Farnesyl transferase is a zinc-dependent enzyme that catalyzes the attachment of a farnesyl lipid group to a cysteine residue of a variety of proteins involved in cell signaling, including the cancer-causing H-Ras protein. Farnesyl transferase controls how the Ras protein is activated, which has an impact on intracellular signaling, cell growth, and proliferation.
An important enzyme in the mevalonate (MVA) pathway is farnesyl transferase. Ras protein, which depends on farnesylation anchoring itself in membrane, is coupled to farnesyl pyrophosphate (FPP), and farnesyl transferase catalyzes the farnesyl moieties of FPP. Small molecules called farnesyl transferase inhibitors target specific intracellular substrate proteins like Ras and prevent them from being farnesylated. A new class of drugs called farnesyl transferase inhibitors targets the signal transduction pathways necessary for the survival and proliferation of various malignant cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51477 | (Rac)-Lonafarnib (Sch-66336 racemate) | 193275-86-4 | (Rac)-Lonafarnib (Sch66336 racemate) is the racemate of Lonafarnib. |
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V9970 | ABT-100 | 450839-40-4 | ABT-100 (ABT100) is a novel and potent farnesyltransferase inhibitor with abroad-spectrum antitumor activity. |
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V73156 | Andrastin A | 174232-42-9 | Andrastin, a terpenoid, is a farnesyltransferase inhibitor. |
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V3486 | BMS-214662 | 195987-41-8 | BMS-214662 is a novel, potent and selective inhibitor offarnesyl transferase (FT)with potential antitumor activity and anIC50of 1.35 nM. |
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V3986 | CP-609754 (OSI754, LNK 754) | 1190094-64-4 | OSI754 (also known as CP-609754, CP-609,754, LNK-754) is a novel and potent farnesyltransferase inhibitor (TFI) that has potential anticancer activity. |
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V73153 | FGTI-2734 mesylate | 2702297-24-1 | FGTI-2734 mesylate is an inhibitor (blocker/antagonist) of RAS C-terminal farnesyl transferase (FT) and geranyl transferase-1 (GGT), with IC50s of 250 nM and 520 nM for FT and GGT, respectively. |
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V73155 | Ftase inhibitor III | 2710375-18-9 | Ftase inhibitor III is a phenotypicly screened anion-dependent Farnesyltransferase inhibitor. |
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V21386 | FTI-2148 | 251577-09-0 | FTI-2148,a RAS C-terminal mimetic, is a novel, potent and highly selective dual inhibitor offarnesyl transferase (FT-1)andgeranylgeranyl transferase-1 (GGT-1)withIC50s of 1.4 nM and 1.7 μM, respectively. |
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V73154 | FTI-2153 TFA | 2820151-01-5 | FTI-2153 TFA is a specific farnesyltransferase (FTase) inhibitor (antagonist) with IC50 of 1.4 nM. |
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V4632 | L-778123 hydrochloride | 253863-00-2 | L-778123 (L778123) hydrochloride is a novel and potent inhibitor of FPTase (Farnesyl:protein transferase) and GGPTase-I (geranylgeranyl:protein transferase type-I) (IC50 = 2 nM and 98 nM) with anticancer activity. |
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