Factor Xa, a trypsin-like serine protease that catalyzes the conversion of prothrombin to thrombin, is located at the crucial intersection of the intrinsic and extrinsic pathways. As a result, it plays a crucial role in the final common pathway of the cascade and has emerged as a key target in the research and development of new anticoagulants. A vital protease in the coagulation process called factor Xa is known to have some of its activity controlled by its interactions with sodium ions and factor Va.
Fibrin, the substance that forms the basis of all blood clots, is produced as a result of an intricate series of enzymatic reactions during blood coagulation. The intrinsic and extrinsic pathways, which make up this cascade's two arms, come together at factor Xa to form the common pathway. Prothrombin is activated by factor Xa to become thrombin, which then catalyzes the transformation of fibrinogen into fibrin.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V128009 | AB054 | AB054 is a humanized monoclonal antibody that targets coagulation factor XII (FXII). | |
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V128789 | Amrecibart | 3008610-20-3 | Amrecibart is a human IgG4κ monoclonal antibody against coagulation factor 11. |
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V129361 | ARC19499 | 1350667-54-7 | ARC19499 is an aptamer that inhibits tissue factor pathway inhibitors (TFPIs), thereby promoting the initiation and propagation of the extrinsic coagulation pathway. |
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V129362 | ARC19499 sodium | ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitors (TFPIs), thereby promoting the initiation and propagation of the extrinsic coagulation pathway. | |
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V129363 | ARC19499 sodium scrambled negative control | The ARC19499 sodium scrambled negative control is a negative control with the sequence of ARC19499 sodium salt scrambled. | |
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V114460 | Asundexian-d3 | 2975248-62-3 | Asundexian-d3 (BAY-2433334-d3) is a deuterated derivative of Asundexian. |
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V129860 | Bacithrocin D | 96440-64-1 | Bacitracin D (thiostatin D) can inhibit a variety of proteases and prolong clotting time. |
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V129911 | BAY 3389934 | 2915316-40-2 | BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and 0.66 nM for factor Xa. |
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V116212 | BMS-269223 | 288077-60-1 | BMS-269223 is a potent, selective, and orally effective factor Xa inhibitor (IC50 value of 6.5 nM, EC2xPT value of 32 μM). |
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V3489 | BMS-654457 | 1004551-41-0 | BMS-654457 is a novel, potent, reversible small-molecule inhibitor of factor XIa (FXIa), which binds to human and rabbit FXIa withKis of 0.2 and 0.42 nM, respectively. |
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V73150 | Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) | 65147-06-0 | Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activating factor X (FXa)-specific fluorescent peptide substrate for the determination of factor VIII. |
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V130539 | Bovine Factor X | 9001-29-0 | Bovine Factor X is a bovine coagulation factor. |
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V118637 | Bz-Pro-Phe-Arg-pNA hydrochloride | 59188-28-2 | Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) hydrochloride is a chromogenic peptide substrate that can be used for the detection of plasma and glandular kallikrein, cysteine proteases, and trypsin. |
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V73146 | CH3OCO-D-CHA-Gly-Arg-pNA acetate | 80895-10-9 | CH3OCO-D-CHA-Gly-Arg-pNA acetate is the chromogenic substrate of factor Xa. |
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V87433 | Ciraparantag acetate | 1644388-83-9 | Ciraparantag (PER977) acetate is a thrombin and Factor Xa inhibitor. |
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V94919 | Ciraparantag TFA | 1438492-27-3 | Ciraparantag TFA is a thrombin and factor Xa inhibitor. |
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V106304 | cMCoFx1 | 2853605-24-8 | cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. |
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V79166 | D-Leu-Pro-Arg-Rh110-D-Pro | D-Leu-Pro-Arg-Rh110-D-Pro is a substrate of Factor Xa I (FXIa) with binding affinity. | |
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V85969 | D-Leu-Pro-Arg-Rh110-D-Pro acetate | ||
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V79167 | D-Leu-Pro-Arg-Rh110-D-Pro TFA | D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate of Factor Xa I (FXIa) with binding affinity. |
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