A family of non-selective, single pore-loop, hyperpolarization-activated, six transmembrane domain, hyperpolarization- and cyclic nucleotide-gated (HCN) cation channels. There are four individuals in the HCN family (HCN1-4). I(h), a hyperpolarization-activated current best known for regulating heart rate as well as the resting membrane potential and excitability of neurons, has molecular correlates in HCN channels.
Among vertebrate voltage-gated ion channels, HCN channels are distinctive in that they have a reverse voltage dependence that causes activation upon hyperpolarization. HCN channels are widely expressed throughout the heart and central nervous system and are encoded by four genes (HCN1-4).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V80422 | Ivabradine-d6 (ivabradine-d6) | Ivabradine-d6 is the deuterated form of Ivabradine. | |
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V29094 | Zatebradine (UL-FS-49; UL-FS-49CL) | 85175-67-3 | Zatebradine (UL-FS-49; UL-FS-49CL) is a novel and potent bradycardic agent which inhibitshyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. |
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V26699 | Zatebradine HCl (UL-FS49; UL-FS49CL) | 91940-87-3 | Zatebradine HCl(UL-FS 49; UL-FS 49CL),the hydrochloride salt of Zatebradine, is a novel and potent bradycardic agent which inhibitshyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. |
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V16699 | ZD7288 | 133059-99-1 | ZD7288 (ZD-7288; ZD 7288) is a novel and potent sino-atrial node function modulator that blocks the hyperpolarization activated cation current If(HCN channel). |
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