Humans have a protein called MyD88 that is produced by the MYD88 gene. It is known as the "Myeloid Differentiation Primary Response Gene 88." The evidence suggests that MYD88 is not necessary for human resistance to most pyogenic bacterial infections and common viral infections, highlighting a significant difference between mouse and human immune responses.A crucial adaptor protein in the IL-1R1 signaling pathway is MyD88. A family of signal transduction molecules with a historical role in immune system activation may be defined by MyD88. MyD88 performs the role of a pure adaptor by connecting IL-1R1 to IRAK kinases downstream. Numerous human lymphomas, including the ABC subtype of diffuse large B-cell lymphoma and Waldenstrom's macroglobulinemia, have been found to harbor mutations in MYD88 at position 265 that cause a change from leucine to proline.