Xanthine oxidase (XO), a multifunctional molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and then the subsequent reduction of oxygen at the flavin center with the production of reactive oxygen species, either superoxide anion radicals or hydrogen peroxide.
The purine catabolism pathway's key enzyme, xanthine oxidase, has been linked indirectly to a number of pathological conditions, including cancer, diabetes, and metabolic syndrome, as well as directly to the pathogenesis of gout. Gout, cancer, inflammation, and oxidative damage may all be treated therapeutically by selectively inhibiting xanthine oxidase.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V107913 | 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro- | 13392-26-2 | (+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM found in Plantago asiatica (Psyllium). |
|
V111094 | 5,6,7-Trihydroxy-4'-methoxyflavone | 6563-66-2 | 5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-methylbaicalein) is a flavonoid compound and a weak inhibitor of xanthine oxidase. |
|
V71967 | 7,8,3′,4′-Tetrahydroxyflavone | 3440-24-2 | 7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor (antagonist) with IC50 of 10.488 µM. |
|
V87760 | Amflutizole | 82114-19-0 | Amflutizole (LY-141894) is a xanthine oxidase inhibitor. |
|
V71969 | Aurantiamide benzoate | 150881-02-0 | Aurantiamide benzoate is a naturally occurring compound extracted from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. |
|
V71981 | Baicalein 6-O-glucoside | 28279-72-3 | Baicalein 6-O-glucoside is the glucuronidation metabolite of Baicalein. |
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V87758 | Baicalein hydrate | 352000-07-8 | Baicalein hydrate (5,6,7-Trihydroxyflavone hydrate) is a xanthine oxidase inhibitor with IC50 value of 3.12 μM. |
|
V87761 | BOF-4272 | 142181-44-0 | BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. |
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V111305 | Neosakuranin | 31187-54-9 | Neospermone is a flavonoid compound that can be extracted from the bark of cherry (P. cerasus) and rowan (Sorbus commixta). |
|
V87762 | Oxypurinol-13C,15N2 | Oxypurinol-13C,15N2 is 15N and 13C labeled Oxypurinol. | |
|
V112360 | Procyanidin B2 3′-O-gallate | 73086-04-1 | Rhodiola rosea extract proanthocyanidin B2 3′-O-gallate (B2-3′-G) is a potent xanthine oxidase (XO) inhibitor (IC50 = 24.24 μM, Ki = 6.16 μM). |
|
V85211 | Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) | 18103-42-9 | |
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V71978 | URAT1&XO inhibitor 1 | 2669726-78-5 | URAT1&XO inhibitor 1 (compound 29) is a dual (bifunctional) inhibitor of URAT1 (IC50=~10μM) and xanthine oxidase (IC50=1.01μM). |
|
V80852 | Xanthine oxidase-IN-11 | Xanthine oxidase-IN-11 (XO8 analog) is a xanthine oxidase (XO) inhibitor. | |
|
V87756 | Xanthine oxidase-IN-13 | Xanthine oxidase-IN-13 (Compound 10) is a selective xanthine oxidase inhibitor (IC50 for bovine xanthine oxidase is 149.56 μM). | |
|
V87759 | Xanthine oxidase-IN-14 | 80025-67-8 | Xanthine oxidase-IN-14 (Compound 3f) is a xanthine oxidase inhibitor with IC50 >100 μM. |
|
V87757 | Xanthine oxidase-IN-15 | Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC50=0.13 μM). | |
|
V94861 | Xanthine oxidase-IN-16 | Xanthine Oxidase-IN-16 is a potent, oral xanthine oxidase (XO) inhibitor with IC50 of 102 nM. | |
|
V117411 | Xanthine oxidase-IN-18 | IN-18, a xanthine oxidase inhibitor, is a potent oral xanthine oxidase (XO) inhibitor (IC50 = 0.263 μM). | |
|
V115779 | Xanthine oxidase-IN-19 | 3055301-22-6 | Xanthine oxidase-IN-19 (compound 13i) is an orally effective xanthine oxidase (XO) inhibitor with an IC50 value of 0.2 μM. |
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