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Melanocortin Receptor

Melanocortin Receptor

The different subtypes of the melanocortin (MC) receptors, which are a subfamily of G-protein-coupled receptors (GPCRs), play a variety of physiological roles, including pigmentation, steroid secretion, energy homeostasis, and food intake. Five G-protein-coupled receptors (MC1R-MC5R) make up the melanocortin receptor (MCR) family. The MC1R regulates pigmentation, the MC2R is an essential part of the hypothalamic-pituitary-adrenal axis, the MC3R, MC4R, and MC5R are involved in exocrine function, and they all play a significant role in energy homeostasis.

A number of neuropeptides known as melanocortins, such as adrenocorticotropic hormone (ACTH) and,, and -melanocyte-stimulating hormones (MSHs), activate MCRs. Pro-opiomelanocortin, a common polypeptide precursor that is primarily expressed in the hypothalamus and pituitary, is processed post-translationally to produce melanocortins.

Melanocortin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(-)-Isodocarpin (Isodocarpin) V70578 (-)-Isodocarpin (Isodocarpin) 10391-08-9 (-)-Isodocarpin (Isodocarpin) is a diterpenoid and a potent melanogenesis inhibitor (antagonist) with IC50 of 0.19 μM in B16 4A5 cells.
(2R,2R)-PF-07258669 V86664 (2R,2R)-PF-07258669 2755890-68-5 (2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist.
(D-Phe7)-α-MSH V70582 (D-Phe7)-α-MSH 92937-43-4 (D-Phe7)-α-MSH is an α-MSH analog.
(p-Iodo-Phe7)-ACTH (4-10) V70575 (p-Iodo-Phe7)-ACTH (4-10) 159600-82-5 (p-Iodo-Phe7)-ACTH (4-10) is an analogue of adrenocortical hormone (ACTH) produced and secreted by the anterior pituitary gland.
(R)-Lirinidine V121940 (R)-Lirinidine 37082-15-8 (R)-Lirinidine is an apomorphine alkaloid found in the buds and leaves of lotus (Nelumbo nucifera).
[D-Trp8]-γ-MSH V70567 [D-Trp8]-γ-MSH 321351-81-9 [D-Trp8]-γ-MSH is a potent and specific melanocortin 3 (MC3) receptor agonist, inhibiting hMC3, hMC4 and hMC5 with IC50s of 6.7 nM and 600 respectively in CHO cells.
[D-Trp8]-γ-MSH TFA V77594 [D-Trp8]-γ-MSH TFA [D-Trp8]-γ-MSH TFA is a potent and specific melanocortin 3 (MC3) receptor agonist, inhibiting hMC3, hMC4 and hMC5 with IC50s of 6.7 nM, respectively, in CHO cells.
Ac-Arg-DL-Cys(1)-D-Ala-DL-His-D-Phe-Arg-Trp-DL-Cys(1)-NH2.CH3CO2H V102437 Setmelanotide acetate 2759937-80-7 Setmelanotide (acetate) is a melanocortin 4 receptor (MC4R) agonist that acts on human and rat MC4R with EC50 values of 0.27 nM and 0.28 nM, respectively.
Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 V118358 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 596135-92-1 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 (compound 5) is a selective hMC5R antagonist ligand with an IC50 of 10 nM.
ACTH (1-17) (TFA) (α1-17-ACTH TFA) V77292 ACTH (1-17) (TFA) (α1-17-ACTH TFA) ACTH (1-17) TFA is an adrenocorticotropic hormone analogue and a potent human melanocortin 1 (MC1) receptor agonist/activator with a Ki of 0.21 nM.
ACTH (1-17) TFA V128255 ACTH (1-17) TFA ACTH (1-17) TFA is an adrenocorticotropic hormone analog and a potent human melanocortin 1 (MC1) receptor agonist with a Ki value of 0.21 nM.
ACTH (11-24) (acetate) (Adrenocorticotropic Hormone (11-24) (acetate)) V77294 ACTH (11-24) (acetate) (Adrenocorticotropic Hormone (11-24) (acetate)) ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist.
ACTH (11-24) acetate V128253 ACTH (11-24) acetate ACTH (11-24) acetate is an adrenocorticotropic hormone (ACTH) receptor antagonist.
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) V70580 ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) 1036763-00-4 ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH).
ACTH (7-38) (human) V70579 ACTH (7-38) (human) 68563-24-6 ACTH (7-38) (human) is the 7-38 fragment of human ACTH (1-39).
Adrenocorticotropic hormone (1-39), rat TFA V128340 Adrenocorticotropic hormone (1-39), rat TFA Adrenocorticotropic hormone (1-39), rat TFA, is a potent melanocorticoid 2 (MC2) receptor agonist.
Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) (1-39-Corticotropin (human)(TFA)) V77289 Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) (1-39-Corticotropin (human)(TFA)) Adrenocorticotropic Hormone (ACTH) (1-39), human (TFA) is a melanocortin receptor agonist.
Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA (ACTH (1-39) (mouse, rat) TFA) V77288 Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA (ACTH (1-39) (mouse, rat) TFA) Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.
Albocycline K3 V128477 Albocycline K3 178114-31-3 Albocycline K3 is a microbial-derived inhibitor of melanin production.
ALD1613 V128486 ALD1613 ALD1613 is a potent anti-adrenocorticotropic hormone (ACTH) neutralizing monoclonal antibody.
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