A group of enzymes known as nitric oxide synthases (NOSs) are responsible for producing nitric oxide (NO) from L-arginine. L-arginine is oxidized to produce NO and L-citrulline by NO synthases. Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) are the three NOS isoforms found in mammals. Numerous physiological processes in the nervous, immune, and cardiovascular systems involve NO produced by these various NOS isoforms. Pathologic conditions such as stroke, inflammation, and hypertension can result from uncontrolled NO production. As a result, isoform-specific NOS inhibitors have a lot of potential as therapeutic treatments for diseases linked to NO.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75149 | (+)-Hannokinol | 408324-76-5 | (+)-Hannokinol can be extracted from the fruits of AMOMUM TSAO-KO (Zingiberaceae). |
|
V84404 | (+)-Rhododendrol ((S)-(+)-Rhododendrol; (+)-Betuligenol) | 59092-94-3 | |
|
V75146 | (-)-10,11-Dihydroxyfarnesol | 37133-76-9 | (-)-10,11-Dihydroxyfarnesol is a compound extracted from the endophytic fungus Cryptomarasmius aucubae. |
|
V71565 | (Rac)-Zevaquenabant ((Rac)-MRI-1867) | 1610420-28-4 | (Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a CB1R/iNOS dual-targeting inhibitor (antagonist) with a Ki of 5.7 nM for CB1R. |
|
V77363 | (Rac)-ZLc-002 | (Rac)-ZLc-002 is an inhibitor (blocker/antagonist) of the interaction between nNOS and nitric oxide synthase 1 adapter protein (NOS1AP), inhibits inflammatory pain and chemotherapy-induced neuropathic pain, and synergizes with Paclitaxel to reduce tumor cell viability. | |
|
V75092 | (S)-ZLc002 | 308277-46-5 | (S)-ZLc002 is the S-enantiomer of ZLc-002. |
|
V84184 | 1400W (W1400) | 180001-34-7 | |
|
V2716 | 1400W 2HCl | 214358-33-5 | 1400W (1400-W) is a slow, tight binding, potent, and highlyselective inhibitor of inducible nitric-oxide synthase (iNOS) withKivalues of 7 nM. |
|
V83602 | 3,4-DAA | 2117759-07-4 | |
|
V75095 | 3-Amino-1,2,4-triazine | 1120-99-6 | 3-Amino-1,2,4-triazine is a NO synthase inhibitor and can also inhibit the secretion of nitrite. |
|
V75119 | 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid | 168293-14-9 | 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is a triterpenoid with anti~inflammatory activity. |
|
V75125 | 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) | 23050-38-6 | 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether) comes from Andrographis paniculata and can inhibit NO with IC50 of 39.1 μM. |
|
V75135 | 6-Methoxynaringenin | 94942-49-1 | 6-Methoxynaringenin is a naturally occurring flavonoid that can inhibit NO production with IC50 of 25.8 μM. |
|
V75122 | 8A8 | 2766594-12-9 | 8A8 is a potent inhibitor of the pro-inflammatory factor NO with IC50 of 4.7 μM. |
|
V75152 | 9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) | 22333-58-0 | 9-Hydroxy-α-lapachone (α-DiHydrocaryopterone) is a natural phenol that potently inhibits LPS-induced NO production in RAW 264.7 cells with IC50 of 4.64 µM. |
|
V75127 | Alismol | 87827-55-2 | Alismol is a natural sesquiterpene. |
|
V75110 | Aloenin aglycone | 59163-53-0 | Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be extracted from aloe exudate. |
|
V75097 | Amaroswerin | 21233-18-1 | Amaroswerin is a bioactive thioiridoid glycoside found in Swertia swine. |
|
V75094 | Aminopicoline (Ascensil) | 695-34-1 | Aminopicoline (Ascensil) is a potent and non-selective inhibitor of NO synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). |
|
V75121 | Anhydrotoptol | 88206-51-3 | Anhydronotoptol is a potent inhibitor of nitric oxide production. |
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