SHP2

SHP2

A 593 amino acid classical non-receptor protein tyrosine phosphatase (PTP), Src-homology-2-containing protein tyrosine phosphatase 2 (SHP2) is encoded by the PTPN11 gene. SHP2 participates in a number of signaling pathways, including PI3K-AKT, JAK-STAT, RAS-MAPK, and PD-1/PD-L1. Additionally, SHP2 controls mitochondrial homeostasis to negatively regulate the activation of the recombinant NLRP3 (NLR family, pyrin domain containing protein 3) inflammasome. SHP2 has been viewed as a very desirable target for treating human diseases, particularly cancer.

SHP2 related products

Structure Cat No. Product Name CAS No. Product Description
V69746 3-Azetidinemethanol hydrochloride 928038-44-2
V2183 Batoprotafib (TNO-155) 1801765-04-7 TNO155 (TNO-155) is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11; IC50=11 nM) with potential anticancer activity.
V69753 BPDA2 2907659-86-1
V78677 CNBCA
V50955 NAT6-297775 1348433-02-2 SHP2 inhibitor
V3210 NSC-87877 56990-57-9 NSC-87877 (NSC87877) is a novel, potent, cell-permeable small molecule and competitive inhibitor of SHP-1 and SHP-2 PTP (protein tyrosine phosphatase) with anticancer activity.
V51367 NSC-87877 disodium 56932-43-5 SHP-1 and SHP-2 PTP inhibitor
V41014 PF-03622905 1072100-15-2
V41013 PF-04577806 1072100-81-2
V69742 PF-07284892 (ARRY-558) 2498597-94-5
V50901 RMC-0331 2488788-52-7 RMC-0331 is a novel and orally active inhibitor of SOS1.
V5027 RMC-4550 2172651-73-7 RMC-4550 (RMC4550) is a novel, potent, selective and allosteric inhibitor of SHP2 phosphatase with anticancer activity.
V3045 SHP099 1801747-42-1 SHP099 (SHP-099), identified through HTS and structure-based drug design, is a potent, selective, orally bioavailable, and highly efficacious allosteric inhibitor of SHP2 [Src homology-2 domain containing protein tyrosine phosphatase-2] with anticancer and anti-osteoarthritis activity.
V3046 SHP099 HCl 1801747-11-4 SHP099 HCl, the HCl salt of SHP-099, isan orally bioavailable, and allostericSHP2 inhibitor with antitumor and anti-inflammatory effects.
V69762 SHP2-IN-13 2951854-02-5
V69748 SHP2-IN-14 2673400-91-2
V78898 SHP2-IN-16
V69757 SHP2-IN-17 2941498-93-5
V69759 SHP2-IN-18 2941498-87-7
V69749 SHP2-IN-19 2941498-84-4
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