Telomerase

Telomerase

Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a special ribonucleoprotein (RNP) with a specialized telomerase reverse transcriptase (TERT), telomerase RNA (TER), and other components necessary for TERT's activity (catalytic core), as well as species-specific TER-binding proteins crucial for biogenesis and assembly (core RNP). Other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere.

Telomerase activity is a desirable therapeutic target because it maintains chromosome end structures (telomeres) and cancer cell immortality in the majority of human malignancies. In fact, a telomerase inhibitor is anticipated to have few side effects while still having therapeutic benefits in the majority of cancers. Because they have long telomeres and express telomerase in healthy tissues, adult stem cells should be less affected by telomerase inhibition than cancer cells, which divide quickly and typically have short telomeres.

Telomerase related products

Structure Cat No. Product Name CAS No. Product Description
V75876 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) 101515-08-6 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) is a nucleotide analog and a telomerase inhibitor (IC50= 11μM).
V1387 BIBR 1532 321674-73-1 BIBR 1532 (BIBR-1532;BIBR1532)is a potent, highly selective, nonnucleosidic and non-competitive inhibitor of telomerase with potential anticancer activity.
V1388 Costunolide (NSC 106404) 553-21-9 Costunolide [also known as (+)-Costunolide, Costus lactone, CCRIS-6754 and NSC-106404] isa naturally occurring sesquiterpene compound with a wide spectrum of biological activities such as anti-inflammatory, anticancer, antidiabetic, antiviral, antimicrobial, antiulcer,antifungal, antioxidant, and anthelmintic properties.
V77035 Epitalon TFA (Epithalon TFA; Epithalamin TFA) Epitalon TFA is an anti-aging agent and telomerase activator.
V20640 Epithalon 307297-39-8 Epitalon is an anti-aging agent and telomerase activator.
V55741 L2H2-6OTD 1016263-75-4 L2H2-6OTD is an analog of a telomere inhibitor that has one to four G-quadruplex binding loops.
V85370 L2H2-6OTD intermediate-2 890403-75-5
V52967 Telomerase-IN-2 1610878-54-0 Telomerase-IN-2 is a novel inhibitor of telomerase that inhibits the activity of dyskeratin by reducing its expression, with an IC50 value of 0.89 µM.
V53144 Telomerase-IN-3 150096-77-8 Telomerase-IN-3 is an inhibitor of telomerase that directly targets hTERT promoter activity.
V85100 Telomerase-IN-6
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