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Reverse Transcriptase

Reverse Transcriptase

Reverse transcription, also known as cDNA synthesis from an RNA template, is carried out by reverse transcriptases (RTs), an enzyme. To direct the synthesis of the first strand cDNA, reverse transcriptases (RTs) combine an RNA template with a brief primer complementary to the 3' end of the RNA.

Reverse transcriptase, an HIV enzyme, is blocked by nucleoside reverse transcriptase inhibitors (NRTIs). HIV reverse transcriptase is bound to and blocked by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcription is the process by which HIV turns RNA into DNA. HIV cannot replicate when reverse transcriptase and reverse transcription are blocked.

Reverse Transcriptase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Dihydrocalanolide A (DHCal A; NSC 678323) V54257 (+)-Dihydrocalanolide A (DHCal A; NSC 678323) 183904-53-2 (+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally bioavailable, non-nucleoside reverse transcriptase inhibitor.
(Z)-Rilpivirine V122307 (Z)-Rilpivirine 500287-94-5 (Z)-Rilpivirine is the (Z)-isomer of rilpivirine.
1,6-Di-O-galloyl-β-D-glucose V122943 1,6-Di-O-galloyl-β-D-glucose 23363-08-8 1,6-Di-O-galloyl-β-D-glucose is a compound found in the fruit of Phyllanthus emblica.
5'-Azido-5'-deoxythymidine V111563 5'-Azido-5'-deoxythymidine 19316-85-9 5'-Azide-5'-deoxythymidine (compound 7) is a nucleoside analog and belongs to the reverse transcriptase inhibitors.
Agrocybin V128415 Agrocybin 544-44-5 Agrocybin is an antifungal peptide that has antifungal activity against a variety of fungi, but no inhibitory activity against bacteria.
Alizarin complexone dihydrate V117207 Alizarin complexone dihydrate 455303-00-1 Alizarin dihydrate is the dihydrate of alizarin complex.
Artoheteronin V129467 Artoheteronin 2771017-28-6 Artoheteronin is an isoprenoid coumarin found in jackfruit.
Asterriquinone V129549 Asterriquinone 60696-52-8 Asterriquinone is an asterriquinone analogue and belongs to the Grb-2 binding inhibitors.
BMS-538203 V2865 BMS-538203 543730-41-2 BMS-538203 is a novel and highly efficient HIV integrase inhibitor that is being developed as an antiviral agent.
BMS-707035 V1833 BMS-707035 729607-74-3 BMS-707035 is a novel, potent, specific, and reversible inhibitor of HIV-I integrase (IN) with IC50 of 15 nM.
Dapivirine-d4 V133199 Dapivirine-d4 1309283-15-5 Dapivirine-d4 is a deuterium-labeled form of dapivirine.
Didanosine-13C2,15N V133745 Didanosine-13C2,15N Didanosine-13C2,15N is didanosine labeled with 13C and 15N.
EFdA-TP tetralithium V88314 EFdA-TP tetralithium EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor.
Emtricitabine-d2 V135059 Emtricitabine-d2 Emtricitabine-d2 is the deuterated form of emtricitabine.
Etravirine-13C3 V135441 Etravirine-13C3 1189671-48-4 Etravirine-13C3 is 13C-labeled etravirine.
Gramine-d2 V136906 Gramine-d2 95415-84-2 Gramine-d2 is a deuterium-labeled Gramine.
HIV RT-IN-2 V137389 HIV RT-IN-2 1909302-89-1 HIV RT-IN-2 is an HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM against HIV-1 RT RNA-dependent DNA polymerase.
HIV-1 inhibitor-65 V88317 HIV-1 inhibitor-65 HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC50: 2.9 nM) and an activator of protein kinase C (PKC).
HIV-1 inhibitor-66 V88316 HIV-1 inhibitor-66 HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI).
HIV-1-IN-83 V137396 HIV-1-IN-83 HIV-1-IN-83 is an HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 value of 0.45 μM against wild-type HIV-1 non-nucleoside reverse transcriptase.
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