MK2

MK2

MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene.It was discovered that MAPKAP kinase-2 (MK2) phosphorylates glycogen synthase at serine-7 and the serine in a peptide (GS peptide-1) designed to mimic the N-terminus of glycogen synthase.

A novel protein kinase called MAPKAP kinase-2 is triggered by mitogen-activated protein kinase. This MAPKAP kinase-2, also known as MAP kinase activated protein kinase-2, differs from S6 kinase-II (MAPKAP kinase-1) by how it reacts to inhibitors, the fact that it doesn't phosphorylate S6 peptides, and its amino acid sequence.

MK2 related products

Structure Cat No. Product Name CAS No. Product Description
V2340 MK2 Inhibitor III 724711-21-1 MK2 Inhibitor III is a potent cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) .
V4323 MK2-IN-1 1314118-92-7 MK2-IN-1 is a novel, potent,non-ATP competitive and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM).
V4322 MK2-IN-1 HCL 1314118-94-9 MK2-IN-1 HCl is a novel, potent, non-ATP competitive and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM).
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