The mTOR gene in humans produces the protein known as mTOR (mammalian target of rapamycin). A serine/threonine protein kinase called mTOR controls transcription, protein synthesis, cell motility, growth, and proliferation in living things. The phosphatidylinositol 3-kinase-related kinase protein family includes mTOR. Growth factors and amino acids are just two examples of the input from upstream pathways that mTOR integrates.Additionally, mTOR detects cellular energy, oxygen, and nutrient levels. In human diseases like diabetes, obesity, depression, and some cancers, the mTOR pathway is dysregulated. By collaborating with its intracellular receptor FKBP12, rapamycin inhibits mTOR. The mTOR FKBP12-Rapamycin Binding (FRB) domain is directly contacted by the FKBP12-rapamycin complex, which inhibits mTOR activity.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2177 | (+)-Usniacin | 7562-61-0 | Usniacin, [(+)-Usnic acid] is a natually occuring compound isolated from lichens, which binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. |
|
V102460 | (2S,6S)-Hydroxynorketamine hydrochloride | 1430202-70-2 | (2S,6S)-Hydroxynorketamine hydrochloride is a neuroleptic active molecule with potential antidepressant and analgesic effects. |
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V70240 | (32-Carbonyl)-RMC-5552 | 2382768-55-8 | (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. |
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V70255 | 10-Hydroxy-2-decenoic acid (10-HDA) | 765-01-5 | 10-Hydroxy-2-decenoic acid (10-HDA) is the main lipid component of royal jelly produced by bees. |
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V104896 | 2DII | 2DII is a potent and selective mTORC2 inhibitor. | |
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V9496 | 3BDO | 890405-51-3 | 3BDO is a butyrolactone analog which acts as amTOR activator, ittargets FKBP1A and activate the mTOR signaling pathway. |
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V97457 | 4-FPBUA | 2089636-93-9 | 4-FPBUA is a semisynthetic analog of lichenic acid that enhances cell-based blood-brain barrier (BBB) function and increases the trafficking of β-amyloid (Aβ) in monolayer cells. |
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V0177 | AZD8055 | 1009298-09-2 | AZD8055 is a novel, potent selective, and orally bioavailableATP-competitive mTOR (mammalian target of rapamycin) inhibitor with potential anticancer activity. |
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V70245 | CC214-1 | 1021920-32-0 | CC214-1 is a potentially effective mTOR inhibitor that can induce autophagy with IC50 of 0.002 μM. |
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V110325 | CIDD 0067106 | 2151865-39-1 | CIDD-0067106 is a selective mTORC1 pathway inhibitor that targets androgen receptor-positive (AR+) triple-negative breast cancer (TNBC). |
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V96744 | DA-143 | DA-143 is a selective DNA-PKcs inhibitor (IC50: 2.5 nM), with IC50 of 280 nM, 106 nM and 6,594 nM for mTOR, PI3KΔ and ATM, respectively. | |
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V19634 | Desmethyl-VS-5584 | 1246535-95-4 | Desmethyl-VS-5584 is a dimethyl analog of VS-5584, a potent and specific mTOR/PI3K dual (bifunctional) inhibitor (antagonist) with a pyridine[2,3-d]pyrimidine structure. |
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V87900 | Desmethyl-VS-5584 hydrochloride | Desmethyl-VS-5584 hydrochloride is a dimethyl analog of VS-5584, a potent and selective dual mTOR/PI3K inhibitor, with a pyridine[2,3-d]pyrimidine structure. | |
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V70247 | Dihydroevocarpine | 15266-35-0 | Dihydroevocarpine induces acute myeloid leukemia cell toxicity/cytotoxicity by inhibiting mTORC1/2 activity. |
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V86185 | DNA-PK-IN-11 | 1360628-91-6 | |
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V85069 | DNA-PK-IN-12 | 2792146-91-7 | |
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V0205 | GDC-0349 (RG7603) | 1207360-89-1 | GDC-0349(also known asRG-7603) is a novel, potent,orally bioavailable and selective ATP-competitive inhibitor of mTOR (mammalian target of rapamycin) with potential antitumor activity. |
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V86091 | GNE-555 | 1428902-71-9 | |
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V110518 | GP262 | GP262 is a PI3K/mTOR protein thio compound that targets PI3Kγ, PI3K and mTOR, with DC50 values of 42.23 nM and 45.4 nM in MDA-MB-231 cells, respectively. | |
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V111114 | ICSN3250 | 1561902-73-5 | ICSN3250 is a hallucinogenic analogue and a specific mTORC1 inhibitor. |
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