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Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.

A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.

DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.

Dipeptidyl Peptidase related products

Structure Cat No. Product Name CAS No. Product Description
(–)-Sitagliptin carbamoyl glucuronide V107892 (–)-Sitagliptin carbamoyl glucuronide 940002-59-5 (–)-Sitagliptin carbamoyl glucuronide is a secondary metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin.
(Rac)-Regaloside D V122036 (Rac)-Regaloside D 1935714-45-6 (Rac)-Regaloside D is a phenylpropanoid compound.
2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one V73083 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one 1809980-25-3 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a naturally occurring compound found in the bark of M.
5-Hydroxy saxagliptin hydrochloride V127027 5-Hydroxy saxagliptin hydrochloride 5-Hydroxy saxagliptin hydrochloride is the active metabolite of saxagliptin and is a potent and selective DPP-4 inhibitor.
Acetyl-L-Ieucyl-L-argininal V128131 Acetyl-L-Ieucyl-L-argininal 35039-75-9 Acetyl-L-leucyl-L-arginine aldehyde can inhibit the activity of peptidyl aminopeptidase III.
Antidiabetic agent 2 V77995 Antidiabetic agent 2 Antidiabetic agent 2 (Compound 56) is a glucose uptake enhancer.
AX8819 V129698 AX8819 928161-33-5 AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC50 of 0.88 nM.
Azaleatin V73071 Azaleatin 529-51-1 Azaleatin is an O-methylated flavonol extracted from Rhododendron species.
AZD5248 V84722 AZD5248 1254318-44-9
Brensocatib (AZD7986) V3984 Brensocatib (AZD7986) 1802148-05-5 Brensocatib (formerly known asAZD-7986; INS-1007) is anovel, second generation, highly potent, covalent reversible, and selective DPP1 (Dipeptidyl peptidase 1) inhibitor with anti-COPD effects.
Cetagliptin V105147 Cetagliptin 2243737-33-7 Sitagliptin is an orally active dipeptidyl peptidase 4 (DPP-4) and CYP2D6 inhibitor (IC50 of 6 µM).
DPP IV/hCA II-IN-1 V73079 DPP IV/hCA II-IN-1 2836996-95-1 DPP IV/hCA II-IN-1 is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA).
DPP-4-IN-10 V87379 DPP-4-IN-10 1123219-12-4 DPP-4-IN-10 (compound 1) is a DPP-4 inhibitor.
DPP-4-IN-11 V99633 DPP-4-IN-11 DPP-4-IN-11 (Compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity.
DPP-4-IN-12 V97155 DPP-4-IN-12 DPP-4-IN-12 (Compound 46) is a potent DPP-4 inhibitor with IC50 of 2 nM.
DPP-4-IN-13 V104404 DPP-4-IN-13 DPP-4-IN-13 (Compound 9i) is a competitive DPP4 inhibitor with IC50 of 9.25 μM, which can be used in the study of type 2 diabetes.
DPP-4-IN-14 V105206 DPP-4-IN-14 DPP-4-IN-14 (Compound 30) is a DPP-4 inhibitor with IC50 of 12.82 nM.
DPP-4-IN-15 V134306 DPP-4-IN-15 3035300-36-5 DPP-4-IN-15 is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 of 8.24 μM.
DPP-4-IN-16 V134307 DPP-4-IN-16 DPP-4-IN-16 is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor (IC50 = 0.8 nM).
DPP-4-IN-9 V84277 DPP-4-IN-9 2906243-39-6
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