Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.

A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.

DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.

Dipeptidyl Peptidase related products

Structure Cat No. Product Name CAS No. Product Description
V73083 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one 1809980-25-3 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a naturally occurring compound found in the bark of M.
V77995 Antidiabetic agent 2 Antidiabetic agent 2 (Compound 56) is a glucose uptake enhancer.
V73071 Azaleatin 529-51-1 Azaleatin is an O-methylated flavonol extracted from Rhododendron species.
V84722 AZD5248 1254318-44-9
V51751 Begelomab (SAND-26) 1403744-56-8 Begelomab (SAND-26) is a mouse IgG2b monoclonal antibody (mAb) directed against DPP-4/CD26.
V3984 Brensocatib (AZD7986) 1802148-05-5 Brensocatib (formerly known asAZD-7986; INS-1007) is anovel, second generation, highly potent, covalent reversible, and selective DPP1 (Dipeptidyl peptidase 1) inhibitor with anti-COPD effects.
V2857 DBPR108 1186426-66-3 DBPR108 is a novel, potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; It shows no inhibition on DDP8 and DPP9.
V73079 DPP IV/hCA II-IN-1 2836996-95-1 DPP IV/hCA II-IN-1 is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA).
V84277 DPP-4-IN-9 2906243-39-6
V73076 DPP1-IN-1 2762114-61-2 DPP1-IN-1 (compound 1) is a potent DPP1 inhibitor.
V73069 DPP1-IN-1 hydrate 2971064-13-6 DPP1-IN-1 hydrate is a DPP1 inhibitor (IC50= 1.6 nM).
V73075 Fotagliptin (SAL067 free base) 1312954-58-7 Fotagliptin is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM).
V73072 Fotagliptin benzoate (SAL067) 1403496-40-1 Fotagliptin benzoate is a dipeptidyl peptidase IV (DPP-4) inhibitor (IC50=2.27 nM).
V73070 Gemigliptin tartrate (LC15-0444 tartrate) 1374639-74-3 Gemigliptin tartrate (LC15-0444 tartrate) is a selective, reversible, competitive dipeptidyl peptidase 4 (DPP-4) inhibitor (antagonist) with IC50 of 10.3 nM for human recombinant DPP-4.
V84286 Gly-Pro-pNA hydrochloride 103213-34-9
V73081 Lys-Ala-pNA 115846-24-7 Lys-Ala-pNA is a hydrolytic substrate for dipeptidyl peptidase (DPP) II with a Km of 0.42 mM.
V73078 NVP-DPP728 dihydrochloride 207556-62-5 NVP-DPP728 di-HCl is a potent and specific inhibitor of dipeptidyl peptidase IV (DPP-IV) with a Ki of 11 nM.
V73077 O-Benzoylhydroxylamine 54495-98-6 O-Benzoyloxyamine is a DPP-IV inhibitor (antagonist) with anti-diabetic effects (WO2006034435A2).
V73080 P32/98 136259-20-6 P32/98 is a dipeptidyl peptidase IV (DPP4) inhibitor.
V73073 Sheng Gelieting (CGT-8012) 1152810-23-5 Sheng Gelieting (CGT-8012) is a dipeptidyl peptidase-IV enzyme (DP-IV) inhibitor.
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