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mTOR

mTOR

The mTOR gene in humans produces the protein known as mTOR (mammalian target of rapamycin). A serine/threonine protein kinase called mTOR controls transcription, protein synthesis, cell motility, growth, and proliferation in living things. The phosphatidylinositol 3-kinase-related kinase protein family includes mTOR. Growth factors and amino acids are just two examples of the input from upstream pathways that mTOR integrates.Additionally, mTOR detects cellular energy, oxygen, and nutrient levels. In human diseases like diabetes, obesity, depression, and some cancers, the mTOR pathway is dysregulated. By collaborating with its intracellular receptor FKBP12, rapamycin inhibits mTOR. The mTOR FKBP12-Rapamycin Binding (FRB) domain is directly contacted by the FKBP12-rapamycin complex, which inhibits mTOR activity.

mTOR related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Usniacin V2177 (+)-Usniacin 7562-61-0 Usniacin, [(+)-Usnic acid] is a natually occuring compound isolated from lichens, which binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity.
(32-Carbonyl)-RMC-5552 V70240 (32-Carbonyl)-RMC-5552 2382768-55-8 (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor.
10-Hydroxy-2-decenoic acid (10-HDA) V70255 10-Hydroxy-2-decenoic acid (10-HDA) 765-01-5 10-Hydroxy-2-decenoic acid (10-HDA) is the main lipid component of royal jelly produced by bees.
3BDO V9496 3BDO 890405-51-3 3BDO is a butyrolactone analog which acts as amTOR activator, ittargets FKBP1A and activate the mTOR signaling pathway.
AZD8055 V0177 AZD8055 1009298-09-2 AZD8055 is a novel, potent selective, and orally bioavailableATP-competitive mTOR (mammalian target of rapamycin) inhibitor with potential anticancer activity.
CC214-1 V70245 CC214-1 1021920-32-0 CC214-1 is a potentially effective mTOR inhibitor that can induce autophagy with IC50 of 0.002 μM.
Desmethyl-VS-5584 V19634 Desmethyl-VS-5584 1246535-95-4 Desmethyl-VS-5584 is a dimethyl analog of VS-5584, a potent and specific mTOR/PI3K dual (bifunctional) inhibitor (antagonist) with a pyridine[2,3-d]pyrimidine structure.
Dihydroevocarpine V70247 Dihydroevocarpine 15266-35-0 Dihydroevocarpine induces acute myeloid leukemia cell toxicity/cytotoxicity by inhibiting mTORC1/2 activity.
DNA-PK-IN-11 V86185 DNA-PK-IN-11 1360628-91-6
DNA-PK-IN-12 V85069 DNA-PK-IN-12 2792146-91-7
Everolimus (RAD-001, SDZ-RAD) V0175 Everolimus (RAD-001, SDZ-RAD) 159351-69-6 Everolimus (formerly also known as RAD001, SDZ-RAD, or the40-O-(2-hydroxyethyl) derivative of sirolimus) is a potent and orally bioavailable inhibitor of mammalian target of rapamycin (mTOR) with immunosuppressive activity.
GDC-0349 (RG7603) V0205 GDC-0349 (RG7603) 1207360-89-1 GDC-0349(also known asRG-7603) is a novel, potent,orally bioavailable and selective ATP-competitive inhibitor of mTOR (mammalian target of rapamycin) with potential antitumor activity.
GNE-555 V86091 GNE-555 1428902-71-9
KU-0063794 V0179 KU-0063794 938440-64-3 KU-0063794 is a novel, potent, cell permeable and selective inhibitor of mTOR (mammalian target of rapamycin) with potential anticancer activity.
L-Leucine-1-13C V15518 L-Leucine-1-13C 74292-94-7 L-Leucine-13C is a 13C (carbon 13)-labeled L-Leucine.
L-LEUCINE-13C6 V2271 L-LEUCINE-13C6 201740-84-3 L-Leucine-13C6 is 13C (carbon 13) labeled L-Leucine.
LGB321 monohydrochloride V84608 LGB321 monohydrochloride 1469925-36-7
MHY-1685 V70237 MHY-1685 27406-31-1 MHY-1685 is a novel mTOR inhibitor that offers the opportunity to improve hCSC-based myocardial regeneration.
MHY1485 V0209 MHY1485 326914-06-1 MHY1485 is a novel, potent andcell-permeable activator of mTOR(mammalian target of rapamycin) and an inhibitor of autophagy that suppress the fusion between autophagosomes and lysosomes.
MTI-31 (LXI-15029) V70235 MTI-31 (LXI-15029) 1567915-38-1 MTI-31 (LXI-15029) is a potent, orally bioactive, and selective inhibitor of mTORC1 and mTORC2.
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