Integral membrane proteins called serotonin transporters (SERTs) move serotonin from synaptic spaces into presynaptic neurons. Serotonin's function is effectively terminated and neuronal transmission is stopped by SERTs, which reabsorb it in the synaptic cleft. Reuptake of serotonin is essential for avoiding nerve overstimulation.
By delivering 5-hydroxytryptamine (5HT) to neurons and glial cells, the serotonin transporter (SERT) controls the extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain. Drugs used to treat emotional disorders, such as depression, primarily target the human SERT (hSERT). The bacterial leucine transporter (LeuT), for which a high resolution crystal structure is now available, is a member of the solute carrier 6 family, which also includes hSERT.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V87838 | (1S,4S)-N-Desmethyl Sertraline hydrochloride | 675126-10-0 | (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline. |
|
V70013 | (R)-Fluoxetine hydrochloride ((R)-Fluoxetine hydrochloride) | 114247-09-5 | (R)-Fluoxetine HCl, an antidepressant, is a serotonin reuptake inhibitor (SSRI). |
|
V70010 | (S)-Fluoxetine hydrochloride (S-isomer of fluoxetine) | 114247-06-2 | (S)-Fluoxetine HCl is an antidepressant and serotonin reuptake inhibitor (SSRI). |
|
V70005 | (±)-cis-Sertraline-d3 hydrochloride ((±)-Sertraline d3 hydrochloride (hydrochloride)) | 1217741-83-7 | (±)-cis-Sertraline-d3 ( HCl) is the deuterated form of Sertraline HCl. |
|
V70022 | (±)-Duloxetine hydrochloride ((Rac)-Duloxetine hydrochloride) | 947316-47-4 | (±)-Duloxetine ((Rac)-Duloxetine) HCl is the racemate of Duloxetine HCl. |
|
V70026 | Adoxosidic acid | 84375-46-2 | Adoxosidic acid is a SERT enhancer found in N. |
|
V70016 | Ampreloxetine hydrochloride (TD-9855 hydrochloride) | 1227056-87-2 | Ampreloxetine (TD-9855) HCl is an orally bioactive and CNS-penetrating inhibitor of the norepinephrine transporter (NET) and the serotonin 5-HT uptake transporter (SERT), but not the dopamine transporter (DAT). |
|
V70003 | Bupropion-d9 hydrochloride (Amfebutamone-d9 (hydrochloride)) | 1189725-26-5 | Bupropion-d9 ( HCl) is the deuterated form of Bupropion HCl. |
|
V2001 | Cinchonidine | 485-71-2 | Cinchonidine (α-Quinidine) is a cinchoni alkaloid found in cinchona and mugwort. |
|
V70011 | Citalopram-d4 hydrobromide (Citalopram-d4 (bromide)) | 1219803-58-3 | Citalopram-d4 (HBr) is the deuterium labelled form of Citalopram HBr, a selective serotonin reuptake inhibitor (SSRI). |
|
V70014 | Clomipramine-d6 hydrochloride (Chlorimipramine-d6 (hydrochloride); G-34586-d6 (hydrochloride); NSC-169865-d6 (hydrochloride)) | 1189882-28-7 | Clomipramine-d6 ( HCl) is the deuterated form of Clomipramine HCl. |
|
V70024 | Clovoxamine (DU23811) | 54739-19-4 | Clovoxamine (DU23811) (Compound 35) has binding affinity (Ki: 61 nM) for serotonin transporter (SERT). |
|
V2504 | Dapoxetine | 119356-77-3 | Dapoxetine (LY-210448) is an orally bioactive selective serotonin reuptake inhibitor (SSRI). |
|
V70018 | Dapoxetine-d6 | 1132642-58-0 | Dapoxetine-d6 is the deuterated form of Dapoxetine. |
|
V77105 | Dapoxetine-d7 hydrochloride (LY-210448-d7 (hydrochloride)) | Dapoxetine-d7 ( HCl) is the deuterated form of Dapoxetine HCl. | |
|
V19190 | Dasotraline HCl | 675126-08-6 | Dasotraline (formerly known as SEP-225289;SEP-225,289) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with anti-depressant and anti-ADHD activity. |
|
V70019 | Desmethyl Sibutramine (N-Desmethylsibutramine) | 168835-59-4 | Desmethyl Sibutramine is a secondary metabolite (SM, chemical compound) of Sibutramine and an inhibitor (blocker/antagonist) of norepinephrine transporter (NET) and serotonin transporter (SERT). |
|
V70020 | Desmethyl Sibutramine hydrochloride (N-Desmethylsibutramine hydrochloride) | 84467-94-7 | Desmethyl Sibutramine HCl is a secondary metabolite (SM, chemical compound) of Sibutramine and an inhibitor (blocker/antagonist) of norepinephrine transporter (NET) and serotonin transporter (SERT). |
|
V70025 | Desvenlafaxine-d10 | 1062607-49-1 | Desvenlafaxine-d10 is the deuterium labelled form of Desvenlafaxine. |
|
V70021 | Desvenlafaxine-d6 (O-desvenlafaxine d6) | 1062605-69-9 | Desvenlafaxine-d6 is the deuterium labelled form of Desvenlafaxine. |
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