yingweiwo

Proteasome

Proteasome

Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.

Proteasome related products

Structure Cat No. Product Name CAS No. Product Description
26S proteasome inhibitor I V2424 26S proteasome inhibitor I 858557-69-4 20S Proteasome-IN-1 is a 26S proteasome inhibitor.
5-Amino-8-hydroxyquinoline (5A8HQ) V73372 5-Amino-8-hydroxyquinoline (5A8HQ) 13207-66-4 5-Amino-8-hydroxyquinoline (5A8HQ) is a potential anticancer candidate active molecule with good proteasome inhibitory activity
Ac-ANW-AMC V73376 Ac-ANW-AMC 2357123-49-8 Ac-ANW-AMC is a fluorescent substrate for immunoproteasome.
Ac-Leu-Leu-Norleucinol V73379 Ac-Leu-Leu-Norleucinol 148333-42-0 Ac-Leu-Leu-Norleucinol is a calpain inhibitor that may be utilized to study acute liver injury caused by Acetaminophen and can reduce induced levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST).
Ac-Nle-Pro-Nle-Asp-AMC V73366 Ac-Nle-Pro-Nle-Asp-AMC 355140-49-7 Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate of the 26S proteasome.
Acetyl-Calpastatin(184-210)(human) TFA V77743 Acetyl-Calpastatin(184-210)(human) TFA Acetyl-Calpastatin(184-210)(human) TFA is a specific and reversible calpain inhibitor (antagonist) with Kis of 0.2 nM and 6 μM for μ-calpain and cathepsin L respectively.
Acetyl-Calpastatin(184-210)(human), Negative Control V85691 Acetyl-Calpastatin(184-210)(human), Negative Control
Alicapistat V4408 Alicapistat 1254698-46-8 Alicapistat (also known as ABT957; ABT-957) is a novel, potent,selective and orally bioactive inhibitor of humancalpains 1and2whose overactivation has been linked to Alzheimer disease (AD).
Anticancer agent 114 V77981 Anticancer agent 114 Anticancer agent 114 is an orally bioavailable dipeptide boronate proteasome inhibitor (antagonist) with IC50 of 2.2 nM.
ARI-3144 V84788 ARI-3144 1426305-25-0
BC-05 V60269 BC-05 2260717-73-3 BC-05 is an orally bioactive and potent inhibitor of CD13 and proteasome.
Calpain Inhibitor XI V73371 Calpain Inhibitor XI 145731-49-3 Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1.
Calpain Inhibitor-1 V73377 Calpain Inhibitor-1 1448429-06-8 Calpain Inhibitor-1 (compound 36) is a potent, selective inhibitor of the cysteine protease calpain 1 (Cal1) (IC50=100 nM; Ki=2.89 μM).
Calpain-2-IN-1 V51375 Calpain-2-IN-1 144231-85-6 Calpain-2-IN-1 (Formula 1A) is a potential surrogate calpain-2 isoform with Ki of 181 nM and 7.8 nM for calpain-1 and calpain-2, respectively.
Calpastatin subdomain B V73382 Calpastatin subdomain B 128578-18-7 Calpastatin subdomain B is a biologically active peptide.
Davelizomib V73373 Davelizomib 2409841-51-4 Davelizomib is a proteasome inhibitor (antagonist) with anti-tumor effects.
Dazcapistat (BLD-2660) V73367 Dazcapistat (BLD-2660) 2221010-42-8 Dazcapistat is a potent calpain inhibitor (antagonist) with IC50 of <3 μM for calpain 1, calpain 2 and calpain 9 (see patent WO2018064119A1, compound 405 for details).
DD1 inhibitor V2294 DD1 inhibitor 187585-11-1 DD1 is a proteasome inhibitor that activates/agonizes Bax and degrades P70S6K during the apoptosis process of acute myeloid leukemia (AML).
Enzyme-IN-1 V73368 Enzyme-IN-1 868540-02-7 Enzyme-IN-1 (compound 1) is a bioactive peptide-based N-terminal nucleophile (Ntn) hydrolase inhibitor.
EWFW-ACC V79360 EWFW-ACC EWFW-ACC is a tetrapeptide substrate of the immunoproteasome and is selective for the LMP7 subunit.
Contact Us