The major HCO3- transporter of the renal proximal tubule (PiT), which is situated at the basolateral membrane (BLM), is the electrogenic Na/HCO3 cotransporter (symporter), which also contributes significantly to Na+ reabsorption. Most cells' intracellular pH (pHi) is controlled by HCO3 transporters, which also affects blood pH. The proximal renal tubules from perfused Ambystoma tigrinum (salamander) were used to discover this electrogenic Na/HCO3 cotransporter. This novel cotransporter, which is electrogenic and mediates the movement of one Na+ ion with multiple HCO3- ions, does not rely on intracellular or extracellular Cl- and is blocked by stilbene compounds. This cotransporter as well as others like it have been identified in various tissues and cell types.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V135140 | EOS789 | 1628848-73-6 | EOS789 is an orally effective sodium-dependent phosphate transporter inhibitor with IC50 values of 6.8, 1.5, and 1.7 μM for human NaPi-IIb, PiT-1, and PiT-2, respectively; and IC50 values of 3.9, 1.9, and 1.7 μM for rat NaPi-IIb, PiT-1, and PiT-2, respectively. |
|
V139159 | LY3358966 | 2187395-66-8 | LY3358966 is an orally effective inhibitor of sodium-dependent phosphate cotransporter 2b (NPT2b), with IC50 values of 32.4 nM, 43.9 nM, and 26.8 nM in humans, mice, and rats, respectively. |
|
V2877 | S0859 | 1019331-10-2 | S0859 (S-0859) is an N-cyanosulphonamide compound acting as a novel, selective, high-affinity genericinhibitor of NBC [(Na(+)-coupled HCO(3)(-) transporters]. |
|
V145090 | SOAT-IN-2 | 3056727-95-5 | SOAT-IN-2 is a selective inhibitor of sodium-dependent organic anion transporter (SOAT, SLC10A6). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
