Opioid Receptor

Opioid Receptor

Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances. Opioid receptors prevent impulses from traveling along excitatory pathways in the human body.The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.

Opioid Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V1279 (+)-Matrine (Vegard) 519-02-8 Matrine (Vegard; α-Matrine; Matridin-15-one; NSC-146051; NSC146051; (+)-Matrine) is a naturally occuring alkaloid found in plants from the Sophora family.
V69970 (+)-N-Allylnormetazocine hydrochloride ((+)-SKF 10047 hydrochloride; (+)-N-Allyl-N-normetazocine hydrochloride) 133005-41-1 (+)-N-Allylnormetazocine ((+)-SKF 10047) HCl is a benzoma opioid compound with psychotropic properties.
V69941 (+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) 67198-17-8 (+)-U-50488 ((+)-Trans-(1R,2R)-U-50488) is an enantiomer of (-)-Trans-(1S,2S)-U-50488.
V69931 (+)-U-50488 hydrochloride ((+)-Trans-(1R,2R)-U-50488 hydrochloride) 114528-81-3 (+)-U-50488 (HCl) (+)-Trans-(1R,2R)-U-50488 HCl) is a κ opioid receptor agonist (activator) with lower activity than (-) trans Enantiomeric (-)-Trans-(1S,2S)-U-50488.
V69890 (-)-U-50488 hydrochloride ((-)-Trans-(1S,2S)-U-50488 hydrochloride) 114528-79-9 (-)-U-50488 HCl ((-)-Trans-(1S,2S)-U-50488 HCl) is a selective kappa-opioid receptor (KOR) agonist (Kd=2.2 nM) with greater selectivity than μ opioid receptor (MOR) (Kd=430 nM).
V69886 (1R,2R)-U-50488 hydrochloride 109620-49-7 (1R,2R)-U-50488 HCl is the absolute configuration of (±)-U-50488 HCl.
V69932 (D-Met2,Pro5)-Enkephalinamide 63307-63-1 (D-Met2,Pro5)-Enkephalinamide is a potent opioid agonist with antinociceptive activity.
V2524 (R)-(-)-GR103545 fumarate 126766-43-6 GR103545 is a potent and specific kappa-opioid receptor (κ-OR) agonist.
V69922 (Rac)-SNC80 ((Rac)-NIH 10815) 1217643-87-2 (Rac)-SNC80 is the racemate of SNC80.
V69902 (S,S)-J-113397 256640-46-7 (S,S)-J-113397 is an enantiomer of J-113397.
V77396 (±)-U-50488 hydrate hydrochloride ((±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride) (±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate HCl is a κ opioid receptor agonist.
V69892 5'-Guanidinonaltrindole hydrochloride (5'-GNTI hydrochloride) 351183-88-5 5'-Guanidinonaltrindole (5'-GNTI) HCl is a selective κ-opioid receptor antagonist (inhibitor) with a Ki of 0.18 nM for the human κ-opioid receptor.
V69928 6'-GNTI dihydrochloride 2410327-94-3 6'-GNTI di-HCl, a kappa-opioid receptor (KOR) agonist, displays a bias toward G protein-mediated signaling activation during β-arrestin2 recruitment.
V84094 6-Hydroxyflavanone (6-Hydroxyflavanone, 98+%) 4250-77-5
V69933 7-Hydroxymitragynine 174418-82-7 7-Hydroxymitragynine, the bioactive metabolite of Mitragynin, is a potent G protein-biased μ-opioid receptor partial agonist/activator with EC50 of 34.5 nM.
V69917 [(pF)Phe4]Nociceptin(1-13)NH2 380620-88-2 [(pF)Phe4]Nociceptin(1-13)NH2 is a highly efficient and selective NOP receptor (OP4) agonist/activator with pKi of 10.68 and pEC50 of 9.31.
V77464 [(pF)Phe4]Nociceptin(1-13)NH2 TFA [(p-Fluoro)Phe4]Nociceptin-(1-13)NH2 TFA is a highly efficient and selective NOP receptor (OP4) receptor agonist/activator with pKi of 10.68 and pEC50 of 9.31.
V69912 [Arg14,Lys15]Nociceptin 236098-40-1 [Arg14,Lys15]Nociceptin is a potent and specific NOP (ORL1; OP4) receptor agonist/activator with EC50 of 1 nM.
V77471 [Arg14,Lys15]Nociceptin TFA [Arg14,Lys15]Nociceptin TFA is a potent and specific NOP (ORL1; OP4) receptor agonist/activator with EC50 of 1 nM.
V69907 [D-Ala2]-Met-Enkephalinamide 61090-95-7 [D-Ala2]-Met-Enkephalinamide is an opioid peptide and a potent opioid agonist.
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