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Sirtuin

Sirtuin

The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.

Sirtuin related products

Structure Cat No. Product Name CAS No. Product Description
2-APQC V88772 2-APQC 500271-63-6 2-APQC is a SIRT3 agonist with a Kd of 2.756 μM.
3-TYP V2098 3-TYP 120241-79-4 3-TYP [3TYP; full/chemical name: 3-(1H-1,2,3-triazol-4-yl) pyridine)] is a novel, potent and selective SIRT3 inhibitor (IC50 = 16 nM) with high selectivity for SIRT3 over SIRT1 (IC50=88 nM) and SIRT2 (IC50=92 nM).
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol V75478 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol 97744-95-1 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a SIRT1 activator with anti-tumor effects.
5-Heptadecylresorcinol (5-n-Heptadecylresorcinol; AR-C17) V52492 5-Heptadecylresorcinol (5-n-Heptadecylresorcinol; AR-C17) 41442-57-3 5-Heptadecylresorcinol (AR-C17) is a phenolic lipid component and an orally bioavailable mitochondrial protectant.
6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline V127263 6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline 342397-19-7 6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline is a SIRT1 inhibitor with a KD value of 0.5 μM.
7-Chloro-4-(piperazin-1-yl)quinoline V52960 7-Chloro-4-(piperazin-1-yl)quinoline 837-52-5 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in active molecular chemistry.
8AQ−Cu−5Iu V85875 8AQ−Cu−5Iu
Ac-QPKK(Ac)-AMC V88778 Ac-QPKK(Ac)-AMC 1387005-23-3 Ac-QPKK(Ac)-AMC is the fluorescent substrate of Sirtuin and generates fluorescence through Sirtuin deacetylation.
ADTL-SA1215 V53085 ADTL-SA1215 782387-91-1 ADTL-SA1215 is a specific SIRT3 small molecule activator that regulates autophagy in triple-negative breast cancer.
Ainsliadimer C V55734 Ainsliadimer C 1365995-73-8 Ainsliadimer C is a potential SIRT1 activator that improves the inflammatory response in adipose tissue.
Antiproliferative agent-17 V34830 Antiproliferative agent-17 2882206-08-6 antiproliferation agent-17 is an antiproliferation agent.
Aristoforin V129430 Aristoforin 849215-53-8 Aristoforin is a derivative of hypericin that can inhibit the activity of SIRT1 and SIRT2.
BF-175 V114894 BF-175 1333375-02-2 BF-175 is a selective SIRT1 agonist.
Cannabisin F V52301 Cannabisin F 163136-19-4 Cannabisin F is a SIRT1 modulator.
CAY10602 HCl V2358 CAY10602 HCl CAY-10602 HCl, the hydrochloride salt of CAY10602, is a novel and potentSIRT1activator identified from HTS/high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
Citriniorl A V131820 Citriniorl A Citriniorl A is a SIRT1 enhancer with an EC50 value of 5.8 μM.
CL5D V131862 CL5D 2488745-53-3 CL5D is an activator of the protein deacetylase SIRT6.
CrBKA V53405 CrBKA 2260810-48-6 CrBKA is a weakly active fluorescent small molecule substrate of SIRT6.
CypD-IN-3 V52204 CypD-IN-3 2651994-75-9 CypD-IN-3 is a potent isoform-selective cyclophilin D (CypD) inhibitor.
DCHC V103229 DCHC 302953-06-6 DCHC is a SIRT1 activator but does not induce SIRT1 expression.
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