IKK is a complex composed of three subunits: IKKα, IKKβ, and IKKγ (also called NEMO).The complex serves as the center of signal integration for activating NF-B. In order to catalyze the phosphorylation of numerous I-B and NF-B proteins as well as other substrates, it combines signals from all NF-B activating stimuli. The IKKs IKK-alpha and IKK-beta, as well as the IKK-related kinases TBK1 and IKK-epsilon, make up the four members of the human IKK family.
The so-called canonical members, IKK-1 and IKK-2, phosphoryate I-B, activating the transcription factor NF-B, which in turn regulates the expression of several immunological and inflammatory genes. IRF3, a distinct substrate of the IKK-related proteins TBK-1 and IKK-epsilon, controls a separate set of genes, the byproducts of which include Type I interferons. Due to their critical roles in numerous biological processes, such as the immunological response, the stress response, and tumor growth, IKKs are a therapeutic target.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82229 | 6-keto Prostaglandin F1α | 58962-34-8 | 6-keto Prostaglandin F1α is an endogenously produced metabolite present in cerebrospinal fluid, urine and blood and may be utilized to study meningitis, rheumatoid arthritis and cardiopulmonary resuscitation. |
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V30592 | ACHP Hydrochloride | 406209-26-5 | ACHP hydrochloride(also known as IKK-2 Inhibitor VIII), thehydrochloride salt of ACHP, is a novel, highly potent and selective IKK-β inhibitor with IC50 of 8.5 nM. |
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V0756 | AZD3264 | 1609281-86-8 | AZD3264 (AZD-3264; AZD 3264) is a novel and potent inhibitor of IKK2 (IkappaBKinase/(IκB) with potential anti-inflammatory and anticancer activity. |
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V0749 | BAY 11-7082 | 19542-67-7 | BAY 11-7082 (BAY-11-7082; BAY-117082) is a novel and potent NF-κB inhibitor with potential anti-inflammatory and anticancer activity. |
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V0760 | Bay 11-7085 | 196309-76-9 | BAY 11-7085 (BAY-11-7085; BAY 117085) is a novel, potent, soluble, irreversible inhibitor of TNFα-induced IκBα phosphorylation with potential anticancer activity. |
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V4190 | Bay 65-1942 | 600734-02-9 | BAY65-1942 is a novel, potent and selective ATP-competitive inhibitor ofIKKβ. |
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V4191 | Bay 65-1942 R-isomer | 758683-21-5 | Bay 65-1942 R-isomer is the R-enantiomeric isomer of BAY65-1942 which is a novel, potent and selective ATP-competitive inhibitor ofIKKβ. |
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V4704 | BI-605906 | 960293-88-3 | BI605906 (BI-605906) is a novel and potent IKKβinhibitor with anti-Inflammatory Effects. |
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V0755 | BMS-345541 | 445430-58-0 | BMS-345541 (BMS345541; BMS 345541) is a novel, highly potent andselectiveIKK-1/2inhibitorwith potential anticancer and anti-inflammatory activity. |
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V30197 | BMS-345541 HCl | 547757-23-3 | BMS-345541 HCl is a novel, cell-permeable and selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively. |
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V82227 | Cerebroside D | 113773-89-0 | Cerebroside D is a glycosylceramide compound with multiple targets on activated T lymphocytes and can improve experimental colitis in mice. |
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V51201 | DMX-129 | 1623123-95-4 | DMX-129 is an inhibitor (blocker/antagonist) of ΙΚΚε and TBK-1 with IC50 less than 30 nM. |
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V20694 | Ertiprotafib | 251303-04-5 | Ertiprotafib (PTP-112; PTP112) is a novel and potent Protein Tyrosine Phosphatase 1B Inhibitor (PTP1B inhibitor) with the ability tonormalize the plasma glucose and insulin levels in diabetic animal models. |
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V3566 | GSK319347A | 862812-98-4 | GSK319347A is a novel, potent and dual inhibitor ofTBK1andIKKεwithIC50s of 93 nM and 469 nM, respectively. |
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V0750 | IKK-16 (IKK Inhibitor VII; IKK 16) | 873225-46-8 | IKK-16 (also known as IKK Inhibitor VII; IKK-16; IKK16) is a novel, potent and selective IκBα kinase (IKK) inhibitor with potential anti-inflammatory activity. |
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V87867 | IKKβ-IN-3 | IKKβ-IN-3 (Compound hit4) is an IKKβ inhibitor with IC50 of 30.4 nM. | |
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V87868 | IKKβ-IN-4 | 4815-35-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β (ikkβ) inhibitor with IC50 of 1.9 μM. |
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V0752 | IMD 0354 | 978-62-1 | IMD-0354 (IMD0354; IMD-0354) is a novel, potent and selective IKKβ inhibitorwith potential anti-inflammatory activity. |
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V4604 | INH-14 | 200134-22-1 | INH14 is a novel, potent and cell permeable inhibitor ofIKKα/IKKβ, withIC50s of 8.97 and 3.59 μM, respectively. |
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V82228 | Keap1-Nrf2-IN-7 | 2769963-42-8 | Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor (antagonist) with IC50 of 0.45 µM. |
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