FBPase is a rate-limiting enzyme that catalyzes the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. It also regulates gluconeogenesis and glyconeogenesis, as well as glucose homeostasis and energy metabolism more broadly. Mammals have two distinct genes, FBP1 and FBP2, that, respectively, code for the liver and muscle isoforms of FBPase.
Poorer prognoses for cancer patients were frequently significantly correlated with lower FBPase expression, advanced tumour stage, and highly malignant phenotype. All of these findings suggested that FBPase might be a brand-new biomarker and potential cancer treatment target.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V133609 | D-Fructose-6-phosphate disodium hydrate | 918149-30-1 | D-Fructose-6-phosphate disodium hydrate is an endogenous metabolite. |
|
V94437 | FBPase-IN-3 | FBPase-IN-3 (Compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with IC50 of 2.08 μM. | |
|
V104416 | FBPase-IN-4 | FBPase-IN-4 (Compound 11 n) is a potent FBPase (fructose-1,6-bisphosphatase) inhibitor with Ki value of 1.78 μM. | |
|
V109252 | FBPase-IN-6 | FBPase-IN-6 (compound 96) is an orally effective FBPase inhibitor with an IC50 value of 1.769 μM. | |
|
V135810 | FBPase-IN-7 | FBPase-IN-7 is a fructose-1,6-bisphosphatase (FBPase) inhibitor with an IC50 value of 0.75 μM. | |
|
V2344 | Fructose-1 | 883973-99-7 | FBPase-1 inhibitor-1 (compound 1) is an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). |
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