Adenosine triphosphate (ATP) is converted into cyclic adenosine monophosphate (cAMP) by enzymes called adenylyl cyclases (ACs). Adenylyl cyclases combine extracellular stimuli with positive and negative signals that act through G protein-coupled cell-surface receptors in order to finely control cAMP levels inside of cells. Nine membrane-bound AC isoforms and one soluble AC are expressed in humans.
Transmembrane ACs are divided into four groups based on their regulatory characteristics: Group I contains the Ca2+/calmodulin-stimulated AC1, AC3, AC8, Group II contains the G-stimulated but Ca2+-insensitive AC2, AC4, AC7, Group III contains the Gi/Ca2+/PKA-inhibited AC5, AC6, and Group IV contains the forskolin/Ca2+/G-insensitive AC9. Forskolin, a diterpene obtained from the root of the plant Coleus forskohlii, which directly activates all isoforms of transmembrane ACs except AC9, has no effect on the soluble AC, unlike the transmembrane ACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74623 | Adenylyl cyclase-IN-1 | 731827-16-0 | Adenylyl cyclase-IN-1 is an inhibitor (blocker/antagonist) of adenylyl cyclase and may be used to be utilized in the research of ocular hypotonia. |
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V71481 | Albanin A (Albanin A) | 73343-42-7 | Albanin A is a flavonoid that can inhibit glutamate release and exerts neuro-protection effects in vivo by reducing Ca2+/calmodulin/adenylate cyclase 1 (AC1) activation in synaptosomes. |
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V23223 | KH7 | 330676-02-3 | KH7 (KH-7) is a novel and potent Inhibitor of Sac (soluble adenylyl cyclase) with IC50s of 3-10 μM against both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. |
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V19556 | Lypressin | 50-57-7 | Lysipressin (Lysine vasopressin) is an antidiuretic hormone discovered in pigs. |
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V74621 | Lysipressin acetate (Lysine vasopressin acetate; [Lys8]-Vasopressin acetate) | 83968-49-4 | Lysipressin (Lysine vasopressin) acetate is an antidiuretic hormone discovered in pigs. |
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V80661 | mAC2-IN-1 | mAC2-IN-1 (compound 14) is a potent and specific inhibitor of human adenylyl cyclase (mAC) with IC50 of 4.45 μM. | |
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V74624 | Mant-GTPγS | 136749-24-1 | Mant-GTPγS is a GTP mimetic and a potent competitive adenylyl cyclase (AC) inhibitor. |
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V80678 | Mant-GTPγS triammonium | Mant-GTPγS triammonium is a GTP mimetic and a potent competitive adenylyl cyclase (AC) inhibitor. | |
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V2586 | SQ22536 (NSC-53339) | 17318-31-9 | SQ22536 (formerly NSC-53339) is a novel and effective inhibitor of adenylyl cyclase(AC) with an IC50 of 1.4 μM. |
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V74619 | TDI-10229 | 2810887-45-5 | TDI-10229 is an orally bioactive soluble adenylyl cyclase (sAC, ADCY10) inhibitor (IC50 195 nM). |
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V74620 | TDI-11861 | 2857049-72-8 | TDI-11861 is a second-generation inhibitor of soluble adenylyl cyclase (sAC) with a slow off-rate. |
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V74622 | Zelminemab (AMG-301) | 2225850-33-7 | Zelminemab (AMG-301) is a human monoclonal antibody (mAb) that can inhibit the PACAP type I (PAC1) receptor. |
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