The positive-strand RNA virus known as hepatitis C virus (HCV) belongs to the family Flaviviridae's genus Hepacivirus. At least six genotypes (gt) of HCV exist, and the polymerase's error-prone nature results in more than 50 subtypes. The host and viral proteases break down the long open reading frame, which encodes the HCV polyprotein, into seven nonstructural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) and three structural proteins (the capsid protein core and envelope glycoproteins E1 and E2). While NS3 to NS5B are involved in a membrane-associated RNA replicase complex (RC), NS2 and p7 are required for virus assembly but not RNA replication.NS4A acts as a cofactor for the NS3 serine protease, NS5B is the RNA-dependent RNA polymerase, and NS5A is thought to play important roles in numerous stages of the HCV life cycle. The NS3 protein is made up of a serine protease and an RNA helicase/nucleoside triphosphatase (NTPase).After being administered to HCV-infected cells, NS5A inhibitors quickly reduce the virus' ability to infect cells.

By preventing Kv2.1 function and preventing apoptosis, the HCV protein NS5A prevents the loss of intracellular potassium that would otherwise occur in hepatocytes.

Alpha interferon, Telaprevir, the NS5A inhibitor BMS-790052, and PSI-7977, as well as the combination of lucidone and alpha interferon, all work synergistically to inhibit HCV RNA replication.

HCV related products

Structure Cat No. Product Name CAS No. Product Description
V54173 (Tetrahydro-2H-pyran-4-yl)methanol 14774-37-9 (Tetrahydro-2H-pyran-4-yl)methanol is a biochemical compound that can be used as a biomaterial or organic/chemical reagent for biomedical research.
V53271 2'-C-Methyladenosine 15397-12-3 2'-C-Methyladenosine is an inhibitor (blocker/antagonist) of HCV (hepatitis C virus) replication.
V53157 2'-O-Methylcytidine 2140-72-9 2'-O-Methylcytidine is a 2'-generation nucleoside that can inhibit HCV (hepatitis C virus) replication.
V76311 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose 169516-60-3 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose is a nucleoside analogue.
V4403 ABT-072 1132936-00-5 ABT-072 is a novel and potent nonnucleosideNS5B polymeraseinhibitor and a candidate drug evaluated for treatment of hepatitis C virus (HCV).
V52456 ABT-072 potassium trihydrate 1132940-31-8 ABT-072 (potassium trihydrate) is an orally bioactive and potent non-nucleoside HCV (hepatitis C virus) NS5B polymerase inhibitor (HCV (hepatitis C virus) GT1a EC50=1 nM; HCV (hepatitis C virus) GT1b EC50=0.3 nM).
V54241 Ac-D-DGla-LI-Cha-C 208940-40-3 Ac-D-DGla-LI-Cha-C is a potent HCV (hepatitis C virus) protease inhibitor peptide.
V54240 Ac-EEVVAC-pNA 389868-12-6 Ac-EEVVAC-pNA is a chromogenic substrate for the continuous spectrophotometric determination of HCV (hepatitis C virus) NS3 protease.
V54238 AL-611 2481279-61-0 AL-611 is an HCV (hepatitis C virus) NS5B polymerase inhibitor (EC50 = 5 nM).
V54233 Antiviral agent 30 381731-49-3 antiviral compound 30 (Example 118) is an antiviral compound.
V76306 Apigenin-4'-α-L-rhamnoside 133538-77-9 Apigenin-4'-α-L-rhamnoside is a potent HBV (hepatitis B virus) inhibitor.
V5119 Artemisinin (Qinghaosu; NSC 369397) 63968-64-9 Artemisinin (also known as qinghaosu in Chinese; NSC-369397), discovered by Tu Youyou (2015 Nobel Prize winner in Medicine) team, is a naturally occurring anti-malarial drug isolated from the aerial parts ofArtemisia annuaL.
V54227 ASP5286 935735-70-9 ASP5286 is a novel non-immune cyclophilin inhibitor for the study of HCV (hepatitis C virus).
V3153 Asunaprevir 630420-16-5 Asunaprevir (formerly BMS-650032; BMS-650032; trade name in Japan and Russia: Sunvepra) is a potent and orally bioavailable small molecule inhibitor of thehepatitis C virus (HCV) NS3 (non-structural) protease that has been approved for use in Japan as part of a combination treatment for HCV infections.
V2064 Balapiravir (R1626, Ro 4588161) 690270-29-2 Balapiravir (also known as R1626 and Ro 4588161) is the tri-isobutyl ester prodrug of R1479 which is a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase.
V3517 Beclabuvir (BMS-791325) 958002-36-3 Beclabuvir (formerlyknown as BMS-791325) is a novel, potent and non-nucleoside inhibitor of the HCV NS5B RNA polymerase, with nanomolar activity against HCV genotypes 1, 3, 4, 5 and 6 in vitro.
V52352 Beclabuvir (BMS-791325) 958002-33-0 Beclabuvir is an HCV (hepatitis C virus) NS5B RNA-dependent RNA polymerase inhibitor that can also inhibit the activity of NS5B protein expressed by HCV (hepatitis C virus) genotypes 1, 2, 4, and 5, with IC50s < 28 nM.
V76303 Besifovir (LB80331) 441785-25-7 Besifovir (LB80331) is the parent active molecule of LB80380 and is further metabolized to its active form LB80317.
V54219 Cepeginterferon alfa-2b 1192706-52-7 Cepeginterferon alfa-2b is a pegylated interferon with a PEG base of 20 kDa molecular weight.
V53237 CpG ODN 10101 (ODN 10101) 1234402-77-7 CpG ODN 10101 is a synthetic oligodeoxynucleotide (ODN) that is a Toll-like receptor 9 (TLR9) agonist.
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