-γ-MSH](http://www.invivochem.com/upload/1124/V70567.png)
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V70567 | [D-Trp8]-γ-MSH | 321351-81-9 | [D-Trp8]-γ-MSH is a potent and specific melanocortin 3 (MC3) receptor agonist, inhibiting hMC3, hMC4 and hMC5 with IC50s of 6.7 nM and 600 respectively in CHO cells. |
![[D-Trp8]-γ-MSH TFA](http://www.invivochem.com/upload/1124/V77594.png)
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V77594 | [D-Trp8]-γ-MSH TFA | [D-Trp8]-γ-MSH TFA is a potent and specific melanocortin 3 (MC3) receptor agonist, inhibiting hMC3, hMC4 and hMC5 with IC50s of 6.7 nM, respectively, in CHO cells. | |
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V77292 | ACTH (1-17) (TFA) (α1-17-ACTH TFA) | ACTH (1-17) TFA is an adrenocorticotropic hormone analogue and a potent human melanocortin 1 (MC1) receptor agonist/activator with a Ki of 0.21 nM. | |
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V77294 | ACTH (11-24) (acetate) (Adrenocorticotropic Hormone (11-24) (acetate)) | ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. | |
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V70580 | ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) | 1036763-00-4 | ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). |
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V70579 | ACTH (7-38) (human) | 68563-24-6 | ACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39). |
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V77289 | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) (1-39-Corticotropin (human)(TFA)) | Adrenocorticotropic Hormone (ACTH) (1-39), human (TFA) is a melanocortin receptor agonist. | |
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V77288 | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA (ACTH (1-39) (mouse, rat) TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. | |
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V70573 | Alsactide | 34765-96-3 | Alsactide, a heptapeptide analog, is an adrenocorticotropic hormone (ACTH) agonist. |
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V65754 | Beta-Melanocyte Stimulating Hormone (MSH), human TFA (Beta-MSH (1-22) (human) TFA) | β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-peptide peptide that is an endogenous melanocortin-4 receptor (melanocortin-4 receptor; MC4-R) agonist. | |
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V70571 | Bivamelagon (MC-4R Agonist 2) | 2641595-54-0 | MC-4R Agonist 2 (Example 1) is a MC4R agonist useful in the research/study of obesity, diabetes, inflammation, and erectile dysfunction. |
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V70576 | Bivamelagon hydrochloride (MC-4R Agonist 2 hydrochloride) | 2641595-55-1 | MC-4R Agonist 2 HCl (Example 1) is a MC4R agonist that may be utilized in the study of obesity, diabetes, inflammation and erectile dysfunction. |
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V78683 | CCZ01048 | CCZ01048 is an α-MSH analog with high binding affinity to the melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. | |
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V78684 | CCZ01048 TFA | CCZ01048 TFA is an α-MSH analogue with high binding affinity to the melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. | |
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V70585 | Chlorophorin | 537-41-7 | Chlorophorin is an inhibitor (blocker/antagonist) of the Melanocortin Receptor. |
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V86663 | CRN04894 | 2392970-97-5 | CRN04894 (compound 17h) is an orally active MC2R antagonist that exhibits in vivo efficacy in a rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion. |
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