Telomerase is a DNA polymerase that extends the 3' ends of chromosomes by processively synthesizing multiple telomeric repeats. It is a special ribonucleoprotein (RNP) with a specialized telomerase reverse transcriptase (TERT), telomerase RNA (TER), and other components necessary for TERT's activity (catalytic core), as well as species-specific TER-binding proteins crucial for biogenesis and assembly (core RNP). Other proteins bind telomerase transiently or constitutively to allow association of telomerase and other proteins with telomere.
Telomerase activity is a desirable therapeutic target because it maintains chromosome end structures (telomeres) and cancer cell immortality in the majority of human malignancies. In fact, a telomerase inhibitor is anticipated to have few side effects while still having therapeutic benefits in the majority of cancers. Because they have long telomeres and express telomerase in healthy tissues, adult stem cells should be less affected by telomerase inhibition than cancer cells, which divide quickly and typically have short telomeres.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75876 | 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) | 101515-08-6 | 7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2′-dGTP) is a nucleotide analog and a telomerase inhibitor (IC50= 11μM). |
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V1387 | BIBR 1532 | 321674-73-1 | BIBR 1532 (BIBR-1532;BIBR1532)is a potent, highly selective, nonnucleosidic and non-competitive inhibitor of telomerase with potential anticancer activity. |
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V77035 | Epitalon TFA (Epithalon TFA; Epithalamin TFA) | Epitalon TFA is an anti-aging agent and telomerase activator. | |
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V55741 | L2H2-6OTD | 1016263-75-4 | L2H2-6OTD is an analog of a telomere inhibitor that has one to four G-quadruplex binding loops. |
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V88787 | L2H2-6OTD formic | L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomerase inhibitor analog. | |
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V85370 | L2H2-6OTD intermediate-2 | 890403-75-5 | |
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V52967 | Telomerase-IN-2 | 1610878-54-0 | Telomerase-IN-2 is a novel inhibitor of telomerase that inhibits the activity of dyskeratin by reducing its expression, with an IC50 value of 0.89 µM. |
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V53144 | Telomerase-IN-3 | 150096-77-8 | Telomerase-IN-3 is an inhibitor of telomerase that directly targets hTERT promoter activity. |
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V85100 | Telomerase-IN-6 | ||
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V99881 | Telomerase-IN-7 | 444320-44-9 | Telomerase-IN-7 (Compound 9) is a telomerase inhibitor with IC50 of 0.03 μM. |
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V20640 | Epithalon | 307297-39-8 | Epitalon is an anti-aging agent and telomerase activator. |
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V1388 | Costunolide (NSC 106404) | 553-21-9 | Costunolide [also known as (+)-Costunolide, Costus lactone, CCRIS-6754 and NSC-106404] isa naturally occurring sesquiterpene compound with a wide spectrum of biological activities such as anti-inflammatory, anticancer, antidiabetic, antiviral, antimicrobial, antiulcer,antifungal, antioxidant, and anthelmintic properties. |
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