It has been demonstrated that FLAP, or arachidonate 5-lipoxygenase-activating protein, is essential for the production of cellular leukotrienes (LTs) in cells by facilitating the transfer of the substrate arachidonic acid (AA) to 5-lipoxygenase (5-LO). FLAP enables 5-LOX protein to produce oxidized lipid products (primarily eicosanoids) that are crucial for cell growth, differentiation, and death, particularly apoptosis, by transferring arachidonic acid to this enzyme.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74906 | (S)-Veliflapon ((S)-BAY X 1005; (S)-DG-031) | 128253-32-7 | (S)-Veliflapon ((S)-BAY X 1005) is an orally bioactive leukotriene biosynthesis and 5-lipoxygenase-activating protein (FLAP) inhibitor. |
|
V74905 | ALR-27 | 903639-13-4 | ALR-27 is an antagonist of 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory effect. |
|
V74908 | ALR-6 | 6621-92-7 | ALR-6 is an antagonist of 5-lipoxygenase (5-LOX) activating protein FLAP and exhibits anti-inflammatory effect. |
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V74901 | Atuliflapon (AZD5718) | 2041075-86-7 | Atuliflapon (AZD5718) is an orally bioactive FLAP (5-lipoxygenase-activating protein) inhibitor (antagonist) with IC50 of 2 nM. |
|
V74904 | FEN1-IN-2 | 824983-94-0 | FEN1-IN-2 (compound 20) is an inhibitor (blocker/antagonist) of endonuclease 1 (FEN1) with IC50s of 3 nM and 226 nM for FEN1 and XPG, respectively. |
|
V74902 | FEN1-IN-3 | 2109805-87-8 | FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. |
|
V74903 | FEN1-IN-5 | 824983-93-9 | FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease 1 (FEN1, IC50=12 nM), involved in DNA damage repair. |
|
V74899 | FEN1-IN-6 | 824983-84-8 | FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease 1 (FEN1, IC50=10 nM), involved in DNA damage repair in mammalian cells. |
|
V74900 | FEN1-IN-7 | 824983-90-6 | FEN1-IN-7 (compound 16) is a selective Flap endonuclease 1 (FEN1, IC50=18 nM) inhibitor that participates in DNA damage repair in mammalian cells. |
|
V3623 | Fiboflapon | 936350-00-4 | Fiboflapon (also known as AM-803 and GSK2190915) is a novel,orally bioavailable and potent FLAP (5-Lipoxygenase-activating protein) inhibitor with binding IC50of 2.9 nM. |
|
V3624 | Fiboflapon Sodium | 1196070-26-4 | Fiboflapon sodium (also known as AM-803 and GSK2190915 sodium) is a novel,orally bioavailable and potent FLAP (5-Lipoxygenase-activating protein) inhibitor with binding IC50of 2.9 nM. |
|
V79122 | LTB4-IN-2 | LTB4-IN-2 (Comopund 6x) is a leukotriene B4 (LTB4) inhibitor. | |
|
V4328 | MK-886 (L-663536) | 118414-82-7 | MK886 ( also known as L 663536) is a novel and potent5-lipoxygenase-activating proteininhibitor and aleukotriene biosynthesisinhibitor (IC50=2.5 nM). |
|
V4319 | MK591 | 136668-42-3 | Quiflapon (formerly known as L-686,70 and MK591 free acid) is a novel, potent, selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50value of 1.6 nM in a FLAP binding assay. |
|
V4320 | QUIFLAPON SODIUM (MK591) | 147030-01-1 | Quiflapon sodium (formerly known as L-686,70 sodium and MK591 sodium) is a novel, potent, selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50value of 1.6 nM in a FLAP binding assay. |
|
V81384 | sEH/FLAP-IN-1 | sEH/FLAP-IN-1 (Compound 46A) is an sEH/FLAP inhibitor. |
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