yingweiwo

Eukaryotic Initiation Factor

Eukaryotic Initiation Factor

Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation.These proteins offer regulatory mechanisms for translation initiation as well as aid in stabilizing the formation of the functional ribosome around the start codon.

A guanine nucleotide-exchange protein called eukaryotic initiation factor 2B (eIF2B) facilitates the conversion of GDP (bound to eIF2) into GTP, thereby regenerating the active [eIF2.GTP] complex necessary for peptide chain initiation. An important regulator of eukaryotic protein synthesis, eIF2B activity changes in response to viral infection, hormones, nutrients, growth factors, and specific stresses.

The role of eukaryotic translation initiation factor 4E (eIF4E) in the beginning of protein synthesis on capped mRNAs in the cytoplasm is well known. The initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome, is composed of the eukaryotic initiation factor (elF) 4A as a subunit.

Eukaryotic Initiation Factor related products

No Data!
Contact Us