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Serotonin Transporter

Serotonin Transporter

Integral membrane proteins called serotonin transporters (SERTs) move serotonin from synaptic spaces into presynaptic neurons. Serotonin's function is effectively terminated and neuronal transmission is stopped by SERTs, which reabsorb it in the synaptic cleft. Reuptake of serotonin is essential for avoiding nerve overstimulation.

By delivering 5-hydroxytryptamine (5HT) to neurons and glial cells, the serotonin transporter (SERT) controls the extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain. Drugs used to treat emotional disorders, such as depression, primarily target the human SERT (hSERT). The bacterial leucine transporter (LeuT), for which a high resolution crystal structure is now available, is a member of the solute carrier 6 family, which also includes hSERT.

Serotonin Transporter related products

Structure Cat No. Product Name CAS No. Product Description
(1S,4S)-N-Desmethyl Sertraline hydrochloride V87838 (1S,4S)-N-Desmethyl Sertraline hydrochloride 675126-10-0 (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline.
(R)-Duloxetine hydrochloride V105612 (R)-Duloxetine hydrochloride 910138-96-4 (R)-Duloxetine (LY248686) hydrochloride is a naphthoxy-substituted amine used in binding studies to human serum albumin and, unlike its enantiomer (S)-duloxetine, has limited efficacy as a dual serotonin and norepinephrine reuptake inhibitor (SNRI).
(R)-Fluoxetine hydrochloride ((R)-Fluoxetine hydrochloride) V70013 (R)-Fluoxetine hydrochloride ((R)-Fluoxetine hydrochloride) 114247-09-5 (R)-Fluoxetine HCl, an antidepressant, is a serotonin reuptake inhibitor (SSRI).
(S)-Fluoxetine hydrochloride (S-isomer of fluoxetine) V70010 (S)-Fluoxetine hydrochloride (S-isomer of fluoxetine) 114247-06-2 (S)-Fluoxetine HCl is an antidepressant and serotonin reuptake inhibitor (SSRI).
(S)-Norfluoxetine V103032 (S)-Norfluoxetine 126924-38-7 (S)-Norfluoxetine, the S enantiomer of norfluoxetine, is a selective serotonin reuptake inhibitor.
(±)-cis-Sertraline-d3 hydrochloride ((±)-Sertraline d3 hydrochloride (hydrochloride)) V70005 (±)-cis-Sertraline-d3 hydrochloride ((±)-Sertraline d3 hydrochloride (hydrochloride)) 1217741-83-7 (±)-cis-Sertraline-d3 ( HCl) is the deuterated form of Sertraline HCl.
(±)-Duloxetine hydrochloride ((Rac)-Duloxetine hydrochloride) V70022 (±)-Duloxetine hydrochloride ((Rac)-Duloxetine hydrochloride) 947316-47-4 (±)-Duloxetine ((Rac)-Duloxetine) HCl is the racemate of Duloxetine HCl.
2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride V118462 2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride 63199-74-6 2-(tert-butylamino)-1-phenylprop-1-one hydrochloride (compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist.
6-Nitroquipazine V113667 6-Nitroquipazine 77372-73-7 6-Nitroquinazine (DU24565) is a potent and selective 5-HT transporter inhibitor with a Ki value of 0.17 nM.
9β-Debilon V102873 9β-Debilon 9β-Debilon is a sesquiterpenoid found in Nardostachys grandiflora that may have SERT modulatory activity.
Adoxosidic acid V70026 Adoxosidic acid 84375-46-2 Adoxosidic acid is a SERT enhancer found in N.
Ampreloxetine hydrochloride (TD-9855 hydrochloride) V70016 Ampreloxetine hydrochloride (TD-9855 hydrochloride) 1227056-87-2 Ampreloxetine (TD-9855) HCl is an orally bioactive and CNS-penetrating inhibitor of the norepinephrine transporter (NET) and the serotonin 5-HT uptake transporter (SERT), but not the dopamine transporter (DAT).
Bupropion-d9 hydrochloride (Amfebutamone-d9 (hydrochloride)) V70003 Bupropion-d9 hydrochloride (Amfebutamone-d9 (hydrochloride)) 1189725-26-5 Bupropion-d9 ( HCl) is the deuterated form of Bupropion HCl.
Citalopram-d4 hydrobromide (Citalopram-d4 (bromide)) V70011 Citalopram-d4 hydrobromide (Citalopram-d4 (bromide)) 1219803-58-3 Citalopram-d4 (HBr) is the deuterium labelled form of Citalopram HBr, a selective serotonin reuptake inhibitor (SSRI).
Clemeprol V114320 Clemeprol 71827-56-0 Klebspray (BRL 14342) is an orally effective inhibitor of norepinephrine (NA) and serotonin (5-HT) reuptake.
Clomipramine-d6 hydrochloride (Chlorimipramine-d6 (hydrochloride); G-34586-d6 (hydrochloride); NSC-169865-d6 (hydrochloride)) V70014 Clomipramine-d6 hydrochloride (Chlorimipramine-d6 (hydrochloride); G-34586-d6 (hydrochloride); NSC-169865-d6 (hydrochloride)) 1189882-28-7 Clomipramine-d6 ( HCl) is the deuterated form of Clomipramine HCl.
Clovoxamine (DU23811) V70024 Clovoxamine (DU23811) 54739-19-4 Clovoxamine (DU23811) (Compound 35) has binding affinity (Ki: 61 nM) for serotonin transporter (SERT).
DA-8031 V104228 DA-8031 1148027-74-0 DA-8031 is a selective oral serotonin reuptake inhibitor.
Dapoxetine-d6 V70018 Dapoxetine-d6 1132642-58-0 Dapoxetine-d6 is the deuterated form of Dapoxetine.
Dapoxetine-d7 V110720 Dapoxetine-d7 1132642-56-8 Dapoxetine-d7 (LY-210448-d7) is a deuterated dapoxetine.
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