The nuclear retinoic acid receptors (RARs) are transcriptional transregulators that regulate the phosphorylation and expression of particular gene subsets after ligand binding. RARs are divided into three subtypes, (NR1B1), (NR1B2), and (NR1B3), each of which is encoded by a different gene. RXRs, which also come in three types: NR2B1, NR2B2, and NR2B3, heterodimerize with RARs to function as ligand-dependent transcriptional regulators. RARs are essential for many biological functions, including development, reproduction, immunity, organogenesis, and homeostasis, as demonstrated by studies on vitamin A deficiency (VAD), pharmacological effects, and genetics in mice.
The retinoid X receptor (RXR) is a member of a family of transcription factors that are activated by ligands and control numerous aspects of metazoan life. For some nuclear receptors to work, RXR must be one of the heterodimerization partners.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2033 | Acitretin (Ro 10-1670) | 55079-83-9 | Acitretin (also known as Etretin, RO 10-1670; Soriatane; Etretin; Neotigason)is a novel, potent, orally bioavailable, second generation retinoid used for psoriasis. |
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V2820 | AM580 | 102121-60-8 | AM580 (also named CD336, NSC608001, Ro 40-6055) is a stable retinobenzoic analog that is originally synthesized as a novel, potent and selective RARα agonist with IC50and EC50of 8 nM and 0.36 nM, respectively. |
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V3243 | AR-7 | 80306-38-3 | AR-7 (Atypical Retinoid 7) is a potent and selective retinoic acid receptor α (RARα) antagonist and an enhancer of the chaperone-mediated autophagy (CMA). |
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V83490 | Arotinoid (Ro 13-6298; Arotinoid ethyl ester) | 71441-09-3 | |
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V17767 | CD437 | 125316-60-1 | CD437 is a selective retinoic acid receptor γ (RARγ) agonist. |
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V85016 | DC271 | 198696-03-6 | |
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V77033 | ER 50891 quarterhydrate | ER 50891 quarterhydrate is a potent retinoic acid receptor alpha (RARα) antagonist. | |
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V7843 | HX 531 | 188844-34-0 | HX-531 is a novel and potent antagonist of retinoid X receptors (RXR) with an IC50 value of 18 nM. |
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V22666 | IRX5183 (NRX195183, VTP195183, AGN195183) | 367273-07-2 | IRX5183 (NRX-195183, VTP-195183, AGN-195183) is a potent, selective, and orally bioavailable retinoid acid receptor (RAR) alpha agonist with potential antineoplastic activity. |
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V85256 | JP3000 | ||
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V2132 | LY-2955303 | 1433497-19-8 | LY2955303 (LY-2955303) is a novel, potent and selectiveantagonist of retinoic acid receptor gamma(RARγ) with potential to manage osteoarthritis pain. |
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V1992 | Magnolol (2,2'-Bichavicol) | 528-43-8 | Magnolol (also called Dehydrodichavicol and 5,5-Diallyl-2,2-biphenyldiol)is a novel, naturally occuring and bioactive lignin isolated from the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. |
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V3434 | Palovarotene | 410528-02-8 | Palovarotene (formerly RO-3300074; R-667) is a novel, potent and highly selective retinoic acid receptor gamma (RAR-γ) agonist that is being investigated as a potential treatment for emphysema. |
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V78741 | RARα antagonist 1 | RARα antagonist 1 (compound 21) is an orally bioactive and selective retinoic acid receptor α (RARα) antagonist (inhibitor) with IC50 of 4.6 nM. | |
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V51363 | Retinoic acid-d6 | 2483831-72-5 | Retinoic Acid-d6 is a vitamin substitute of Retinoic Acid. |
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V87701 | RXR agonist 1 | RXR agonist 1 (Compound 33) is a highly selective RXR agonist with EC50 of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. | |
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V84358 | RXR antagonist 6 | ||
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V7565 | Tarenflurbil | 51543-40-9 | Tarenflurbil [(R)-Flurbiprofen], the R-enantiomer of flurbiprofen,is a novel and potent activator of c-Jun N terminal kinase. |
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V16789 | Trifarotene (CD5789) | 895542-09-3 | Trifarotene (CD5789; trade name Aklief) is a gamma retinoic acid receptor (RAR) agonist under approved in 2019 as a topical cream for the treatment of skin disorders, including acne vulgaris, cutaneous t-cell lymphoma and lamellar ichthyosis. |
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V31665 | WYC-209 | 2131803-90-0 | WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. |
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