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Epoxide Hydrolase

Epoxide Hydrolase

Epoxide hydrolases (EH) are a component of every living thing. A 120 kDa dimer of two identical, 62.5 kDa monomers arranged in an anti-parallel manner makes up the mammalian soluble epoxide hydrolase (sEH). The liver, kidneys, brain, endothelium, and to a lesser extent other tissues, express it most prominently. Many disease states have significant components of inflammation and pain. Blood pressure, inflammation, and pain are all decreased by mammalian sEH inhibition. The down-regulation of COX2 transcription caused by NF-B, which results in less production of pro-inflammatory prostaglandins like PGE2 and PGD2, is a contributing factor in the anti-inflammatory activities of sEH inhibitors.

Epoxide Hydrolase related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-EC5026 ((Rac)-BPN-19186) V51413 (Rac)-EC5026 ((Rac)-BPN-19186) 1809885-55-9 (Rac)-EC5026 ((Rac)-BPN-19186) is an example of a potent soluble epoxy hydrolase (sEH) with a Ki of 0.06 nM.
(±)10(11)-EpDPA V99807 (±)10(11)-EpDPA 895127-65-8 (±)10(11)-EpDPA is a metabolite of docosahexaenoic acid epoxidase and can serve as a substrate for soluble epoxide hydrolase (sEH) with a Km value of 5.1 µM for human sEH.
10,11-EDT V84657 10,11-EDT 2763501-00-2
AR-9281 V11535 AR-9281 913548-29-5 AR-9281 is a novel and potent inhibitor of soluble epoxide hydrolase (s-EH) that can be potentially used for the treatment of hypertension and type 2 diabetes.
DJ-53 V94884 DJ-53 DJ-53 (Compound 68) is an orally active phenylquinoline-based soluble epoxide hydrolase inhibitor.
EC-5026 (BPN-19186) V37609 EC-5026 (BPN-19186) 1809885-32-2 EC5026 (BPN19186) is a novel, first-in-class, potent and orally bioabailable inhibitor of soluble Epoxide Hydrolase (sEH).
Epoxykynin V87415 Epoxykynin 640263-95-2 Epoxykynin is a potent epoxide hydrolase (sEH) inhibitor.
FZQ-21 V84770 FZQ-21
GSK2256294A V2720 GSK2256294A 1142090-23-0 GSK2256294A (also known as GSK-2256294) is a novel, potent, selective inhibitor of recombinant human, rat and mouse sEH (Soluble epoxide hydrolase) (IC50 = 27 pM) with the potential to be used for endothelial dysfunction or abnormal tissue repair, such as diabetes, wound healing or COPD.
LQ-38 V93293 LQ-38 LQ-38 is an orally available soluble epoxide hydrolase (sEH) inhibitor with IC50 of 5.2 nM.
S-NEPC V87416 S-NEPC 147349-28-8 S-NEPC (4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate) is a colorimetric substrate used to measure the activity of epoxide hydrolases.
sEH inhibitor-1 V51410 sEH inhibitor-1 1208549-68-1 sEH Inhibitor-1 (Compound TCPU) is a potent surface-active soluble epoxide hydrolase (sEH) with IC50 of 0.4 and 5.3 nM in human and mouse, respectively.
sEH inhibitor-10 V79455 sEH inhibitor-10 sEH inhibitor-10 (compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC50=0.5 μM).
sEH inhibitor-11 V79775 sEH inhibitor-11 sEH inhibitor-11 (compound 35) is an inhibitor (blocker/antagonist) of sEH with IC50 of 0.3 μM.
sEH inhibitor-12 V79776 sEH inhibitor-12 sEH inhibitor-12 (compound 34) is an inhibitor (blocker/antagonist) of sEH with IC50 of 0.7 μM.
sEH inhibitor-13 V79454 sEH inhibitor-13 sEH inhibitor-13 (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor (antagonist) with IC50 of 0.4 μM.
sEH inhibitor-16 V78351 sEH inhibitor-16 2999636-75-6 sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitor (antagonist) with IC50 of 2 nM.
sEH inhibitor-17 V87414 sEH inhibitor-17 2823295-37-8 sEH inhibitor-17 (compound 4f) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 2.94 nM.
sEH inhibitor-2 V74005 sEH inhibitor-2 2816102-69-7 sEH inhibitor-2 (Compound 5l) is an orally bioactive (predicted % absorption: 71.2-88.4%) soluble epoxide hydrolase (sEH) inhibitor (antagonist) with IC50 of 0.9 nM.
sEH inhibitor-4 V74006 sEH inhibitor-4 2851838-08-7 Intensive structural modifications led to the identification of compound B15 as a potent sEH inhibitor (antagonist) with IC50 of 0.03 ± 0.01 nM, which also contains soluble epoxide hydrolase (sEH) that can reduce inflammation and pain.
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