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5-HT Receptor

5-HT Receptor

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.

5-HT Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Norcisapride V87765 (+)-Norcisapride 202590-69-0 (+)-Norcisapride (Ticalopride) is a potent 5-HT4 agonist and 5-HT3 antagonist.
(+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) V71145 (+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) 19036-73-8 (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM).
(+)-Norfenfluramine hydrochloride V71147 (+)-Norfenfluramine hydrochloride DEA controlled substance schedule IV 37936-89-3 (+)-Norfenfluramine HCl is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM).
(+)-OSU6162 V84727 (+)-OSU6162 160777-43-5
(-)-5-HT2C agonist-3 V96924 (-)-5-HT2C agonist-3 2104810-16-2 (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, EC50 values for 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM.
(-)-Eseroline fumarate (Eseroline fumarate) V71190 (-)-Eseroline fumarate (Eseroline fumarate) 70310-73-5 (-)-Eseroline fumarate is a metabolite of the AChE inhibitor Physostigmine.
(R)-DOI hydrochloride V113218 (R)-DOI hydrochloride 82864-02-6 (R)-DOI hydrochloride is a selective 5-HT2A receptor agonist.
(R)-Indeloxazine benzenesulfonate V89038 (R)-Indeloxazine benzenesulfonate 1623762-83-3 (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor with IC50 values of 0.35 μM and 3.3 μM, respectively.
(R)-LY-41 V114741 (R)-LY-41 136296-43-0 (R)-LY-41 is the R-enantiomer of LY-41, which is a derivative of 2-S-aminotetrahydronaphthalene and an analog of 8-OH-DPAT.
（R，R）-盐酸帕洛司琼 V3896 (R,R)-Palonosetron Hydrochloride 135729-75-8 (R,R)-Palonosetron Hydrochloride isthe active R,R-enantiomer of Palonosetron HCl (RS25259, RS-25259 197; trade name: Aloxi and Akynzeo) which is a 5-HT3 antagonist approved in 2018 in the prevention and treatment of chemotherapy-induced nausea and vomiting.
(Rac)-Ulotaront hydrochloride V122045 (Rac)-Ulotaront hydrochloride 1310422-02-6 (Rac)-Ulotaront hydrochloride is the racemic form of urotalon hydrochloride.
(Rac)-WAY-161503 hydrochloride V71157 (Rac)-WAY-161503 hydrochloride 276695-22-8 (Rac)-WAY-161503 HCl is a specific, high-affinity 5-HT2C receptor agonist/activator with a Ki of 4 nM and EC50 of 12 nM.
(S)-5-HT2CR agonist 1 V115909 (S)-5-HT2CR agonist 1 2841458-00-0 (S)-5-HT2CR agonist 1 (compound (S)-16k) is a selective 5-HT2CR receptor agonist with an EC50 of 14 nM.
(S)-Bexicaserin V71196 (S)-Bexicaserin 2035818-21-2 (S)-Bexicaserin (Compound 2) is a 5-HT2C receptor agonist (activator) with potential for studying obesity and psychiatric-related diseases.
(S)-Ebalzotan V122166 (S)-Ebalzotan 294843-95-1 (S)-Ebalzotan is the S-isomer of Ebalzotan.
(S)-LY-41 V114524 (S)-LY-41 136296-40-7 (S)-LY-41 is the R-enantiomer of LY-41, which is a derivative of 2-S-aminotetrahydronaphthalene and an analog of 8-OH-DPAT.
(S)-PF-04995274 V104813 (S)-PF-04995274 2170558-28-6 (S)-PF-04995274 is a 5-hydroxytryptamine receptor 4 (5-HT4R) partial agonist and an isomer of PF-04995274.
(S)-Praziquantel V122210 (S)-Praziquantel 57452-97-8 (S)-Praziquantel is the inactive isomer of R-praziquantel.
(S)-Ramosetron V122213 (S)-Ramosetron 132036-90-9 (S)-Ramosetron is an orally effective 5-HT3 receptor antagonist.
(S)-Renzapride ((S)-BRL 24924) V77357 (S)-Renzapride ((S)-BRL 24924) (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride.
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