Epoxide Hydrolase

Epoxide Hydrolase

Epoxide hydrolases (EH) are a component of every living thing. A 120 kDa dimer of two identical, 62.5 kDa monomers arranged in an anti-parallel manner makes up the mammalian soluble epoxide hydrolase (sEH). The liver, kidneys, brain, endothelium, and to a lesser extent other tissues, express it most prominently. Many disease states have significant components of inflammation and pain. Blood pressure, inflammation, and pain are all decreased by mammalian sEH inhibition. The down-regulation of COX2 transcription caused by NF-B, which results in less production of pro-inflammatory prostaglandins like PGE2 and PGD2, is a contributing factor in the anti-inflammatory activities of sEH inhibitors.

Epoxide Hydrolase related products

Structure Cat No. Product Name CAS No. Product Description
V51413 (Rac)-EC5026 ((Rac)-BPN-19186) 1809885-55-9 soluble epoxide hydrolase (sEH)-P inhibitor
V11535 AR-9281 913548-29-5 AR-9281 is a novel and potent inhibitor of soluble epoxide hydrolase (s-EH) that can be potentially used for the treatment of hypertension and type 2 diabetes.
V37609 EC-5026 (BPN-19186) 1809885-32-2 EC5026 (BPN19186) is a novel, first-in-class, potent and orally bioabailable inhibitor of soluble Epoxide Hydrolase (sEH).
V2720 GSK2256294A 1142090-23-0 GSK2256294A (also known as GSK-2256294) is a novel, potent, selective inhibitor of recombinant human, rat and mouse sEH (Soluble epoxide hydrolase) (IC50 = 27 pM) with the potential to be used for endothelial dysfunction or abnormal tissue repair, such as diabetes, wound healing or COPD.
V51410 sEH inhibitor-1 1208549-68-1 soluble epoxide hydrolase (sEH) inhibitor
V79455 sEH inhibitor-10
V79775 sEH inhibitor-11
V79776 sEH inhibitor-12
V79454 sEH inhibitor-13
V78351 sEH inhibitor-16
V74005 sEH inhibitor-2 2816102-69-7
V74006 sEH inhibitor-4 2851838-08-7
V51409 sEH inhibitor-7 340221-20-7 soluble epoxide hydrolase (sEH) inhibitor
V51411 SWE-101 2376322-12-0 soluble epoxide hydrolase (sEH)-P inhibitor
V33532 TPPU 1222780-33-7 TTPU is a soluble epoxide hydrolase (sEH) inhibitor with IC50 of 37 and 3.7 nM for monkey and human sEH, respectively.
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