Deubiquitinases (DUBs) are a family of proteases whose function is to cleave ubiquitin (Ub) or ubiquitin-like proteins from proproteins or ubiquitin(s) conjugated with target substrate.According to their enzymatic cleavage method, DUBs can be classified into two primary classes: zinc metalloproteases and cysteine proteases. These include Jab1/Mov34/Mpr1 (JAMM) metalloproteases, ovarian tumor proteases, Machado-Joseph disease proteases, ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), and novel DUB family, (MINDY) proteases that contain MIU.
A significant post-translational alteration known as ubiquitination is essential for several crucial biological processes. A coordinated action of the E1, E2, and E3 enzymes results in the attachment of ubiquitin to a substrate protein in this process, and DUBs remove it. DUBs are crucial Ub system regulators because they control a wide range of cellular functions, such as protein sorting, trafficking, and turnover. Alterations in DUB activity have been linked to a wide range of diseases, including cancer. DUBs are fresh options for the creation of drugs that are target-directed.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V40649 | (R)-FT671 | 1959551-27-9 | (R)-FT671 is the R-enantiomer of FT671. |
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V52470 | 8RK59 | 2705841-53-6 | 8RK59 is a Bodipy probe and a potent inhibitor of UCHL1 (ubiquitin C-terminal hydrolase L1) with IC50 close to 1 μM. |
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V54451 | 8RK64 | 2705841-52-5 | 8RK64 is a covalent UCHL1 inhibitor. |
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V51254 | BAY-728 | BAY-728 can be used as a negative control (NC) for BAY-805. | |
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V51035 | BAY-805 | 2925481-88-3 | USP21 inhibitor |
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V51249 | BAY-805 | 2925481-88-3 | ubiquitin-specific protease USP21 inhibitor |
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V51256 | CMPD-39 (USP30 inhibitor 18) | 2242582-40-5 | is a selective USP30 inhibitor |
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V54453 | CT1113 | 2523435-18-7 | CT1113 is a potent USP28 and USP25 inhibitor. |
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V54454 | DUB-IN-7 | 2894064-79-8 | DUB-IN-7 (compound 43) is an inhibitor (blocker/antagonist) of deubiquitinating enzymes (DUBs). |
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V51250 | FT-3967385 | USP30 inhibitor | |
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V21381 | FT-671 | 1959551-26-8 | FT671 is a novel, potent,high affinity and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM. |
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V54455 | FT206 | 2278274-34-1 | FT206 is a carboxamides as ubiquitin-specific protrase inhibitor, disclosed in patent WO 2020033707 A1, Example 11-1. |
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V76981 | GK13S | G13KS is a ligand and inhibitor of the deubiquitinase UCHL1. | |
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V76980 | GK16S | GK16S is a UCHL1 chemical genomic probe. | |
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V3858 | GNE-6640 | 2009273-67-8 | GNE-6640, an analog of GNE-6776, is a novel potent and selective inhibitor of USP7 (ubiquitin-specific protease-7). |
|
V3859 | GNE-6776 HCl | 2009273-60-1 | GNE-6776 HCl (GNE6776), the hydrochloride salt of GNE-6776 which is an analog of GNE-6640, is a novel potent and selective inhibitor of USP7 (ubiquitin-specific protease-7) with potential anticancer activity. |
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V75784 | GSK2643943A | 2449301-27-1 | GSK2643943A is a deubiquitinating enzyme (DUB) inhibitor targeting USP20. |
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V51252 | I-138 | 2098211-50-6 | I-138 is a substance that can be consumed and is structurally similar to ML323 . |
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V54456 | IMP-1710 | 2383117-96-0 | IMP-1710 is a potent and specific inhibitor of the deubiquitinating enzyme UCHL1 with IC50 of 38 nM. |
|
V51255 | IU1-248 | 2307472-03-1 | IU1-248 is an analogue of IU1 and a potent and specific USP14 inhibitor (antagonist) with IC50 of 0.83 μM. |
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