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Acyltransferase

Acyltransferase

Acyl-coenzyme A (acyl-CoA) transfers an acyl moiety to an acceptor through the action of the enzyme acyltransferase (AT). Acyltransferases have been connected to a number of diseases and are crucial for the maintenance of homeostasis in the human body. The acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) are members of the acyltransferase family, which is involved in the metabolism of lipids.

ACAT (acyl-coenzyme A:cholesterol acyltransferase) is an intracellular enzyme that facilitates the conversion of cholesterol and fatty acyl-coenzyme A into cholesterol esters. ACAT1 and ACAT2, two isoenzymes that are encoded by separate genes, are found in mammals. In many tissues, ACATs are crucial for maintaining cellular cholesterol homeostasis.

DGAT (acyl-CoA:diacylglycerol acyltransferase) is an integral membrane enzyme that catalyzes the final step of triacylglycerol synthesis from diacylglycerol and acyl-CoA. Two distinct membrane-bound polypeptides, known as DGAT1 and DGAT2, are where the majority of the DGAT activity is found.

MGAT (acyl-CoA:monoacylglycerol acyltransferase) catalyzes the synthesis of diacylglycerol, the precursor of physiologically significant lipids like triacylglycerol and phospholipids. Because the assembly of the lipoproteins that carry absorbed fat to other tissues depends on the resynthesis of triacylglycerol, MGAT plays a significant role in the absorption of dietary fat in the intestine.

Acyltransferase related products

Structure Cat No. Product Name CAS No. Product Description
(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid V104726 (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid 1809064-89-8 (R)-2-(3-(2-ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic acid is an intermediate for the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat.
(Rac)-OSMI-1 V73890 (Rac)-OSMI-1 2748153-92-4 (Rac)-OSMI-1 is the racemate of OSMI-1.
16-NBD-16:0 Coenzyme A triammonium V87270 16-NBD-16:0 Coenzyme A triammonium 1367862-09-6 16-NBD-16:0 Coenzyme A triammonium can be used as a substrate to measure the activity of other acyltransferases in vitro.
447C88 V114592 447C88 130400-16-7 447C88 is an acyl-CoA cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM.
AANAT-IN-1 V84643 AANAT-IN-1
AANAT-IN-2 V113258 AANAT-IN-2 AANAT-IN-2 (compound 5g) is a potent and selective AANAT inhibitor with an IC50 of 1.1 μM.
ABT-046 V4405 ABT-046 1031336-60-3 ABT-046 is a novel, potent, selective, and orally bioavailableinhibitor of diacylglycerol acyltransferase 1 (DGAT-1 ) with IC50 of 8 nM.
ACAT-IN-10 V73905 ACAT-IN-10 454203-40-8 ACAT-IN-10 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-10 dihydrochloride V73898 ACAT-IN-10 dihydrochloride 199983-77-2 ACAT-IN-10 di-HCl is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-2 V73895 ACAT-IN-2 199984-55-9 ACAT-IN-2 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-3 V73892 ACAT-IN-3 454203-25-9 ACAT-IN-3 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-4 V73907 ACAT-IN-4 454203-56-6 ACAT-IN-4 (Example 208) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-4 hydrochloride V73900 ACAT-IN-4 hydrochloride 199984-46-8 ACAT-IN-4 HCl (Example 208) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-5 V73906 ACAT-IN-5 199983-93-2 ACAT-IN-5 (example 19) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-6 V73891 ACAT-IN-6 454203-45-3 ACAT-IN-6 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-7 V73893 ACAT-IN-7 199984-38-8 ACAT-IN-7 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-8 V73899 ACAT-IN-8 199984-35-5 ACAT-IN-8 (example 206) is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
ACAT-IN-9 V73894 ACAT-IN-9 199984-40-2 ACAT-IN-9 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
AGPAT4-IN-1 V118565 AGPAT4-IN-1 2411250-59-2 AGPAT4-IN-1 (compound CL26) is a covalent AGPAT4 inhibitor with an IC50 value of 795 nM.
BMS-963272 V73887 BMS-963272 1441057-15-3 BMS-963272 is a potent and specific MGAT2 inhibitor (IC50 = 7.1 nM) for studying metabolic disorders.
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