Raf kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.Rapidly Accelerated Fibrosarcoma is referred to as RAF. The RAS-RAF-MEK-ERK signal transduction cascade, also known as the mitogen-activated protein kinase (MAPK) cascade, involves Raf kinases. Interaction with RAS-GTPases is necessary for RAF kinase activation. A-RAF, B-RAF, and C-RAF (Raf-1) are the three members of the RAF kinase family. The B-Raf protein is involved in transmitting signals within cells that control cell growth.It was demonstrated that it was flawed (mutated) in a few human cancers. The RAF1 gene in humans encodes the enzyme C-RAF, also known as Raf-1. The c-Raf protein is a MAP kinase kinase (MAP3K) that works after the Ras subfamily of membrane-associated GTPases. It is a component of the ERK1/2 pathway. C-Raf is a member of the TKL (Tyrosine-kinase-like) group of protein kinases and belongs to the Raf kinase family of serine/threonine-specific protein kinases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V50935 | (Z)-GW-5074 | 1233748-60-1 | c-Raf inhibitor |
![3-(二甲基氨基)-N-[3-[(4-羟基苯甲酰基)氨基]-4-甲基苯基]苯甲酰胺](http://www.invivochem.com/upload/0201/CgAGS12clYCAHlQTAAAth0_gwj8202.png)
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V1009 | ZM 336372 | 208260-29-1 | ZM 336372 (ZM-336372; ZM336372) is a novel, potent and selective c-Raf kinase inhibitor with potential anticancer activity. |
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V2761 | AD80 | 1384071-99-1 | AD80 is a novel multikinase inhibitor that shows strong activity against human RET, BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. |
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V1013 | Agerafenib (CEP-32496; RXDX-105; AC013773) | 1188910-76-0 | Agerafenib (formerly RXDX105; AC013773;RXDX-105;CEP-32496;AC-01377)is a potent and orally bioactive inhibitor of BRAFV600E and c-Raf with potential antitumor activity. |
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V97930 | Avutometinib potassium | 946128-90-1 | Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that effectively inhibits RAF/MEK kinase activity, induces RAF-MEK negative complex, and blocks phosphorylation of MEK by ARAF, BRAF, and CRAF. |
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V1006 | AZ 628 (AZ-628; AZ628) | 878739-06-1 | AZ-628 (AZ628; AZ 628) is a novel, selective, and orally bioavailable Raf inhibitor with potential antineoplastic activity. |
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V74131 | B-Raf IN 13 | 2573782-74-6 | B-Raf IN 13 is a BRAF inhibitor (antagonist) with IC50 of 3.55 nM in the BRAF V600E enzyme assay. |
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V74141 | B-Raf IN 14 | 326918-98-3 | B-Raf IN 14 (Comp 25) is a BRAF inhibitor (antagonist) with IC50 of 11.08 μM and may be utilized in cancer-related research. |
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V74147 | B-Raf IN 16 | 2304746-24-3 | B-Raf IN 16 (Compound I) is a BRAF inhibitor belonging to the cyclic iminopyrimidine analogues. |
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V74133 | B-Raf IN 2 | 2649372-20-1 | B-Raf IN 2 is a potent and specific BRAF inhibitor for cancer-related research. |
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V3442 | B-Raf inhibitor 1 | 1093100-40-3 | B-Raf inhibitor 1 is a novel, potent and selectiveRafkinase inhibitor withKis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. |
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V110832 | B-Raf-IN-20 | B-Raf IN 20 (compound Z-001) is a novel B-RAF inhibitor with an IC50 value of 37.80 nM. | |
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V74139 | Belvarafenib TFA (HM95573 TFA; GDC-5573 TFA; RG6185 TFA) | 2443966-84-3 | Belvarafenib TFA (HM95573 TFA) is a potent, broad inhibitor of rapidly accelerating fibrosarcoma kinase (RAF) with IC50s of 56 nM, 7 nM and C-RAF for B-RAF, B-RAFv600E and C-RAF, respectively. |
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V4710 | BI-882370 | 1392429-79-6 | BI-882370 (BI 882370), structurally similar to vermurafenib, is a novel, highly potent and selective BRAF inhibitor with anticancer activity. |
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V119495 | BRAF ligand-1 | 2413037-31-5 | BRAF ligand-1 is a ligand of BRAF. |
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V117616 | BRAF V600E Recombinant Human Active Protein Kinase | BRAF is a member of the Raf kinase family, which belongs to the growth signal transduction protein kinase family. | |
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V87104 | Braftide | 2411851-64-2 | Braftide is an allosteric inhibitor of BRAF kinase that inhibits the formation of BRAF dimers by targeting the surface of BRAF kinase dimers. |
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V94072 | BRAFV600E-IN-1 | BRAFV600E-IN-1 (Compound 9S) is a BRAF inhibitor. | |
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V118663 | BRAFV600E-IN-2 | 3027070-47-6 | BRAFV600E-IN-2 (compound 10) is a BRAFV600E inhibitor with an IC50 <10 nM. |
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V116023 | BRAFV600E-IN-3 | BRAFV600E-IN-3 (compound AV05) is a BRAFV600E inhibitor with an IC50 value of 0.89 μM. |
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