Dipeptidyl Peptidase

Dipeptidyl Peptidase

Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.

A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.

DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.

Dipeptidyl Peptidase related products

Structure Cat No. Product Name CAS No. Product Description
V73083 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one 1809980-25-3
V77995 Antidiabetic agent 2
V73071 Azaleatin 529-51-1
V51751 Begelomab (SAND-26) 1403744-56-8 IgG2b monoclonal antibody against DPP-4/CD26
V3984 Brensocatib (AZD7986) 1802148-05-5 Brensocatib (formerly known asAZD-7986; INS-1007) is anovel, second generation, highly potent, covalent reversible, and selective DPP1 (Dipeptidyl peptidase 1) inhibitor with anti-COPD effects.
V2857 DBPR108 1186426-66-3 DBPR108 is a novel, potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; It shows no inhibition on DDP8 and DPP9.
V73079 DPP IV/hCA II-IN-1 2836996-95-1
V73076 DPP1-IN-1 2762114-61-2
V73069 DPP1-IN-1 hydrate 2971064-13-6
V73075 Fotagliptin (SAL067 free base) 1312954-58-7
V73072 Fotagliptin benzoate (SAL067) 1403496-40-1
V73070 Gemigliptin tartrate (LC15-0444 tartrate) 1374639-74-3
V73081 Lys-Ala-pNA 115846-24-7
V73078 NVP-DPP728 dihydrochloride 207556-62-5
V73077 O-Benzoylhydroxylamine 54495-98-6
V73080 P32/98 136259-20-6
V73073 Sheng Gelieting (CGT-8012) 1152810-23-5
V73074 Sitagliptin fenilalanil hydrochloride 1339954-75-4
V29755 Sitagliptin phosphate 654671-78-0 Sitagliptin phosphate (MK431; Januvia), thephosphate salt ofSitagliptin, is an antihyperglycemic agent (sugar-lowering) and antidiabetic medication that act as a potent inhibitor of DPP-IV (dipeptidyl peptidase-4) with IC50 of 19 nM in Caco-2 cell extracts.
V76456 Talabostat isomer mesylate
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