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Serotonin Transporter

Serotonin Transporter

Integral membrane proteins called serotonin transporters (SERTs) move serotonin from synaptic spaces into presynaptic neurons. Serotonin's function is effectively terminated and neuronal transmission is stopped by SERTs, which reabsorb it in the synaptic cleft. Reuptake of serotonin is essential for avoiding nerve overstimulation.

By delivering 5-hydroxytryptamine (5HT) to neurons and glial cells, the serotonin transporter (SERT) controls the extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain. Drugs used to treat emotional disorders, such as depression, primarily target the human SERT (hSERT). The bacterial leucine transporter (LeuT), for which a high resolution crystal structure is now available, is a member of the solute carrier 6 family, which also includes hSERT.

Serotonin Transporter related products

Structure Cat No. Product Name CAS No. Product Description
(1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride V121319 (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride 675126-09-7 (1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride is a metabolite of the selective serotonin reuptake inhibitor (SSRI) sertraline.
(1S,4S)-N-Desmethyl Sertraline hydrochloride V87838 (1S,4S)-N-Desmethyl Sertraline hydrochloride 675126-10-0 (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline.
(R)-Duloxetine hydrochloride V105612 (R)-Duloxetine hydrochloride 910138-96-4 (R)-Duloxetine (LY248686) hydrochloride is a naphthoxy-substituted amine used in binding studies to human serum albumin and, unlike its enantiomer (S)-duloxetine, has limited efficacy as a dual serotonin and norepinephrine reuptake inhibitor (SNRI).
(R)-Fluoxetine hydrochloride ((R)-Fluoxetine hydrochloride) V70013 (R)-Fluoxetine hydrochloride ((R)-Fluoxetine hydrochloride) 114247-09-5 (R)-Fluoxetine HCl, an antidepressant, is a serotonin reuptake inhibitor (SSRI).
(R)-Norfluoxetine V121947 (R)-Norfluoxetine 130194-43-3 (R)-Norfluoxetine is the (R)-enantiomer of norfluoxetine.
(S)-Fluoxetine hydrochloride (S-isomer of fluoxetine) V70010 (S)-Fluoxetine hydrochloride (S-isomer of fluoxetine) 114247-06-2 (S)-Fluoxetine HCl is an antidepressant and serotonin reuptake inhibitor (SSRI).
(S)-Norfluoxetine V103032 (S)-Norfluoxetine 126924-38-7 (S)-Norfluoxetine, the S enantiomer of norfluoxetine, is a selective serotonin reuptake inhibitor.
(±)-cis-Sertraline-d3 hydrochloride ((±)-Sertraline d3 hydrochloride (hydrochloride)) V70005 (±)-cis-Sertraline-d3 hydrochloride ((±)-Sertraline d3 hydrochloride (hydrochloride)) 1217741-83-7 (±)-cis-Sertraline-d3 ( HCl) is the deuterated form of Sertraline HCl.
(±)-Duloxetine hydrochloride ((Rac)-Duloxetine hydrochloride) V70022 (±)-Duloxetine hydrochloride ((Rac)-Duloxetine hydrochloride) 947316-47-4 (±)-Duloxetine ((Rac)-Duloxetine) HCl is the racemate of Duloxetine HCl.
2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride V118462 2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride 63199-74-6 2-(tert-butylamino)-1-phenylprop-1-one hydrochloride (compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist.
2-Aminotetralin V124483 2-Aminotetralin 2954-50-9 2-Aminotetralin is a potent and selective 5-HT1 receptor agonist.
3-Chloroamphetamine hydrochloride V125331 3-Chloroamphetamine hydrochloride 35378-15-5 3-Chloroamphetamine hydrochloride is a derivative of amphetamine that acts as a central nervous system stimulant by releasing serotonin and dopamine.
6-Nitroquipazine V113667 6-Nitroquipazine 77372-73-7 6-Nitroquinazine (DU24565) is a potent and selective 5-HT transporter inhibitor with a Ki value of 0.17 nM.
9β-Debilon V102873 9β-Debilon 9β-Debilon is a sesquiterpenoid found in Nardostachys grandiflora that may have SERT modulatory activity.
A6CDQ V127989 A6CDQ 1005550-46-8 A6CDQ is a human organic cation transporter (hOCT) inhibitor with antidepressant-like activity and the ability to cross the blood-brain barrier.
Adoxosidic acid V70026 Adoxosidic acid 84375-46-2 Adoxosidic acid is a SERT enhancer found in N.
Ampreloxetine hydrochloride (TD-9855 hydrochloride) V70016 Ampreloxetine hydrochloride (TD-9855 hydrochloride) 1227056-87-2 Ampreloxetine (TD-9855) HCl is an orally bioactive and CNS-penetrating inhibitor of the norepinephrine transporter (NET) and the serotonin 5-HT uptake transporter (SERT), but not the dopamine transporter (DAT).
Antidepressant agent 9 V129011 Antidepressant agent 9 143899-90-5 Antidepressant agent 9 is an orally effective NMDAR and SERT inhibitor that can cross the blood-brain barrier, with IC50 values of 3.50 μM and 1044 nM, respectively.
BMS-570520 V130399 BMS-570520 388101-58-4 BMS-570520 is a highly bioavailable oral CCR3 antagonist with an IC50 of 1.9 nM for hCCR3 and 1300 nM for hCYP2D6.
Bupropion-d9 hydrochloride (Amfebutamone-d9 (hydrochloride)) V70003 Bupropion-d9 hydrochloride (Amfebutamone-d9 (hydrochloride)) 1189725-26-5 Bupropion-d9 ( HCl) is the deuterated form of Bupropion HCl.
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