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Reverse Transcriptase

Reverse Transcriptase

Reverse transcription, also known as cDNA synthesis from an RNA template, is carried out by reverse transcriptases (RTs), an enzyme. To direct the synthesis of the first strand cDNA, reverse transcriptases (RTs) combine an RNA template with a brief primer complementary to the 3' end of the RNA.

Reverse transcriptase, an HIV enzyme, is blocked by nucleoside reverse transcriptase inhibitors (NRTIs). HIV reverse transcriptase is bound to and blocked by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcription is the process by which HIV turns RNA into DNA. HIV cannot replicate when reverse transcriptase and reverse transcription are blocked.

Reverse Transcriptase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Dihydrocalanolide A (DHCal A; NSC 678323) V54257 (+)-Dihydrocalanolide A (DHCal A; NSC 678323) 183904-53-2 (+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally bioavailable, non-nucleoside reverse transcriptase inhibitor.
5'-Azido-5'-deoxythymidine V111563 5'-Azido-5'-deoxythymidine 19316-85-9 5'-Azide-5'-deoxythymidine (compound 7) is a nucleoside analog and belongs to the reverse transcriptase inhibitors.
Alizarin complexone dihydrate V117207 Alizarin complexone dihydrate 455303-00-1 Alizarin dihydrate is the dihydrate of alizarin complex.
BMS-538203 V2865 BMS-538203 543730-41-2 BMS-538203 is a novel and highly efficient HIV integrase inhibitor that is being developed as an antiviral agent.
BMS-707035 V1833 BMS-707035 729607-74-3 BMS-707035 is a novel, potent, specific, and reversible inhibitor of HIV-I integrase (IN) with IC50 of 15 nM.
EFdA-TP tetralithium V88314 EFdA-TP tetralithium EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor.
HIV-1 inhibitor-65 V88317 HIV-1 inhibitor-65 HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC50: 2.9 nM) and an activator of protein kinase C (PKC).
HIV-1 inhibitor-66 V88316 HIV-1 inhibitor-66 HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI).
Inophyllum B ((+)-Inophyllum B) V54261 Inophyllum B ((+)-Inophyllum B) 41135-06-2 Inophyllum B ((+)-Inophyllum B) is a potent HIV reverse transcriptase inhibitor (antagonist) with IC50 of 38 nM.
K-5a2 V117225 K-5a2 1810730-10-9 K-5a2 is a non-isotopic derivative of ZK-316.
Lamivudine triphosphate V88256 Lamivudine triphosphate 143188-53-8 Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (nucleoside analog).
Lamivudine triphosphate TEA V110456 Lamivudine triphosphate TEA 2736455-56-2 Lamivudine triphosphate (3TCTP) TEA is a phosphorylated lamivudine (nucleoside analogue).
M-MLV Reverse transcriptase (M-MLV RT) V54268 M-MLV Reverse transcriptase (M-MLV RT) 9068-38-6 M-MLV Reverse transcriptase (M-MLV RT) is a reverse transcriptase originally developed from Moloneymurineleukemiavirus (MoMLV).
MK-2048 V1834 MK-2048 869901-69-9 MK-2048 is a potent andsecond-generation inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.
MK-8527 V88315 MK-8527 1810869-23-8 MK-8527 is an HIV inhibitor and a nucleoside reverse transcriptase translocation inhibitor (NRTTI).
Niglizin V112084 Niglizin 85734-94-7 Negagliline is a non-competitive reverse transcriptase inhibitor.
NNRT-IN-13 V117274 NNRT-IN-13 NNRT-IN-13 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor that directly inhibits HIV-1 reverse transcriptase (IC₅₀ = 0.25 μM).
NNRT-IN-15 V109192 NNRT-IN-15 NNRT-IN-15 (compound 16a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor.
NNRT-IN-4 V88318 NNRT-IN-4 NNRT-IN-4 (Compound 10p) is a non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 of 0.713 µM for HIV-1 RT.
NNRT-IN-5 V94613 NNRT-IN-5 3032803-00-9 NNRT-IN-5 (compound 10d) is an oral non-nucleoside reverse transcriptase inhibitor.
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