Oxytocin Receptor

Oxytocin Receptor

The G-protein-coupled seven-transmembrane receptor superfamily includes the oxytocin receptor. Its primary physiological function is to control the smooth muscle contraction of the uterus during labor and the release of milk from the lactating breast. The binding of oxytocin and a related nonapeptide, vasopressin, causes the oxytocin receptors to become active. Multiple neuroendocrine and cognitive processes are regulated by the oxytocin receptor by Gi or Gq protein-mediated signaling cascades.

A nonapeptide belonging to the family of neurohypophyseal proteins, oxytocin specifically binds to the oxytocin receptor to trigger numerous central and peripheral physiological reactions. Oxytocin is a paracrine and/or autocrine mediator of a variety of biological effects in vivo. The interactions with G-protein-coupled oxytocin/vasopressin receptors, which, through Gq and Gi, stimulate phospholipase C-mediated hydrolysis of phosphoinositides, are the main mechanism by which these effects are exerted.

Oxytocin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V74430 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin 77327-45-8
V74428 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin 115499-13-3
V74425 (Val3,Pro8)-Oxytocin 2134138-89-7
V74427 [Asp5]-Oxytocin 65907-78-0
V77767 [Asp5]-Oxytocin acetate
V11854 Atosiban acetate 914453-95-5 Atosiban acetate, the acetate salt of Atosiban (RW-22164; Tractocile; RWJ22164), is a novel and potent peptide-based oxytocin and vasopressin antagonist with the potential to be used for spontaneous preterm labor.
V74429 Barusiban (FE-200440) 285571-64-4
V30719 Carbetocin 37025-55-1 Carbetocin is a novel and potent obstetric drug acting as an agonist of the oxytocin receptor (Kiof 7.1 nM) with improved in vivo stability over oxytocin.
V74426 Carbetocin acetate 1631754-28-3
V74433 OT antagonist 1 demethyl derivative 2763705-17-3
V81102 PF-06478939
V81103 PF-06478939 TFA
V81104 PF-06655075 TFA
V74431 Pro8-Oxytocin 24327-19-3
V81200 Pro8-Oxytocin TFA
V3619 Retosiban (GSK 221149; GSK 221149A) 820957-38-8 Retosiban(GSK-221149; GSK-221149A)is a novel, potent, orally bioactive, and selective, sub-nanomolar oxytocin receptor antagonist with Ki of 0.65 nM and >1400-fold selectivity over the related vasopressin receptors.
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