Synuclein is a protein that is found in abundance in neurons and is particularly enriched in presynaptic nerve terminals. Synaptic vesicle trafficking and ensuing neurotransmitter release are controlled by -synuclein. -synuclein has been linked to Parkinson's disease (PD) and other neurodegenerative diseases through genetic and neuropathology research. Multiple neurodegenerative diseases known as synucleinopathies are characterized by the accumulation of misfolded oligomers and larger aggregates of -synuclein, but the mechanisms by which -synuclein acts in neurodegeneration are unknown.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70176 | (Rac)-Minzasolmin ((Rac)-UCB0599; NPT200-11) | 1802518-63-3 | (Rac)-Minzasolmin ((Rac)-UCB0599) is a brain barrier-penetrating inhibitor that can suppress the accumulation of alpha-synuclein (ASYN) misfolding and aggregation. |
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V70190 | (S)-Minzasolmin ((S)-UCB0599; (S)-NPT200-11) | 1802518-91-7 | (S)-Minzasolmin is an enantiomer of Minzasolmin, an inhibitor (blocker/antagonist) of α-synuclein oligomerization. |
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V109175 | 1-Aminoindan | 34698-41-4 | 1-Aminoindene (1-indeneamine) is a metabolite of rasagiline. |
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V112669 | Alpinin A | 2151847-03-7 | Galangin A is a diarylheptane compound found in the rhizomes of galangal (Alpinia officinarum). |
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V108926 | Arg-PEG1-Tαsyn | Arg-PEG1-Tαsyn is a PROTAC degrader targeting α-synuclein, with a median lethal concentration (DC50) of 0.28 μM in U251 cells. | |
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V80156 | Brazilin-7-acetate | Brazilin-7-acetate (B-7-A) is an inhibitor (blocker/antagonist) of α-synuclein (α-Syn) aggregates. | |
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V70194 | D-685 | 2893801-00-6 | D-685, a prodrug of D-520, displays greater in vivo anti-PD/Parkinson's disease efficacy than parent D-520 in a lipidated animal model of PD/Parkinson's disease. |
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V94863 | GSD-16-24 | GSD-16-24 is a lead compound that binds directly to the C-terminal IDR of α-syn monomers and fibrils, thereby preventing fibrils from binding to the receptor. | |
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V87865 | LETC | LETC is an orally active inhibitor of α-synuclein (α-Syn) aggregation with an EC50 of 66 nM in transfected DH60.21 neuroblastoma cells. | |
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V70179 | Minzasolmin (UCB0599; (R)-NPT200-11) | 1802518-92-8 | Minzasolmin is an inhibitor (blocker/antagonist) of alpha-synuclein oligomerization. |
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V120388 | MK-7337 | 3056154-69-6 | MK-7337 is a PET ligand for α-synuclein. |
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V116748 | Movronersen | 2411937-33-0 | Movronersen is an antisense oligonucleotide that targets α-synuclein. |
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V116768 | Movronersen sodium | Movronersen sodium is an antisense oligonucleotide that targets α-synuclein. | |
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V3222 | ELN484228 | 312-63-0 | ELN484228, a phenyl-sulfonamide compound, is a cell-permeable blocker ofα-synucleinwhich is a key protein in Parkinson’s disease. |
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V112289 | NPT100-18A | NPT100-18A is an inhibitor of α-synuclein oligomerization. | |
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V87863 | NS163 | NS163 is an α-Synuclein aggregation antagonist. | |
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V114765 | PBT434 free base | 1232840-87-7 | PBT434 (ATH434) free base is a potent, orally effective, blood-brain barrier-crossing α-synuclein aggregation inhibitor. |
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V70181 | PBT434 mesylate (ATH434 mesylate) | 2387898-69-1 | PBT434 methanesulfonate is a potent, orally bioactive, α-synuclein aggregation inhibitor that crosses the BBB (blood-brain barrier). |
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V87864 | PDpep1.3 | PDpep1.3 is a peptide inhibitor whose main activity is to disrupt the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). | |
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V70192 | Peucedanocoumarin III | 130464-57-2 | Peucedanocoumarin III is an α-synuclein and huntingtin aggregate inhibitor that enhances the clearance of nuclear and cytoplasmic β23 aggregates and protects against disease-associated proteins (i. |
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