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Oxytocin Receptor

Oxytocin Receptor

The G-protein-coupled seven-transmembrane receptor superfamily includes the oxytocin receptor. Its primary physiological function is to control the smooth muscle contraction of the uterus during labor and the release of milk from the lactating breast. The binding of oxytocin and a related nonapeptide, vasopressin, causes the oxytocin receptors to become active. Multiple neuroendocrine and cognitive processes are regulated by the oxytocin receptor by Gi or Gq protein-mediated signaling cascades.

A nonapeptide belonging to the family of neurohypophyseal proteins, oxytocin specifically binds to the oxytocin receptor to trigger numerous central and peripheral physiological reactions. Oxytocin is a paracrine and/or autocrine mediator of a variety of biological effects in vivo. The interactions with G-protein-coupled oxytocin/vasopressin receptors, which, through Gq and Gi, stimulate phospholipase C-mediated hydrolysis of phosphoinositides, are the main mechanism by which these effects are exerted.

Oxytocin Receptor related products

Structure Cat No. Product Name CAS No. Product Description
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin V74430 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin 77327-45-8 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) is an oxytocin receptor blocker (antagonist).
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin V74428 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin 115499-13-3 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor blocker (antagonist), eliminates oxytocin-potentiated inhibitory processes in CA1 pyramidal neurons Aftertouch current.
(Val3,Pro8)-Oxytocin V74425 (Val3,Pro8)-Oxytocin 2134138-89-7 (Val3,Pro8)-Oxytocin is a Gq-dependent pathway agonist.
[Asp5]-Oxytocin V74427 [Asp5]-Oxytocin 65907-78-0 [Asp5]-Oxytocin is a potent 5-position neurohypophyseal hormone analog.
[Asp5]-Oxytocin acetate V77767 [Asp5]-Oxytocin acetate [Asp5]-Oxytocin acetate is a potent 5-position neurohypophyseal hormone analog.
Barusiban (FE-200440) V74429 Barusiban (FE-200440) 285571-64-4 Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM) that can inhibit OT-induced contractions.
Carbetocin acetate V74426 Carbetocin acetate 1631754-28-3 Carbetocin acetate is an oxytocin (OT) analogue and oxytocin receptor agonist/activator with Ki of 7.1 nM.
Kalata B7 V86702 Kalata B7 339532-29-5 Kalata B7 is a membrane permeable cyclic peptide isolated from Oldenlandia affinis DC (Rubiaceae).
OT antagonist 1 demethyl derivative V74433 OT antagonist 1 demethyl derivative 2763705-17-3 OT antagonist 1 demethyl analogue is the demethylated product of OT antagonist 1.
PF-06478939 V81102 PF-06478939 PF-06478939 is a non-brain-penetrating peptide that has agonistic effects on oxytocin (OT) receptors and vasopressin receptors with EC50s of 0.01 nM and 0.078 nM, respectively.
PF-06478939 TFA V81103 PF-06478939 TFA PF-06478939 (TFA) is a non-brain-penetrating peptide that is an agonist at oxytocin (OT) receptors and vasopressin receptors with EC50s of 0.01 nM and 0.078 nM, respectively.
PF-06655075 TFA V81104 PF-06655075 TFA PF-06655075 (TFA) is the TFA form of PF-06655075.
Pro8-Oxytocin V74431 Pro8-Oxytocin 24327-19-3 Pro8-Oxytocin is a modified oxytocin (OXT) ligand.
Pro8-Oxytocin TFA V81200 Pro8-Oxytocin TFA Pro8-Oxytocin TFA is a modified oxytocin (OXT) ligand.
Retosiban (GSK 221149; GSK 221149A) V3619 Retosiban (GSK 221149; GSK 221149A) 820957-38-8 Retosiban(GSK-221149; GSK-221149A)is a novel, potent, orally bioactive, and selective, sub-nanomolar oxytocin receptor antagonist with Ki of 0.65 nM and >1400-fold selectivity over the related vasopressin receptors.
卡贝缩宫素 V30719 Carbetocin 37025-55-1 Carbetocin is a novel and potent obstetric drug acting as an agonist of the oxytocin receptor (Kiof 7.1 nM) with improved in vivo stability over oxytocin.
醋酸阿托西班 V11854 Atosiban acetate 914453-95-5 Atosiban acetate, the acetate salt of Atosiban (RW-22164; Tractocile; RWJ22164), is a novel and potent peptide-based oxytocin and vasopressin antagonist with the potential to be used for spontaneous preterm labor.
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