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Xanthine Oxidase

Xanthine Oxidase

Xanthine oxidase (XO), a multifunctional molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and then the subsequent reduction of oxygen at the flavin center with the production of reactive oxygen species, either superoxide anion radicals or hydrogen peroxide.

The purine catabolism pathway's key enzyme, xanthine oxidase, has been linked indirectly to a number of pathological conditions, including cancer, diabetes, and metabolic syndrome, as well as directly to the pathogenesis of gout. Gout, cancer, inflammation, and oxidative damage may all be treated therapeutically by selectively inhibiting xanthine oxidase.

Xanthine Oxidase related products

Structure Cat No. Product Name CAS No. Product Description
7,8,3′,4′-Tetrahydroxyflavone V71967 7,8,3′,4′-Tetrahydroxyflavone 3440-24-2 7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor (antagonist) with IC50 of 10.488 µM.
Amflutizole V87760 Amflutizole 82114-19-0 Amflutizole (LY-141894) is a xanthine oxidase inhibitor.
Aurantiamide benzoate V71969 Aurantiamide benzoate 150881-02-0 Aurantiamide benzoate is a naturally occurring compound extracted from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata.
Baicalein 6-O-glucoside V71981 Baicalein 6-O-glucoside 28279-72-3 Baicalein 6-O-glucoside is the glucuronidation metabolite of Baicalein.
Baicalein hydrate V87758 Baicalein hydrate 352000-07-8 Baicalein hydrate (5,6,7-Trihydroxyflavone hydrate) is a xanthine oxidase inhibitor with IC50 value of 3.12 μM.
BOF-4272 V87761 BOF-4272 142181-44-0 BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor.
Oxypurinol-13C,15N2 V87762 Oxypurinol-13C,15N2 Oxypurinol-13C,15N2 is 15N and 13C labeled Oxypurinol.
Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) V85211 Tricetin 3',4',5'-trimethyl ether (5,7-Dihydroxy-3',4',5'-trimethoxyflavone) 18103-42-9
URAT1&XO inhibitor 1 V71978 URAT1&XO inhibitor 1 2669726-78-5 URAT1&XO inhibitor 1 (compound 29) is a dual (bifunctional) inhibitor of URAT1 (IC50=~10μM) and xanthine oxidase (IC50=1.01μM).
Xanthine oxidase-IN-11 V80852 Xanthine oxidase-IN-11 Xanthine oxidase-IN-11 (XO8 analog) is a xanthine oxidase (XO) inhibitor.
Xanthine oxidase-IN-13 V87756 Xanthine oxidase-IN-13 Xanthine oxidase-IN-13 (Compound 10) is a selective xanthine oxidase inhibitor (IC50 for bovine xanthine oxidase is 149.56 μM).
Xanthine oxidase-IN-14 V87759 Xanthine oxidase-IN-14 80025-67-8 Xanthine oxidase-IN-14 (Compound 3f) is a xanthine oxidase inhibitor with IC50 >100 μM.
Xanthine oxidase-IN-15 V87757 Xanthine oxidase-IN-15 Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC50=0.13 μM).
XOR/URAT1-IN-1 V87251 XOR/URAT1-IN-1 2810137-86-9 XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor of xanthine oxidoreductase (XOR) and urate transporter 1 (URAT1) with IC50 of 6 nM and 12.9 μM, respectively.
非布索坦 V2072 Febuxostat (TEI 6720; TMX 67) 144060-53-7 Febuxostat (formerly also called TMX 67, TEI-6720; TEI 6720; Uloric; TMX-67)is a potent and selective xanthine oxidase inhibitor with Ki of 0.6 nM and has been used to treat hyperuricemia and chronic gout.
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