NO Synthase

NO Synthase

A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.

NO Synthase related products

Structure Cat No. Product Name CAS No. Product Description
V75149 (+)-Hannokinol 408324-76-5 (+)-Hannokinol can be extracted from the fruits of AMOMUM TSAO-KO (Zingiberaceae).
V84404 (+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) 59092-94-3
V75146 (-)-10,11-Dihydroxyfarnesol 37133-76-9 (-)-10,11-Dihydroxyfarnesol is a compound extracted from the endophytic fungus Cryptomarasmius aucubae.
V71565 (Rac)-Zevaquenabant ((Rac)-MRI-1867) 1610420-28-4 (Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a CB1R/iNOS dual-targeting inhibitor (antagonist) with a Ki of 5.7 nM for CB1R.
V77363 (Rac)-ZLc-002 (Rac)-ZLc-002 is an inhibitor (blocker/antagonist) of the interaction between nNOS and nitric oxide synthase 1 adapter protein (NOS1AP), inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergizes with Paclitaxel to reduce tumor cell viability.
V75092 (S)-ZLc002 308277-46-5 (S)-ZLc002 is the S-enantiomer of ZLc-002.
V84184 1400W (W1400) 180001-34-7
V2716 1400W 2HCl 214358-33-5 1400W (1400-W) is a slow, tight binding, potent, and highlyselective inhibitor of inducible nitric-oxide synthase (iNOS) withKivalues of 7 nM.
V83602 3,4-DAA 2117759-07-4
V75095 3-Amino-1,2,4-triazine 1120-99-6 3-Amino-1,2,4-triazine is a NO synthase inhibitor and can also inhibit the secretion of nitrite.
V75119 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is a triterpenoid with anti~inflammatory activity.
V75125 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) 23050-38-6 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) comes from Andrographis paniculata and can inhibit NO with IC50 of 39.1 μM.
V75135 6-Methoxynaringenin 94942-49-1 6-Methoxynaringenin is a naturally occurring flavonoid that can inhibit NO production with IC50 of 25.8 μM.
V75122 8A8 2766594-12-9 8A8 is a potent inhibitor of the pro-inflammatory factor NO with IC50 of 4.7 μM.
V75152 9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) 22333-58-0 9-Hydroxy-α-lapachone (α-DiHydrocaryopterone) is a natural phenol that potently inhibits LPS-induced NO production in RAW 264.7 cells with IC50 of 4.64 µM.
V75127 Alismol 87827-55-2 Alismol is a natural sesquiterpene.
V75110 Aloenin aglycone 59163-53-0 Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be extracted from aloe exudate.
V75097 Amaroswerin 21233-18-1 Amaroswerin is a bioactive thioiridoid glycoside found in Swertia swine.
V75094 Aminopicoline (Ascensil) 695-34-1 Aminopicoline (Ascensil) is a potent and non-selective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS).
V75121 Anhydrotoptol 88206-51-3 Anhydronotoptol is a potent inhibitor of nitric oxide production.
Contact Us Back to top