Eukaryotic initiation factors (eIFs) are proteins involved in the initiation phase of eukaryotic translation.These proteins offer regulatory mechanisms for translation initiation as well as aid in stabilizing the formation of the functional ribosome around the start codon.
A guanine nucleotide-exchange protein called eukaryotic initiation factor 2B (eIF2B) facilitates the conversion of GDP (bound to eIF2) into GTP, thereby regenerating the active [eIF2.GTP] complex necessary for peptide chain initiation. An important regulator of eukaryotic protein synthesis, eIF2B activity changes in response to viral infection, hormones, nutrients, growth factors, and specific stresses.
The role of eukaryotic translation initiation factor 4E (eIF4E) in the beginning of protein synthesis on capped mRNAs in the cytoplasm is well known. The initiation factor complex elF4F, which mediates the binding of mRNA to the ribosome, is composed of the eukaryotic initiation factor (elF) 4A as a subunit.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52830 | (Z)-4EGI-1 | 901787-88-0 | (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor (blocker/antagonist) of eIF4E/eIF4G interaction and translation initiation. |
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V11588 | 2BAct | 2143542-28-1 | 2BAct is a novel, potent,highly selective, CNS-permeable, and orally bioactive eif2b (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM, it prevents neurological defects caused by a chronic integrated stress response (ISR). |
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V1946 | 4E1RCat | 328998-25-0 | 4E1RCat is a potent and dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 protein-protein interaction, and also inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM. |
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V1959 | 4EGI-1 | 315706-13-9 | 4EGI-1 is a potent and competitive eIF4E/eIF4G interaction inhibitor which binds to eIF4E with KD of 25 μM. |
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V2815 | Briciclib (ON-014185) | 865783-99-9 | Briciclib (also known as ON 013105; ON 014185) is an orally bioavailable small molecule and a disodium phosphate ester prodrug of ON 013100 with improved water solubility compared to ON 013100. |
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V55219 | CMLD012072 | 2368900-33-6 | CMLD012072 is an amidino-rocaglates and a potent inhibitor of eukaryotic initiation factor 4A (eIF4A). |
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V18324 | CMLD012073 | 2368900-32-5 | CMLD012073 is an amidino-rocaglates and a potent inhibitor of eukaryotic initiation factor 4A (eIF4A). |
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V52239 | CMLD012612 | 2368900-35-8 | CMLD012612 is an amidino-rocaglate containing a hydroxamate group and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. |
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V37649 | Didesmethylrocaglamide | 177262-30-5 | Didesmethylrocaglamide is a naturally occurring rocaglamide type of 1H-cyclopenta[b]benzofuran lignans isolated from three Aglaia species (Aglaia duperreana, A. oligophylla and A. spectabilis). |
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V55207 | DNL343 | 2278265-85-1 | DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that can inhibit the abnormal integrated stress response (ISR). |
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V55214 | eIF4A3-IN-10 | 1402931-72-9 | eIF4A3-IN-10 (compound 58) is an analogue of silvestrol. |
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V55217 | eIF4A3-IN-11 | 1402931-70-7 | eIF4A3-IN-11 (compound 56) is an analogue of silvestrol. |
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V55210 | eIF4A3-IN-12 | 1402931-76-3 | eIF4A3-IN-12 (compound 62) is an analogue of silvestrol. |
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V55216 | eIF4A3-IN-13 | 1402931-85-4 | eIF4A3-IN-13 (compound 75) is an analogue of silvestrol. |
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V55218 | eIF4A3-IN-14 | 1402931-65-0 | eIF4A3-IN-14 (compound 51) is an analogue of silvestrol. |
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V55215 | eIF4A3-IN-15 | 1402931-66-1 | eIF4A3-IN-15 (compound 52) is an analog of silvestrol. |
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V55208 | eIF4A3-IN-16 | 1402931-74-1 | eIF4A3-IN-16 (compound 60) is an analog of silvestrol. |
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V55211 | eIF4A3-IN-17 | 1402931-75-2 | eIF4A3-IN-17 (compound 61) is an analogue of silvestrol. |
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V55209 | eIF4A3-IN-18 | 1402931-84-3 | eIF4A3-IN-18 (compound 72) is an analogue of silvestrol. |
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V55220 | eIF4A3-IN-4 | 2861994-92-3 | eIF4A3-IN-4 is a novel eIF4A inhibitor (antagonist) with IC50 of 8.6 μM. |
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