Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago. One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on.The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0800 | Abiraterone | 154229-19-3 | Abiraterone (formerly also known as CB 7598; CB7598;CB-7598; trade name Zytiga) is a novel,higly potent, irreversible and selectiveCYP17 inhibitor with potential antineoplastic activity. |
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V0801 | Abiraterone Acetate (Zytiga; formerly CB-7598; CB7598; CB 7598) | 154229-18-2 | Abiraterone Acetate (brand name Zytiga; formerly CB-7598; CB7598;CB 7598),the 3-acetylated and prodrug form of Abiraterone, is an irreversible and steroidal cytochrome CYP17 inhibitor with potential antitumor activity. |
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V0821 | Alizarin | 72-48-0 | Alizarin is a naturally occuring and anthraquinone-based dye extracted from the roots of madder plant. |
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V0808 | Apigenin | 520-36-5 | Apigenin (NSC-83244, LY-080400;4,5,7-Trihydroxyflavone; Apigenol; C. |
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V0803 | Avasimibe | 166518-60-1 | Avasimibe (CI-1011; PD 148515;CI1011; CI 1011; PD148515; PD-148515) is a novel, potent and orally bioavailable inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) with the potential for the treatment of atherosclerosis and hyperlipidaemia. |
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V0807 | Baicalein | 491-67-8 | Baicalein (5,6,7-Trihydroxyflavone; Noroxylin;BaiKalein), a naturally occuring flavone, is a potent inhibitor of CYP2C9, prolyl endopeptidase, and xanthine oxidasewith important biological activity (e. |
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V0813 | Benzbromarone | 3562-84-3 | Benzbromarone (L2214; L 2214; MJ-10061;MJ10061;L-2214; L2214-Labaz; Narcaricin; Normurat), an approved anti-gout drug (uricosuric drug) for the last 30 years, is a potent CYP2C9 inhibitor with Ki value of 19.3 nM. |
|
V13078 | Cedrol | 77-53-2 | Cedrol is a bioactive sesquiterpene and a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. |
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V0814 | Clarithromycin | 81103-11-9 | Clarithromycin (A56268; Abbott 56268; A 56268; Abbott-56268; A-56268; trade name Biaxin) is an approved macrolide antibiotic medication acting as a CYP3A4 inhibitor. |
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V0815 | Cobicistat (GS9350) | 1004316-88-4 | Cobicistat (trade name Tybost;Genvoya;GS-9350; GS 9350) is a novel, potent and selective inhibitor of CYP3A (cytochrome P450 3A) with IC50 of 30-285 nM. |
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V26981 | Dazoxiben HCl | 74226-22-5 | Dazoxiben is a potent orally bioactive thromboxane (TX) synthase inhibitor. |
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V0810 | Diosmetin | 520-34-3 | Diosmetin (also known as DIO; HSDB 8101; HSDB 8101; Luteolin 4-methyl ether)is a naturally occuring flavonoid found in spearmint, oregano, and many other plants with various biological activity (e. |
|
V2226 | DMU-2105(CYP1B1 inhibitor 7k) | 1031063-36-1 | DMU-2105(CYP1B1 inhibitor 7k), is a novel,potent and selective CYP1B1 inhibitor with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. |
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V2872 | Ezutromid (BMN-195, SMTC-1100) | 945531-77-1 | Ezutromid (also known as BMN-195 and SMTC-1100) is a first-in-class, orally bioavailable,small molecule modulator of the utrophins translation with EC50 of 0.4 uM. |
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V0806 | Fluconazole (UK49858) | 86386-73-4 | Fluconazole (Diflucan,UK-49858;UK 49858; Triflucan, Elazor, Biozolene) is a novel, potent, and orally bioavailable triazole-based antifungal drug that works by inhibiting fungal lanosterol 14 alpha-demethylase-dependent biosynthesis of ergosterol, which is an essential component of fungal cell membrane. |
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V0811 | Galeterone | 851983-85-2 | Galeterone (formerly known as NX 41765;TOK001;VN/124-1; NX-41765; VN-1241;TOK-001) is a novel, potent and selective, orally bioavailable CYP17 lyase inhibitor and androgen receptor (AR) antagonist with potential anticancer activity. |
|
V0805 | Itraconazole | 84625-61-6 | Itraconazole (Orungal, Oriconazole, Sporanox,R51211;R-51211), a marketedtriazole-based antifungal drug since 1984, is a potent inhibitor of CYP3A4 that has been widely used for the treatment of fungal infections. |
|
V0804 | Ketoconazole | 65277-42-1 | Ketoconazole (Ketoconazol; Fungoral,Nizoral, Kuric, Xolegel, Ketoderm; Extina; R-41400; R 41400),a CYP3A4 and 24A1 inhibitor and antifungal agent, is a potent and synthetic imidazole-based antifungal drug used primarily to treat fungal infections. |
|
V25374 | Methoxsalen (Xanthotoxin; 9-MOP) | 298-81-7 | Methoxsalen(8-Methoxypsoralen) is a naturally occurring chemical substance extracted from the seeds of the plant Ammi majus with photoactivating properties. |
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V0812 | Naringenin | 480-41-1 | Naringenin(S-Dihydrogenistein; Salipurol;NSC 11855; NSC-11855; NSC11855) is a naturally occuring flavanone extracted from plant food (e. |
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