The nuclear retinoic acid receptors (RARs) are transcriptional transregulators that regulate the phosphorylation and expression of particular gene subsets after ligand binding. RARs are divided into three subtypes, (NR1B1), (NR1B2), and (NR1B3), each of which is encoded by a different gene. RXRs, which also come in three types: NR2B1, NR2B2, and NR2B3, heterodimerize with RARs to function as ligand-dependent transcriptional regulators. RARs are essential for many biological functions, including development, reproduction, immunity, organogenesis, and homeostasis, as demonstrated by studies on vitamin A deficiency (VAD), pharmacological effects, and genetics in mice.
The retinoid X receptor (RXR) is a member of a family of transcription factors that are activated by ligands and control numerous aspects of metazoan life. For some nuclear receptors to work, RXR must be one of the heterodimerization partners.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V7565 | Tarenflurbil | 51543-40-9 | Tarenflurbil [(R)-Flurbiprofen], the R-enantiomer of flurbiprofen,is a novel and potent activator of c-Jun N terminal kinase. |
|
V100617 | AGN 193109 sodium | 2319838-82-7 | AGN 193109 Sodium is the sodium salt form of AGN 193109. |
|
V2820 | AM580 | 102121-60-8 | AM580 (also named CD336, NSC608001, Ro 40-6055) is a stable retinobenzoic analog that is originally synthesized as a novel, potent and selective RARα agonist with IC50and EC50of 8 nM and 0.36 nM, respectively. |
|
V3243 | AR-7 | 80306-38-3 | AR-7 (Atypical Retinoid 7) is a potent and selective retinoic acid receptor α (RARα) antagonist and an enhancer of the chaperone-mediated autophagy (CMA). |
|
V83490 | Arotinoid (Ro 13-6298; Arotinoid ethyl ester) | 71441-09-3 | |
|
V111277 | CU-6PMN | 2099034-38-3 | CU-6PMN is a fluorescent RXR agonist. |
|
V85016 | DC271 | 198696-03-6 | |
|
V104840 | DC360 | 2324152-25-0 | DC360 is a synthetic all-trans retinoic acid (ATRA) analog that induces RARβ expression. |
|
V96702 | Elodeoidileon A | Elodeoidileon A is an agonist of RXRα, and the dissociation constant Kd of its interaction with RXRα-LBD protein is 5.85 μM. | |
|
V77033 | ER 50891 quarterhydrate | ER 50891 quarterhydrate is a potent retinoic acid receptor alpha (RARα) antagonist. | |
|
V110382 | ER-38925 | 196517-43-8 | ER-38925 is a retinol agonist that selectively acts on the α-retinol receptor (RAR-α). |
|
V7843 | HX 531 | 188844-34-0 | HX-531 is a novel and potent antagonist of retinoid X receptors (RXR) with an IC50 value of 18 nM. |
|
V109399 | Hydroxypinacolone retinoate | 893412-73-2 | Hydroxypinazone retinyl ester (HPR) is a retinol derivative that can directly bind to retinoic acid receptors (RARs). |
|
V22666 | IRX5183 (NRX195183, VTP195183, AGN195183) | 367273-07-2 | IRX5183 (NRX-195183, VTP-195183, AGN-195183) is a potent, selective, and orally bioavailable retinoid acid receptor (RAR) alpha agonist with potential antineoplastic activity. |
|
V85256 | JP3000 | 3034097-74-7 | |
|
V118592 | LE-540 | 188645-44-5 | LE-540 is a selective RARβ retinoic acid receptor antagonist (Ki=0.22 μM). |
|
V2132 | LY-2955303 | 1433497-19-8 | LY2955303 (LY-2955303) is a novel, potent and selectiveantagonist of retinoic acid receptor gamma(RARγ) with potential to manage osteoarthritis pain. |
|
V114926 | MDI-403 | 127471-94-7 | MDI-403 is a retinoic acid receptor (RAR) agonist with an EC50 < 1 μM. |
|
V17767 | CD437 | 125316-60-1 | CD437 is a selective retinoic acid receptor γ (RARγ) agonist. |
|
V115977 | R-116010 | 355860-40-1 | R-116010 is a potent and selective retinoic acid (RA) metabolism inhibitor that inhibits the hydroxylase CYP26. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
