Sodium-dependent glucose cotransporters (SGLTs) are a family of glucose transporters that aid in the reabsorption of glucose. SGLT1 and SGLT2, which are members of the SLC5A gene family, are the two most well-known members of the SGLT family. The two transporters play a key role in maintaining glucose homeostasis by reabsorbing the filtered glucose in the kidney's tubular system (primarily SGLT2; to a lesser extent via SGLT1) and absorbing glucose from the diet in the small intestine (via SGLT1). This last process replenishes blood glucose levels and reduces urinary glucose loss. The use of SGLT1 and SGLT2 as a novel therapeutic approach for cardiomyopathy and diabetes has been suggested.
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