FLAP

FLAP

It has been demonstrated that FLAP, or arachidonate 5-lipoxygenase-activating protein, is essential for the production of cellular leukotrienes (LTs) in cells by facilitating the transfer of the substrate arachidonic acid (AA) to 5-lipoxygenase (5-LO). FLAP enables 5-LOX protein to produce oxidized lipid products (primarily eicosanoids) that are crucial for cell growth, differentiation, and death, particularly apoptosis, by transferring arachidonic acid to this enzyme.

FLAP related products

Structure Cat No. Product Name CAS No. Product Description
V74906 (S)-Veliflapon ((S)-BAY X 1005; (S)-DG-031) 128253-32-7
V74905 ALR-27 903639-13-4
V74908 ALR-6 6621-92-7
V74901 Atuliflapon (AZD5718) 2041075-86-7
V74904 FEN1-IN-2 824983-94-0
V74902 FEN1-IN-3 2109805-87-8
V74903 FEN1-IN-5 824983-93-9
V74899 FEN1-IN-6 824983-84-8
V74900 FEN1-IN-7 824983-90-6
V3623 Fiboflapon 936350-00-4 Fiboflapon (also known as AM-803 and GSK2190915) is a novel,orally bioavailable and potent FLAP (5-Lipoxygenase-activating protein) inhibitor with binding IC50of 2.9 nM.
V3624 Fiboflapon Sodium 1196070-26-4 Fiboflapon sodium (also known as AM-803 and GSK2190915 sodium) is a novel,orally bioavailable and potent FLAP (5-Lipoxygenase-activating protein) inhibitor with binding IC50of 2.9 nM.
V79122 LTB4-IN-2
V4328 MK-886 (L-663536) 118414-82-7 MK886 ( also known as L 663536) is a novel and potent5-lipoxygenase-activating proteininhibitor and aleukotriene biosynthesisinhibitor (IC50=2.5 nM).
V4319 MK591 136668-42-3 Quiflapon (formerly known as L-686,70 and MK591 free acid) is a novel, potent, selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50value of 1.6 nM in a FLAP binding assay.
V4320 QUIFLAPON SODIUM (MK591) 147030-01-1 Quiflapon sodium (formerly known as L-686,70 sodium and MK591 sodium) is a novel, potent, selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50value of 1.6 nM in a FLAP binding assay.
V81384 sEH/FLAP-IN-1
Contact Us