5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71145 | (+)-Norfenfluramine ((S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine) | 19036-73-8 | (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). |
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V71147 | (+)-Norfenfluramine hydrochloride | 37936-89-3 | (+)-Norfenfluramine HCl is the major hepatic metabolite of (+)-fenfluramine and is a selective 5-HT2B receptor agonist (Ki: 11.2 nM). |
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V71190 | (-)-Eseroline fumarate (Eseroline fumarate) | 70310-73-5 | (-)-Eseroline fumarate is a metabolite of the AChE inhibitor Physostigmine. |
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V3896 | (R,R)-Palonosetron Hydrochloride | 135729-75-8 | (R,R)-Palonosetron Hydrochloride isthe active R,R-enantiomer of Palonosetron HCl (RS25259, RS-25259 197; trade name: Aloxi and Akynzeo) which is a 5-HT3 antagonist approved in 2018 in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
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V71157 | (Rac)-WAY-161503 hydrochloride | 276695-22-8 | (Rac)-WAY-161503 HCl is a specific, high-affinity 5-HT2C receptor agonist/activator with a Ki of 4 nM and EC50 of 12 nM. |
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V71196 | (S)-Bexicaserin | 2035818-21-2 | (S)-Bexicaserin (Compound 2) is a 5-HT2C receptor agonist (activator) with potential for studying obesity and psychiatric-related diseases. |
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V77357 | (S)-Renzapride ((S)-BRL 24924) | (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. | |
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V71200 | 3,4-DihydroNaratriptan | 121679-20-7 | 3,4-Dihydro Naratriptan is a 5-HT1 receptor agonist. |
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V71181 | 4,4-Diphenylbutylamine hydrochloride | 22101-90-2 | The Kis of 4,4-Diphenylbutylamine for 5-HT2A and H1 receptors are 2589 and 1670 nM, respectively. |
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V71205 | 4-Butyl-alpha-agarofuran (Buagafuran; Buagarofuran) | 272126-07-5 | 4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant. |
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V71151 | 4F 4PP oxalate | 144734-36-1 | 4F 4PP (oxalate) is a selective 5-HT2A antagonist (inhibitor) with almost as high affinity as ketotryptamine (Ki= 5.3 nM) but much lower affinity for the 5-HT2C site (Ki= 620 nM ). |
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V71140 | 5-Carboxamidotryptamine (5-CT) | 74885-09-9 | 5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. |
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V71125 | 5-Carboxamidotryptamine maleate (5-CT maleate) | 74885-72-6 | 5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptor agonist (activator). |
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V71178 | 5-HT1A modulator 2 hydrochloride | 3880-76-0 | 5-HT1A modulator 2 HCl is an analogue of 8-OH-DPAT. |
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V71194 | 5-HT2 agonist-1 free base | 2708279-77-8 | 5-HT2 agonist-1 (Compound 24) free base is a 5-HT2A, 5-HT2B and 5-HT2C agonist/activator with IC50 of 10 nM, 8.3, and 1.6 nM respectively. |
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V71225 | 5-HT2A receptor agonist-1 | 2698331-34-7 | 5-HT2A receptor agonist-1 is a 5-HT2A receptor agonist/activator with EC50 of 5.54 nM. |
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V71198 | 5-HT2A receptor agonist-3 | 1391499-52-7 | 5-HT2A receptor agonist-3 is the most selective human 5-HT2A receptor agonist discovered so far, with a Ki of 2.5 nM. |
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V71218 | 5-HT2A&5-HT2C agonist-1 | 1640-02-4 | 5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A and 5-HT2C agonist/activator with IC50 of 196 nM and 0.9 nM respectively. |
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V71186 | 5-HT2agonist-1 | 2708279-78-9 | 5-HT2 agonist-1 (Compound 24) is a 5-HT2A, 5-HT2B, and 5-HT2C agonist/activator with IC50s of 10 nM, 8.3, and 1.6 nM, respectively. |
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V71201 | 5-HT2C agonist-3 | 2104810-18-4 | 5-HT2C agonist-3 ((+)-19) is a selective 5-HT2C agonist (EC50= 24 nM, Ki: 78 nM). |
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