Synuclein is a protein that is found in abundance in neurons and is particularly enriched in presynaptic nerve terminals. Synaptic vesicle trafficking and ensuing neurotransmitter release are controlled by -synuclein. -synuclein has been linked to Parkinson's disease (PD) and other neurodegenerative diseases through genetic and neuropathology research. Multiple neurodegenerative diseases known as synucleinopathies are characterized by the accumulation of misfolded oligomers and larger aggregates of -synuclein, but the mechanisms by which -synuclein acts in neurodegeneration are unknown.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70176 | (Rac)-Minzasolmin ((Rac)-UCB0599; NPT200-11) | 1802518-63-3 | (Rac)-Minzasolmin ((Rac)-UCB0599) is a brain barrier-penetrating inhibitor that can suppress the accumulation of alpha-synuclein (ASYN) misfolding and aggregation. |
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V70190 | (S)-Minzasolmin ((S)-UCB0599; (S)-NPT200-11) | 1802518-91-7 | (S)-Minzasolmin is an enantiomer of Minzasolmin, an inhibitor (blocker/antagonist) of α-synuclein oligomerization. |
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V80156 | Brazilin-7-acetate | Brazilin-7-acetate (B-7-A) is an inhibitor (blocker/antagonist) of α-synuclein (α-Syn) aggregates. | |
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V70187 | Cinpanemab (BIIB054; Anti-Alpha-synuclein Reference Antibody (cinpanemab)) | 2094516-02-4 | Cinpanemab (BIIB054) is a human monoclonal antibody (mAb) that binds to α-synuclein residues 1-10. |
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V70194 | D-685 | 2893801-00-6 | D-685, a prodrug of D-520, displays greater in vivo anti-PD/Parkinson's disease efficacy than parent D-520 in a lipidated animal model of PD/Parkinson's disease. |
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V3222 | ELN484228 | 312-63-0 | ELN484228, a phenyl-sulfonamide compound, is a cell-permeable blocker ofα-synucleinwhich is a key protein in Parkinson’s disease. |
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V70179 | Minzasolmin (UCB0599; (R)-NPT200-11) | 1802518-92-8 | Minzasolmin is an inhibitor (blocker/antagonist) of alpha-synuclein oligomerization. |
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V70181 | PBT434 mesylate (ATH434 mesylate) | 2387898-69-1 | PBT434 methanesulfonate is a potent, orally bioactive, α-synuclein aggregation inhibitor that crosses the BBB (blood-brain barrier). |
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V70192 | Peucedanocoumarin III | 130464-57-2 | Peucedanocoumarin III is an α-synuclein and huntingtin aggregate inhibitor that enhances the clearance of nuclear and cytoplasmic β23 aggregates and protects against disease-associated proteins (i. |
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V70186 | Prasinezumab (PRX 002; RG 7935; RO 7046015) | 1960462-19-4 | Prasinezumab (PRX 002) is a humanized IgG1 monoclonal antibody (mAb) directed against aggregated α-synuclein. |
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V78513 | Sycosterol A | Sycosterol A is an alpha-synuclein (α-syn) sterol inhibitor. | |
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V70173 | SynuClean-D (SC-D) | 685121-45-3 | SynuClean-D (SC-D) is an inhibitor (blocker/antagonist) of alpha-synuclein aggregation that disrupts mature amyloid fibrils, prevents fibril multiplication, and eliminates dopamine in animal models of PD/Parkinson's disease Degeneration of neuronal neurons. |
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V79961 | tau protein/α-synuclein-IN-1 | tau protein/α-synuclein-IN-1 is a dual (bifunctional) inhibitor of tau protein and α-synuclein. | |
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V70180 | Utreloxastat (PTC857) | 1213269-96-5 | Utreloxastat (PTC857) is a compound utilized in the research of diseases including alpha-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemia-reperfusion-related injury. |
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V70189 | α-Synuclein (34-45) (human) | 2170181-52-7 | α-Synuclein (34-45) (human) is the 34-45 fragment of α-Synuclein. |
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V70193 | α-Synuclein (45-54) (human) | 2243206-98-4 | α-Synuclein (45-54) (human) is the 45-54 fragment of α-Synuclein. |
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V70188 | α-Synuclein (61-75) | 440645-08-9 | α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. |
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V68754 | α-Synuclein (61-75) (TFA) | α-Synuclein (61-75) TFA is the 61-75 fragment of α-Synuclein. | |
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V70195 | α-Synuclein (61-95) (human) | 154040-19-4 | α-Synuclein (61-95) (human) is the hydrophobic core region of α-Synuclein that induces neuronal cell death. |
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V70191 | α-Synuclein (67-78) (human) | 2243206-99-5 | α-Synuclein (67-78) (human) is the 67-78 fragment of α-Synuclein. |
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