The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2098 | 3-TYP | 120241-79-4 | 3-TYP [3TYP; full/chemical name: 3-(1H-1,2,3-triazol-4-yl) pyridine)] is a novel, potent and selective SIRT3 inhibitor (IC50 = 16 nM) with high selectivity for SIRT3 over SIRT1 (IC50=88 nM) and SIRT2 (IC50=92 nM). |
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V75478 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol | 97744-95-1 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a SIRT1 activator with anti-tumor effects. |
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V52492 | 5-Heptadecylresorcinol (5-n-Heptadecylresorcinol; AR-C17) | 41442-57-3 | 5-Heptadecylresorcinol (AR-C17) is a phenolic lipid component and an orally bioavailable mitochondrial protectant. |
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V52960 | 7-Chloro-4-(piperazin-1-yl)quinoline | 837-52-5 | 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in active molecular chemistry. |
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V53085 | ADTL-SA1215 | 782387-91-1 | ADTL-SA1215 is a specific SIRT3 small molecule activator that regulates autophagy in triple-negative breast cancer. |
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V55734 | Ainsliadimer C | 1365995-73-8 | Ainsliadimer C is a potential SIRT1 activator that improves the inflammatory response in adipose tissue. |
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V34830 | Antiproliferative agent-17 | 2882206-08-6 | antiproliferation agent-17 is an antiproliferation agent. |
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V52301 | Cannabisin F | 163136-19-4 | Cannabisin F is a SIRT1 modulator. |
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V2358 | CAY10602 HCl | CAY-10602 HCl, the hydrochloride salt of CAY10602, is a novel and potentSIRT1activator identified from HTS/high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. | |
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V53405 | CrBKA | 2260810-48-6 | CrBKA is a weakly active fluorescent small molecule substrate of SIRT6. |
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V52204 | CypD-IN-3 | 2651994-75-9 | CypD-IN-3 is a potent isoform-selective cyclophilin D (CypD) inhibitor. |
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V75479 | Epigenetic factor-IN-1 | 2640673-56-7 | Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor. |
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V53029 | Et-29 | 2166487-23-4 | Et-29 is a potent and specific inhibitor of SIRT5 (Ki=40 nM). |
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V53162 | Gardenia yellow (crocin I) | 94238-00-3 | Gardenia yellow is a member of the crocin family. |
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V55732 | Guttiferone G | 666174-75-0 | Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50 9 and 22 μM, respectively). |
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V22525 | Inauhzin | 309271-94-1 | Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
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V51303 | JGB-1741 (ILS-JGB-1741) | 1256375-38-8 | JGB1741 (ILS-JGB-1741) is a novel SIRT1 activity inhibitor with an IC50 of ~15 μM. |
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V55733 | Lumbokinase capsules | 556743-18-1 | Lumbokinase capsules attenuate myocardial ischemia-reperfusion (IR) injury by activating Sirt1 signaling, thereby enhancing autophagic flux and reducing IR-induced oxidative damage, inflammation, and apoptosis. |
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V51803 | MC3482 | 2922280-86-0 | MC3482 is a specific sirtuin5 (SIRT5) inhibitor. |
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V75475 | MDL-811 | 2275619-98-0 | MDL-811 is a heterogeneous activator of SIRT6 and can significantly activate the deacetylation of histone H3 (H3K9Ac, H3K18Ac, and H3K56Ac) by SIRT6. |
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