Factor Xa

Factor Xa

Factor Xa, a trypsin-like serine protease that catalyzes the conversion of prothrombin to thrombin, is located at the crucial intersection of the intrinsic and extrinsic pathways. As a result, it plays a crucial role in the final common pathway of the cascade and has emerged as a key target in the research and development of new anticoagulants. A vital protease in the coagulation process called factor Xa is known to have some of its activity controlled by its interactions with sodium ions and factor Va.

Fibrin, the substance that forms the basis of all blood clots, is produced as a result of an intricate series of enzymatic reactions during blood coagulation. The intrinsic and extrinsic pathways, which make up this cascade's two arms, come together at factor Xa to form the common pathway. Prothrombin is activated by factor Xa to become thrombin, which then catalyzes the transformation of fibrinogen into fibrin.

Factor Xa related products

Structure Cat No. Product Name CAS No. Product Description
Abelacimab (MAA868) V73138 Abelacimab (MAA868) 2098724-83-3 Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody (mAb) that binds with high affinity to the catalytic domain of FXI and locks it in a zymogen conformation, thereby preventing its activation by FXIIa or thrombin.
Apixaban 13CD3 V40309 Apixaban 13CD3 1261393-15-0 Apixaban 13CD3, the deuterated form of Apixaban, is an internal standard (IS) extensively used for the quantification of apixaban which is a coagulation factor Xa inhibitor used to treat and prevent the formation of blood clots.
ARC19499 (BAX499) V73140 ARC19499 (BAX499) 1350667-54-7 ARC19499 is a nucleic acid aptamer that specifically binds to tissue factor pathway inhibitor (TFPI) and blocks the inhibitory effect of TFPI on factor Xa and TF/factor VIIa complexes.
BETRIXABAN V3917 BETRIXABAN 330942-05-7 Betrixaban (trade name Bevyxxa; formerly PRT054021; MK-4448; PRT-021; MLN-1021 etc.
BMS-654457 V3489 BMS-654457 1004551-41-0 BMS-654457 is a novel, potent, reversible small-molecule inhibitor of factor XIa (FXIa), which binds to human and rabbit FXIa withKis of 0.2 and 0.42 nM, respectively.
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) V73150 Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) 65147-06-0 Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activating factor X (FXa)-specific fluorescent peptide substrate for the determination of factor VIII.
CH3OCO-D-CHA-Gly-Arg-pNA acetate V73146 CH3OCO-D-CHA-Gly-Arg-pNA acetate 80895-10-9 CH3OCO-D-CHA-Gly-Arg-pNA acetate is the chromogenic substrate of factor Xa.
D-Leu-Pro-Arg-Rh110-D-Pro V79166 D-Leu-Pro-Arg-Rh110-D-Pro D-Leu-Pro-Arg-Rh110-D-Pro is a substrate of Factor Xa I (FXIa) with binding affinity.
D-Leu-Pro-Arg-Rh110-D-Pro acetate V85969 D-Leu-Pro-Arg-Rh110-D-Pro acetate
D-Leu-Pro-Arg-Rh110-D-Pro TFA V79167 D-Leu-Pro-Arg-Rh110-D-Pro TFA D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate of Factor Xa I (FXIa) with binding affinity.
Dechloro Rivaroxaban V73135 Dechloro Rivaroxaban 1415566-28-7 Dechloro Rivaroxaban is an orally bioactive, selective inhibitor of Factor Xa.
Denecimig (Mim8) V73149 Denecimig (Mim8) 2488745-86-2 Denecimig (Mim8) is an activated factor VIII mimetic human bispecific antibody with anti-FIXa and anti-FX arms that effectively stimulates FX activation, resulting in effective hemostasis in vitro and in vivo.
Edoxaban impurity 4 (Edoxaban impurity D) V71918 Edoxaban impurity 4 (Edoxaban impurity D) 480452-36-6 Edoxaban impurity 4 is an impurity in Edoxaban.
Edoxaban tosylate (DU-176b) V30461 Edoxaban tosylate (DU-176b) 480449-71-6 Edoxaban tosylate (DU176b;DU-176; trade name Savaysa; Lixiana), the tosylate salt of edoxaban, is a marketed anticoagulant drug acting as a potent, selective, orally bioavailable anddirect factor Xa inhibitor.
EMD 495235 V73143 EMD 495235 811811-33-3 EMD 495235 is a potent orally bioactive coagulation factor Xa (factor Xa) inhibitor (antagonist) with IC50 of 5.5 nM and a Ki of 6.8 nM.
Frunexian (EP-7041) V73148 Frunexian (EP-7041) 1803270-60-1 Frunexian (EP-7041) is a selective factor XI/activated factor XI inhibitor targeting Factor XIa.
FXa-IN-1 V73141 FXa-IN-1 441328-10-5 FXa-IN-1 is an FXa inhibitor (IC50= 3 nM, Ki: 0.7 nM) with considerable oral bioavailability (F) and half-life (in vivo).
FXIa-IN-13 V73144 FXIa-IN-13 2629361-99-3 FXIa-IN-13 (example 1) is a Factor Xa inhibitor (antagonist) with antithrombotic activity.
FXIa-IN-14 V84089 FXIa-IN-14 2423992-72-5
FXIa-IN-6 V73151 FXIa-IN-6 1551459-37-0 FXIa-IN-6 is a potent inhibitor of FXIa, selective for most related serine proteases (Ki = 0.3 nM).
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