Stearoyl-CoA desaturase (SCD) is a key regulator of membrane fluidity, turns over rapidly, and represents a model for selective degradation of short-lived proteins of the endoplasmic reticulum (ER).A key player in the catalysis of the synthesis of monounsaturated fatty acids, primarily oleate and palmitoleate, is the rate-limiting lipogenic enzyme known as SCD. Each makes a significant contribution to the biological membrane. Several SCD isoforms, including SCD-1 and SCD-5 in humans and SCD-1 and SCD-4 in mice, are present.
Diabetes and non-alcoholic fatty liver disease are two metabolic diseases that exhibit overexpression of SCD. SCD promotes tumorigenesis and stemness by activating the YAP pathway and the canonical Wnt pathway. SCD promotes metabolic reprogramming in cancer, which is at least partially mediated by MUFA-mediated control of AKT, AMPK, and NF-kB. From a biological perspective, excessive SCD1 expression results in a variety of metabolic diseases, such as obesity, insulin resistance, hypertension, hypertriglyceridemia, etc. SCD1 is a pharmacological target in the treatment of metabolic diseases like diabetes, obesity, and others.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V8148 | Aramchol (C20-FABAC) | 246529-22-6 | Aramchol (Arachidyl amido cholanoic acid;C20-FABAC),a conjugate of cholic acid and arachidic acid,is a cholesterol solubilizer that prevents gallstone formation in inbred mice. |
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V2095 | CAY10566 | 944808-88-2 | CAY10566 is a novel,orally bioavailable and selective SCD1 (stearoyl-CoA desaturase 1) inhibitor with IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. |
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V2687 | CVT-12012 | 1018675-35-8 | CVT-12012 (also known as CVT12012, CVT 12012) is anorally bioavailable stearoyl-coA desaturase (SCD) inhibitor (IC50s = 38 nM, 6.1 nM for rat microsomal and human HEPG2). |
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V3616 | GSK1940029 | 1150701-66-8 | GSK1940029 (also known as SCD Inhibitor 1) is a SCD Inhibitor that has the potential as a topical treatment for acne. |
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V4456 | SCD1 inhibitor-3 | 1282606-48-7 | SCD1 inhibitor-3 is a safe, effective orally bioactive SCD1 inhibitor. |
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V2477 | SCD1 inhibitor-4 | 1295541-87-5 | SCD1 inhibitor-4 is a novel, potent, and orally bioactive stearoylCoA desaturase-1 (SCD1) inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo. |
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V72975 | SSI-4 | 1875084-68-6 | SSI-4 is an inhibitor (blocker/antagonist) of stearoyl-CoA desaturase 1 (SCD1) and can be modified with 11C and used as a ligand for SCD1 in vivo small animal PET/CT imaging. |
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V72976 | Sterculic acid | 738-87-4 | Sterculic acid is a stearoyl-CoA desaturase 1 (SCD1) inhibitor. |
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V4457 | YTX-465 | 2225824-53-1 | YTX-465 is an inhibitor (blocker/antagonist) of stearoyl-CoA desaturase (Ole1/SCD). |
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