Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a special ribonucleoprotein (RNP) with a specialized telomerase reverse transcriptase (TERT), telomerase RNA (TER), and other components necessary for TERT's activity (catalytic core), as well as species-specific TER-binding proteins crucial for biogenesis and assembly (core RNP). Other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere.
Telomerase activity is a desirable therapeutic target because it maintains chromosome end structures (telomeres) and cancer cell immortality in the majority of human malignancies. In fact, a telomerase inhibitor is anticipated to have few side effects while still having therapeutic benefits in the majority of cancers. Because they have long telomeres and express telomerase in healthy tissues, adult stem cells should be less affected by telomerase inhibition than cancer cells, which divide quickly and typically have short telomeres.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V125261 | 3′-Azido-2′,3′-dideoxy-GTP | 94059-38-8 | 3′-Azido-2′,3′-dideoxy-GTP is a selective telomerase inhibitor with a Ki value of 1.5 μM. |
|
V75876 | 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) | 101515-08-6 | 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) is a nucleotide analog and a telomerase inhibitor (IC50= 11μM). |
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V1387 | BIBR 1532 | 321674-73-1 | BIBR 1532 (BIBR-1532;BIBR1532)is a potent, highly selective, nonnucleosidic and non-competitive inhibitor of telomerase with potential anticancer activity. |
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V133695 | Diazaphilonic acid | 230287-51-1 | Diophenanthrene acid was found in Flavobacterium PF1195 strain. |
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V77035 | Epitalon TFA (Epithalon TFA; Epithalamin TFA) | Epitalon TFA is an anti-aging agent and telomerase activator. | |
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V116100 | FJ-5002 | 247129-77-7 | FJ-5002 is a telomerase inhibitor with an IC50 value of 2 μM. |
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V120359 | Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate sodium | Guanine-2'-deoxy-β-L-furanoribosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and an inhibitor of telomerase, with a Ki value of 15 μM for human enzymes. | |
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V137887 | Imetelstat | 868169-64-6 | Imetelstat is a 13-mer oligonucleotide that is a competitive telomerase inhibitor. |
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V55741 | L2H2-6OTD | 1016263-75-4 | L2H2-6OTD is an analog of a telomere inhibitor that has one to four G-quadruplex binding loops. |
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V138562 | L2H2-6OTD diformic | L2H2-6OTD diformic is a telomere inhibitor analog. | |
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V88787 | L2H2-6OTD formic | L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomerase inhibitor analog. | |
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V85370 | L2H2-6OTD intermediate-2 | 890403-75-5 | |
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V141708 | NU-PRO-1 | NU-PRO-1 is a covalent telomerase reverse transcriptase (TERT) PROTAC degrader. | |
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V145745 | TelN Protelomerase | 2747966-35-2 | TelN Protelomerase is a prokaryotic telomerase of bacteriophage N15. |
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V52967 | Telomerase-IN-2 | 1610878-54-0 | Telomerase-IN-2 is a novel inhibitor of telomerase that inhibits the activity of dyskeratin by reducing its expression, with an IC50 value of 0.89 µM. |
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V53144 | Telomerase-IN-3 | 150096-77-8 | Telomerase-IN-3 is an inhibitor of telomerase that directly targets hTERT promoter activity. |
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V85100 | Telomerase-IN-6 | ||
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V99881 | Telomerase-IN-7 | 444320-44-9 | Telomerase-IN-7 (Compound 9) is a telomerase inhibitor with IC50 of 0.03 μM. |
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V118595 | Telomerase-IN-8 | 1884341-01-8 | Telomerase-IN-8 is an orally effective telomerase inhibitor with an IC50 value of 0.98 μM. |
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V112511 | Telomerase-IN-9 | Telomerase-IN-9 is a highly effective and selective telomerase inhibitor. |
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