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Lactate Dehydrogenase

Lactate Dehydrogenase

Lactate Dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate, the end product of glycolysis, into lactate (and vice versa) with concomitant interconversion of NADH and NAD+.LDH is made up of two main subunits, LDH-A and LDH-B. These two subunits can combine to form LDH1, LDH2, LDH3, LDH4, and LDH5, one of five isoenzymes.

Due to its predominance in skeletal muscle, LDH-A is also known as the M subunit, and LDH-B is known as the H subunit due to its predominance in the heart. An essential metabolic enzyme called LDH-A has been linked to the growth, invasion, and metastasis of cancer. The main contributor to the Warburg effect is LDH-A. Multiple cancers' clinicopathologic traits and survival rates have been shown to correlate with LDH-A. LDH-A inhibition inhibits the proliferation of primary breast tumors. A vital glycolytic enzyme called LDH-B catalyzes the transformation of lactate and NAD+ into pyruvate, NADH, and H+. When it comes to autophagy in cancer cells, LDHB is crucial.

Lactate Dehydrogenase related products

Structure Cat No. Product Name CAS No. Product Description
6-O-Oleoyltrehalose V120326 6-O-Oleoyltrehalose 338733-38-3 6-O-oleoyl trehalose is a derivative of trehalose.
ACS03 V112134 ACS03 2227022-64-0 ACS03 is a thiophene-acridine hybrid compound.
Antibacterial agent 306 V110878 Antibacterial agent 306 Antimicrobial agent 306 (compound 8c) is a lactate dehydrogenase inhibitor with potent antimicrobial activity, especially effective against Gram-positive bacteria.
Anticancer agent 121 V73842 Anticancer agent 121 2924532-47-6 Anticancer agent 121 is a human lactate dehydrogenase A enzyme inhibitor (hLDHA) with good anti-cancer activity and may be utilized in antitumor research.
Anticancer agent 122 V73847 Anticancer agent 122 2924532-50-1 Anticancer agent 122 is a human lactate dehydrogenase A enzyme inhibitor (hLDHA) with good anti-cancer activity and may be utilized in antitumor research.
AXKO-0046 dihydrochloride V77222 AXKO-0046 dihydrochloride AXKO-0046 di-HCl, an indole analogue, is a selective inhibitor of LDHB.
Bisadinrone A V116109 Bisadinrone A 2871811-08-2 Bisadione A is a sesquiterpene found in turmeric (Curcuma longa).
CHK-336 V73843 CHK-336 2743436-86-2 CHK-336 (Example 1) is an orally bioavailable LDHA inhibitor (IC50＜1 nM), which can inhibit lactate production in mouse hepatocytes.
D-Lactate dehydrogenase (D-LDH) V73845 D-Lactate dehydrogenase (D-LDH) 9028-36-8 D-Lactate dehydrogenase (D-LDH) is an oxidoreductase that uses NAD+ or NADP+ as an acceptor and acts on the donor CH-OH group.
D-Lactic Dehydrogenase, Staphylococcus epidermidis V109975 D-Lactic Dehydrogenase, Staphylococcus epidermidis Staphylococcus epidermidis D-lactate dehydrogenase (EC 1.1.1.28) catalyzes the conversion of D-lactate to D-pyruvate, while simultaneously reducing NAD+ to NADH and H+.
Dual GO/LDHA-IN-1 V109200 Dual GO/LDHA-IN-1 Dual GO/LDHA-IN-1 is an orally effective dual-target glycolate oxidase (GO)/lactate dehydrogenase A (LDHA) inhibitor with Ki values of 390 nM and 40 nM, respectively.
FX11 V21444 FX11 213971-34-7 FX-11 is a novel, potent and selective lactate dehydrogenase A (LDHA) inhibitor with anticancer activity.
GNE-140 racemate V73840 GNE-140 racemate 1802977-61-2 GNE-140 racemate is a racemic mixture (racemate) of (R)-GNE-140 and (S)-GNE-140.
GSK2837808A V3951 GSK2837808A 1445879-21-9 GSK2837808A is a potent, selective, andan NADH-competitiveinhibitor of lactate dehydrogenase A (LDHA) withIC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.
L-Lactate Dehydrogenase, Porcine V110226 L-Lactate Dehydrogenase, Porcine L-lactate dehydrogenase, also known as porcine lactate dehydrogenase, is an enzyme found in almost all living cells (animals, plants, and prokaryotes).
L-Lactic Dehydrogenase, Porcine V109886 L-Lactic Dehydrogenase, Porcine Porcine L-lactate dehydrogenase (EC 1.1.1.27) is an enzyme found in almost all living cells (animals, plants, and prokaryotes).
Lactate Dehydrogenase, Porcine V109971 Lactate Dehydrogenase, Porcine Porcine lactate dehydrogenase (EC 1.1.1.27) is a natural porcine lactate dehydrogenase used to study lactate metabolism and enzymatic mechanisms.
LDH-IN-3 V104239 LDH-IN-3 LDH-IN-3 (compound E38) is an inhibitor of lactate dehydrogenase (LDH) and a potential protective agent against ischemic neurological damage in the eye and brain.
LDH-IN-5 V115944 LDH-IN-5 2768522-31-0 LDH-IN-5 is a lactate dehydrogenase (LDH) inhibitor with neuroprotective effects.
LDHA-IN-10 V116677 LDHA-IN-10 LDHA-IN-10 (compound HP19) is a lactate dehydrogenase A (LDHA) inhibitor with an IC50 value of 5.2 μM.
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