Transcriptional regulator The basic helix-loop-helix leucinezipper (bHLHZipper) protein family includes c-Myc. The c-MYC protein's target genes are involved in a variety of cellular processes, including the cell cycle, survival, protein synthesis, cell adhesion, and the expression of microRNAs. In addition, c-Myc, one of the four factors required for the induction of pluripotent stem (iPS) cells from somatic cells, is thought to contribute to the maintenance of cancer stem-like cells (CSCs). The majority of c-Myc'sbiologicalactivities necessitate heterodimerization with its activation partner Max.
Additionally, c-Myc is a component of a dynamic network, which interacts selectively with different transcriptional coregulators, histone-modifying enzymes, and members of the network. Tumorigenesis is linked to c-MYC expression that is dysregulated as a result of gene amplification, retroviral insertion, or chromosomal translocation. One extremely promising target for cancer treatment is c-Myc.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
![]() |
V79917 | c-Myc inhibitor 11 | c-Myc inhibitor 11 (Compound 67e) is a c-MYC inhibitor (pEC50= 6.4). | |
![]() |
V79485 | c-Myc inhibitor 12 | c-Myc inhibitor 12 (compound 67h) is a c-Myc inhibitor (antagonist) with pEC50 of 6.4. | |
![]() |
V2312 | EN4 | 1197824-15-9 | EN4 is a covalent ligand for cysteine 171 (C171) of MYC. |
![]() |
V77917 | MDEG-541 | MDEG-541 is an effective MYC-MAX degrader. | |
![]() |
V76736 | MYC-RIBOTAC | MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) that targets the MYC internal ribosome entry site (IRES). | |
![]() |
V4825 | VPC-70063 | 13571-44-3 | VPC-70063 is a potent Myc-Max inhibitor (antagonist) with IC50 of 8.9 μM for inhibiting Myc-Max transcriptional activity. |