In homologous recombination (HR), a crucial eukaryotic DNA recombinase called RAD51 encourages homologous pairing and strand exchange in addition to the recombinational repair of double strand breaks. The homopolymeric filaments created by RAD51 protein, which is attracted to the DNA break by BRCA2, invade the homologous chromatid and use it as a template for repair. The presence of RAD51 filaments, which can be seen by immunofluorescence as distinct foci in the cell nucleus, serves as a readout of HR competence. RAD51 is a crucial gene that guards against genetic instability in cells.
The activity of the RAD51 recombinase is essential for the survival and proliferation of cancer cells, and it frequently results in drug resistance. Breast cancer and chronic myeloid leukemia (CML) have been found to have abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates. Therefore, RAD51 direct targeting and RAD51 activity attenuation have been suggested as an additional and alternative cancer treatment method.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V122019 | (Rac)-IBR120 | 1996673-44-9 | (Rac)-IBR120 is the racemic form of IBR120. |
|
V130616 | BRCA2-RAD51-IN-2 | BRCA2-RAD51-IN-2 is a BRCA2-RAD51 inhibitor that, when used in combination with 10 µM olaparib, inhibits homologous recombination repair. | |
|
V130617 | BRCA2-RAD51-IN-3 | BRCA2-RAD51-IN-3 is a RAD51-BRCA2 protein-protein interaction inhibitor with an EC50 of 29.35 μM and a Kd of 75.14 μM. | |
|
V132512 | CSN5-IN-2 | CSN5-IN-2 is a CSN5 inhibitor with an IC50 value of 0.36 μM. | |
|
V133616 | D-G23 | 1225141-73-0 | D-G23 is a selective RAD52 inhibitor. |
|
V137228 | HDAC-IN-85 | HDAC-IN-85 is an HDAC inhibitor that can cross the blood-brain barrier. | |
|
V34723 | Homologous recombination-IN-1 | 391889-85-3 | Homologous recombination-IN-1 is a potent inhibitor of the protein-protein interaction between RAD51 and BRCA2 (EC50=19 μM) that can obstruct homologous recombination. |
|
V2471 | RAD51-IN-1 | 2101739-18-6 | RAD51-IN-1 is an analogue of B02 and a potent inhibitor of RAD51. |
|
V55225 | RAD51-IN-3 | 2301084-99-9 | RAD51-IN-3 is a Rad51 inhibitor. |
|
V143781 | RAD51-IN-9 | 103056-35-5 | RAD51-IN-9 is a RAD51 inhibitor that inhibits the binding of RAD51 to single-stranded DNA, with an IC50 value of 17.85 μM. |
|
V1951 | RI-1 | 415713-60-9 | RI-1 (also known as RAD51 inhibitor 1) is an irreversible small molecule inhibitor of RAD51 with IC50 ranging from 5 to 30 μM. |
|
V32929 | RI-2 | 1417162-36-7 | RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells. |
|
V3039 | RS-1 | 312756-74-4 | RS-1 (formerly known as RAD51-Stimulatory Compound-1) is a small molecule RAD51 activator that enhances hRAD51 binding in a wide range of biochemical conditions. |
|
V144805 | SeSA-HCPT | SeSA-HCPT is an orally effective dual-target inhibitor that integrates the inhibitory effects of topoisomerase I and histone deacetylase (HDAC). | |
|
V145497 | SZU305 | SZU305 is a RAD51 PROTAC degrader with DC50 values of 307.45 nM and 84.19 nM in SK-HEP-1 and Huh-7 cells, respectively. |
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