yingweiwo
  1. Home
  2. Products
  3. Signaling Pathways
  4. Protein Tyrosine Kinase
  5. PDGFR

PDGFR

PDGFR

Platelet-derived growth factor receptors (PDGFRs) belong to the receptor tyrosine kinase (RTK) family and serve the function of protein tyrosine kinases.PDGFRs are involved in a number of cellular processes, such as proliferation, migration, survival, and the emergence of cancer, and they are activated by binding to their ligand, PDGFs. Vascular endothelial cells, fibroblasts, and Kupffer cells are where PDGFRs are primarily found. The two receptor types, PDGFR- and PDGFR-, share structural similarities and are made up of intracellular kinase domains with distinctive inserts of about 100 amino acid residues that have no homology to kinases and extracellular domains with five immunoglobulin (Ig)-like domains.Direct receptor-receptor interactions involving Ig-like domain 4 stabilize the receptor dimerization, which is primarily caused by ligand binding to Ig-like domains 2 and 3.The juxtaposition of the intracellular components during dimerization, which encourages autophosphorylation in trans between the receptors, is a crucial step in activation. The phosphorylated PDGFR then recruits molecules with SH2 domains like Src kinase, Grb2, SHP2, PLC, Nck, and STAT to start various downstream signaling events.

PDGFR related products

Structure Cat No. Product Name CAS No. Product Description
V119023 PDGFRalpha V561D Recombinant Human Active Protein Kinase PDGFRα is a receptor tyrosine kinase that can stimulate cell survival, proliferation, and migration.
V119673 Vasigrobart 3030730-59-4 Vasigrobart is a humanized antibody expressed in CHO cells that targets PDGFB.
V118823 PDGFRalpha D842V Recombinant Human Active Protein Kinase PDGFRα is a receptor tyrosine kinase that can stimulate cell survival, proliferation, and migration.
V118875 PDGFRalpha T674I Recombinant Human Active Protein Kinase PDGFRα is a receptor tyrosine kinase that can stimulate cell survival, proliferation, and migration.
V119311 PDGFRα kinase-IN-2 3066103-58-7 PDGFRα kinase-IN-2 is a potent PDGFR-α inhibitor with an IC50 value of 2.1 nM.
V111016 Sunitinib glucuronate 1818285-48-1 Sunitinib (SU 11248) glucuronic acid is a multi-target receptor tyrosine kinase inhibitor with an IC50 value of 80 nM for VEGFR2 and 2 nM for PDGFRβ.
V113554 1-Phenylindole 16096-33-6 1-Phenylindole (compound 8) is an analog of 1-phenylbenzimidazole.
V117628 Biotin-PDGFRβ Recombinant Human Active Protein Kinase The PDGF-BB/PDGFRβ signaling pathway plays a crucial role in angiogenesis, mediating the recruitment of pericytes to the vascular system and promoting vascular integrity and function.
2-Methyl-3-phenylquinoxaline V102611 2-Methyl-3-phenylquinoxaline 10130-23-1 2-Methyl-3-phenylquinoxaline (Compound 38) is a potent inhibitor of platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) and has limited inhibitory activity against PDGFR kinase in intact cells (IC50 greater than 100 μM).
AC 710 V2880 AC710 1351522-04-7 AC710 is a potent, orally bioactive, and selectiveinhibitor of PDGFR (platelet-derived growth factor receptor) family kinase withKdvalues of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
AC710 Mesylate V2093 AC710 Mesylate 1351522-05-8 AC710 mesylate, the mesylate salt of AC710, is a potent, orally bioactive, and selectiveinhibitor of PDGFR (platelet-derived growth factor receptor) family kinase withKdvalues of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.
cis-SU4312 V88059 cis-SU4312 90828-16-3 cis-SU4312 ((Z)-SU4312) inhibits PDGFR and FLK-1 with IC50 of 19.4 and 0.8 μM, respectively.
CP 673451 V0577 CP-673451 343787-29-1 CP-673451 (CP673451) is a novel, potent, selective and ATP-competitive inhibitor of PDGFR(α/β) with potential antitumor activity.
E8431 V110396 E8431 2419580-01-9 E8431 is a DCSTAMP antagonist, DCSTAMP being a key fusion protein that coordinates cell fusion during osteoclastogenesis.
Gint4.T aptamer sodium V79582 Gint4.T aptamer sodium Gint4.T aptamer sodium is a nuclease-resistant RNA aptamer-based antagonist targeting platelet-derived growth factor receptor beta (PDGFRβ) (Kd: 9.6 nM).
INVIVO74978 V25190 INVIVO74978 778274-97-8 multikinase inhibitor 1 is a potent multikinase inhibitor.
MK-2461 V0575 MK-2461 917879-39-1 MK-2461 (MK2461) is a novel,potent, ATP-competitive, multi-targeted inhibitor for c-Met (WT/mutants) with potential antineoplastic activity.
N-(p-Coumaroyl) Serotonin V69534 N-(p-Coumaroyl) Serotonin 68573-24-0 N-(p-Coumaroyl) Serotonin is a polyphenol extracted from safflower seeds that displays antioxidant, antiatherogenic, and anti-inflammatory activities.
PDGF Receptor Tyrosine Kinase Inhibitor III V13080 PDGF Receptor Tyrosine Kinase Inhibitor III 205254-94-0 PDGF Receptor Tyrosine Kinase Inhibitor III (also known as PDGFR Tyrosine Kinase Inhibitor III) is a novel and potent PDGFR inhibitor.
PDGFRα/β/VEGFR-2-IN-1 V88058 PDGFRα/β/VEGFR-2-IN-1 PDGFRα/β/VEGFR-2-IN-1 (6f) is a multiple PDGFRα/β and VEGFR-2 tyrosine kinase inhibitor that specifically targets PDGFRα, PDGFRβ, and VEGFR-2 kinases at nanomolar concentrations.
Contact Us
Tel: 1-708-310-1919 Fax: 1-708-557-7486 Email: sales@invivochem.com Frequently Asked Questions
Subscribe to our E-newsletter
Name
E-mail

Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved

linkedin facebook
Contact Us
Home Product Cart Member