A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V108188 | Rabdoternin E | 155969-82-7 | Rabdoternin E is a potential anti-inflammatory and anti-tumor drug. |
|
V114399 | L-Arginine arginine | 37466-21-0 | L-arginine is a substrate for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). |
|
V116746 | 1-O-Caffeoylglycerol | 123134-23-6 | 1-O-Caffeoylglycerol is a compound with anti-inflammatory activity found in sorghum (Sorghum bicolor). |
|
V116931 | GW 273629 | 250599-60-1 | GW 273629 is a selective nitric oxide synthase inhibitor with anti-inflammatory effects. |
|
V117032 | SCR-4026 | 2185855-51-8 | SCR-4026 is a neuroprotective agent that can cross the blood-brain barrier. |
|
V108084 | 2α-Acetoxy-14,15-cyclopimara-7β,16-diol | 2011034-27-6 | 2α-Acetoxy-14,15-Cyclopimal-7β,16-diol (compound 2) is a potential anti-inflammatory agent that exerts weak anti-inflammatory activity by inhibiting inflammation-related NO production. |
|
V108111 | Stephalonine P | 2376309-57-6 | Stefanin P is a fimbriae-type alkaloid with anti-inflammatory properties and a protective effect against neuroinflammation. |
|
V108830 | Myricadenin A | 1612239-23-2 | Myricetin A is an iNOS inhibitor that can effectively inhibit NO production (EC₅₀ = 18.1 μM). |
|
V112695 | Cicletanine hydrochloride | 82747-56-6 | Cialis hydrochloride is an orally effective furanylpyridine antihypertensive drug. |
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V115532 | FR144420 | 162626-99-5 | FR144420 (NOR4) is an orally effective nitric oxide (NO) releaser with vasodilatory and antiplatelet aggregation effects. |
|
V120064 | NO-Rosa5 chloride | NO-Rosa5 (chloride) is a photosensitive NO donor. | |
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V113251 | 2-Oxostenine | 18058-98-5 | 2-Oxysteroidane (compound 7) is a sterane alkaloid found in the roots of Stemona tuberosa Lour. |
|
V116441 | Aminoguanidine-13C, 15N4 | 478189-68-3 | Aminoguanidine-13C,15N4 (pimagazidin-13C,15N4) is the 13C and 15N notated form of aminoguanidine. |
|
V112479 | 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone | 123999-38-2 | 2,4-Dihydroxy-6-methoxy-3,5-diisopentenylacetophenone (compound 8) is an acetophenone derivative found in *Acronychia oligophlebia*. |
|
V120306 | L-ENIPO hydrochloride | 1821706-67-5 | L-ENIPO (hydrochloride) is an inhibitor of iNOS, nNOS, and eNOS, with Ki values of 17, 10.3, and 58.2 μM, respectively. |
|
V115678 | NXN-188 | 915036-97-4 | NXN-188 is an nNOS inhibitor and a 5HT-1B/1D receptor agonist. |
|
V115620 | Circumdatin C | 223130-61-8 | Cyclosin C is an alkaloid. |
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V115541 | KLYP961 | 1125746-49-7 | KLYP961 is a selective, orally effective dual inhibitor of inducible and neuronal nitric oxide synthase (NO synthase) (IC50 value 50-400 nM). |
|
V115803 | RC-552 | 253119-91-4 | RC-552 is a novel synthetic glycolipid whose chemical structure is related to MLA. |
|
V109595 | Balanophonin B | 92216-41-6 | Baranofenine B is a selective inhibitor (IC50 = 1.46 μg/mL) that targets the lipopolysaccharide (LPS)-induced nitric oxide (NO) production pathway and can be isolated from Dendrobium pachylepis. |
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