The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29489 | (-)-Praeruptorin A | 73069-25-7 | Praeruptorin A [(9R,10S) isomer] is a naturally occuring di-esterified coumarin derivative extracted from thedried roots of Peucedanum praeruptorumDunn, which is atraditional Chinese medicine used for the treatment of cough with thick sputum and dyspnea. |
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V4180 | (R)-(+)-Bay-K-8644 | 98791-67-4 | R)-(+)-Bay-K-8644, the R-isomer ofBay-K-8644, is a novel and potent acalcium channelinhibitor/blocker that inhibits Ba2+currents (IBa) (IC50=975 nM). |
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V4179 | (S)-(-)-Bay-K-8644 | 98625-26-4 | S)-(-)-Bay-K-8644, the S-enantiomer ofBay-K-8644,is a novel and potent Ca2+ channel activator that activates Ba2+currents (IBa) with an EC50of 32 nM. |
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V2931 | ABT-639 | 1235560-28-7 | ABT-639 is a new potent, peripherally acting, selective T-type Ca2+channel blocker that blocks recombinant human T-type (Cav3.2) Ca2+channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM). |
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V1687 | AMG-517 | 659730-32-2 | AMG 517 (AMG-517; AMG517) is a novel, potent and selective TRPV1 (vanilloid receptor-1) antagonist with potential anti-inflammatory activity. |
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V1708 | Betamethasone (NSC-39470; SCH-4831) | 378-44-9 | Betamethasone (also called NSC-39470; SCH-4831;NSC39470; SCH4831)is a glucocorticoid steroid and an approved medication with moderateanti-inflammatory and immunosuppressive activities. |
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V32590 | Cav 2.2 blocker 1 | 1567335-29-8 | Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM. |
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V1693 | CFTRinh-172 | 307510-92-5 | CFTRinh-172 (also known as CFTR Inhibitor172;CFTR-Inh 172; CFTR inhibitor 172)is a potent, voltage-independent, and selective inhibitor of CFTR (Cystic fibrosis transmembrane conductance regulator) with potential anti-fibrotic and anti-diarrhea effects. |
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V29906 | DHBP dibromide (Diheptylviologen dibromide) | 6159-05-3 | DHBP dibromide(Diheptylviologen dibromide) is a potent inhibitor for calcium release and a muscle relaxant. |
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V3538 | GSK-7975A | 1253186-56-9 | GSK-7975A is a novel, potent and orally bioavailable inhibitor of CRAC (calcium release-activated calcium modulator). |
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V32977 | GV-58 | 1402821-41-3 | GV-58 is a pupin analog that acts as a novel, potent and selective agonist of N- and P/Q-type Ca2+ channels with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel. |
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V2429 | IGS-1.76 | 313480-47-6 | IGS-1.76 potently inhibits the human NCS-1/Ric8a complex. |
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V1694 | IOWH032 | 1191252-49-9 | IOWH-032 (IOWH032; IOWH 032) is a potent and synthetic CFTR (Cystic fibrosis transmembrane conductance regulator) inhibitor with antifibrotic activity. |
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V4008 | ML218 | 1346233-68-8 | ML218 (CID-45115620; ML-218; CID45115620) is a novel, potent and selective T-Type Ca(2+) (Ca(v)3.1, Ca(v)3.2, Ca(v)3.3) inhibitor (Ca(v)3.2, IC(50) = 150 nM in Ca(2+) flux; Ca(v)3.2 IC(50) = 310 nM and Ca(v)3.3 IC(50) = 270 nM, respectively in patch clamp electrophysiology) with good DMPK properties, it displayed acceptable in vivo rat PK and excellent brain levels. |
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V10543 | YM-58483(BTP2) | 223499-30-7 | YM-58483, formerly known as BTP 2, is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM). |
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V3671 | NNC 55-0396 | 357400-13-6 | NNC 55-0396 dihydrochloride salt, an analog of mibefradil, is a novel, potent and highly selective T-type calcium channel blocker which displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. |
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V26632 | NP118809 | 41332-24-5 | NP-118809 is a N-type calcium channel blocker. |
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V12267 | NS-638 | 150493-34-8 | NS-638 is a non-peptide small molecule with the property of blocking Ca2+-ion channels. |
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V1696 | O4I1 | 175135-47-4 | O4I1 (O4-I1; O4I-1; O4I 1) is a novel and potent inducer of Oct3/4 (POU5F1 and Oct4)with potential usefulness as a regenerative medicine. |
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V1695 | O4I2 | 165682-93-9 | O4I2 is a potent Oct3/4 inducer. |
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