Proteasome

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Proteasome

Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.

Proteasome related products

Cat No.	Product Name	CAS No.	Product Description
V87692	20S Proteasome-IN-5		20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of 20S Proteasome with IC50 values of 0.19 and 52.5 μM for ChT-L and PGPH-L activities, respectively.
V2424	26S proteasome inhibitor I	858557-69-4	20S Proteasome-IN-1 is a 26S proteasome inhibitor.
V73372	5-Amino-8-hydroxyquinoline (5A8HQ)	13207-66-4	5-Amino-8-hydroxyquinoline (5A8HQ) is a potential anticancer candidate active molecule with good proteasome inhibitory activity
V73376	Ac-ANW-AMC	2357123-49-8	Ac-ANW-AMC is a fluorescent substrate for immunoproteasome.
V73379	Ac-Leu-Leu-Norleucinol	148333-42-0	Ac-Leu-Leu-Norleucinol is a calpain inhibitor that may be utilized to study acute liver injury caused by Acetaminophen and can reduce induced levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST).
V73366	Ac-Nle-Pro-Nle-Asp-AMC	355140-49-7	Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate of the 26S proteasome.
V87691	Ac-RLR-AMC	929903-87-7	Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm).
V87690	Ac-RLR-AMC TFA		Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm).
V77743	Acetyl-Calpastatin(184-210)(human) TFA		Acetyl-Calpastatin(184-210)(human) TFA is a specific and reversible calpain inhibitor (antagonist) with Kis of 0.2 nM and 6 μM for μ-calpain and cathepsin L respectively.
V85691	Acetyl-Calpastatin(184-210)(human), Negative Control
V77981	Anticancer agent 114		Anticancer agent 114 is an orally bioavailable dipeptide boronate proteasome inhibitor (antagonist) with IC50 of 2.2 nM.
V89021	Anticancer agent 233		Anticancer agent 233 (compound 5g) is a 3,5-bis(arylmethylene)-4-piperidinone derivative with anticancer activity, with GI50 values of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively.
V84788	ARI-3144	1426305-25-0
V60269	BC-05	2260717-73-3	BC-05 is an orally bioactive and potent inhibitor of CD13 and proteasome.
V87689	Bortezomib-pinanediol	205393-22-2	Bortezomib-pinanediol is a proteasome inhibitor and a prodrug of bortezomib.
V73371	Calpain Inhibitor XI	145731-49-3	Calpain Inhibitor XI is a reversible covalent inhibitor of calpain-1.
V73377	Calpain Inhibitor-1	1448429-06-8	Calpain Inhibitor-1 (compound 36) is a potent, selective inhibitor of the cysteine protease calpain 1 (Cal1) (IC50=100 nM; Ki=2.89 μM).
V51375	Calpain-2-IN-1	144231-85-6	Calpain-2-IN-1 (Formula 1A) is a potential surrogate calpain-2 isoform with Ki of 181 nM and 7.8 nM for calpain-1 and calpain-2, respectively.
V73382	Calpastatin subdomain B	128578-18-7	Calpastatin subdomain B is a biologically active peptide.
V87695	clasto-Lactacystin β-lactone	154226-60-5	Clasto-Lactacystin β-lactone is a natural active metabolite of lactacystin (a metabolite of Streptomyces) and an irreversible inhibitor of the 20S proteasome.