Maternal embryonic leucine zipper kinase, or MELK, is a member of the CAMK superfamily of serine/threonine protein kinases. A protein serine/threonine kinase called Melk is most active during the mitotic process. It participates in a number of processes, including the cell cycle, cytokinesis, mRNA splicing, and apoptosis. Expression Cells from various tissue origins express MELK.The cell cycle has a significant impact on MELK expression because cells that have completed the cell cycle do not express MELK. Although MELK's precise role is currently unknown, it has been demonstrated that it plays a role in cytokinesis, apoptosis, and the Bcl-2 family of proapoptotic genes as well as apoptosis signal-regulating kinase (ASK1) and the inhibition of mRNA splicing during mitosis as a result of its association with NIPP1. In vivo mammary tumorigenesis requires MELK function.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78074 | Antitumor agent-116 | Antitumor agent-116 (compound 6C) is an antitumor agent with antiproliferation activity. | |
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V2913 | MELK-8a | 1922153-17-0 | MELK-8a is a novel, highly potent and selective MELK (Maternal Embryonic Leucine Zipper Kinase) inhibitor. |
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V3705 | MELK-8a HCl | 2096992-20-8 | MELK-8a HCl is a novel, highly potent and selective MELK (Maternal Embryonic Leucine Zipper Kinase) inhibitor. |
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V1961 | OTSSP167 (OTS167) | 1431697-89-0 | OTSSP167 (OTSSP-167; OTS167; OTS-167)is a highly potent,orally bioavailable inhibitor of MELK (maternal embryonic leucine zipper kinase) with anticancer activity. |
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V3832 | OTSSP167 HCl (OTS167) | 1431698-10-0 | OTSSP167 HCl (OTS167 HCl), the hydrochloride salt of OTSSP-167 (OTS-167), is an orally bioavailable inhibitor of MELK (maternal embryonic leucine zipper kinase) with IC50 of 0.41 nM. |
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