The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V88772 | 2-APQC | 500271-63-6 | 2-APQC is a SIRT3 agonist with a Kd of 2.756 μM. |
|
V2098 | 3-TYP | 120241-79-4 | 3-TYP [3TYP; full/chemical name: 3-(1H-1,2,3-triazol-4-yl) pyridine)] is a novel, potent and selective SIRT3 inhibitor (IC50 = 16 nM) with high selectivity for SIRT3 over SIRT1 (IC50=88 nM) and SIRT2 (IC50=92 nM). |
|
V75478 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol | 97744-95-1 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a SIRT1 activator with anti-tumor effects. |
|
V52492 | 5-Heptadecylresorcinol (5-n-Heptadecylresorcinol; AR-C17) | 41442-57-3 | 5-Heptadecylresorcinol (AR-C17) is a phenolic lipid component and an orally bioavailable mitochondrial protectant. |
|
V52960 | 7-Chloro-4-(piperazin-1-yl)quinoline | 837-52-5 | 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in active molecular chemistry. |
|
V85875 | 8AQ−Cu−5Iu | ||
|
V88778 | Ac-QPKK(Ac)-AMC | 1387005-23-3 | Ac-QPKK(Ac)-AMC is the fluorescent substrate of Sirtuin and generates fluorescence through Sirtuin deacetylation. |
|
V53085 | ADTL-SA1215 | 782387-91-1 | ADTL-SA1215 is a specific SIRT3 small molecule activator that regulates autophagy in triple-negative breast cancer. |
|
V55734 | Ainsliadimer C | 1365995-73-8 | Ainsliadimer C is a potential SIRT1 activator that improves the inflammatory response in adipose tissue. |
|
V34830 | Antiproliferative agent-17 | 2882206-08-6 | antiproliferation agent-17 is an antiproliferation agent. |
|
V52301 | Cannabisin F | 163136-19-4 | Cannabisin F is a SIRT1 modulator. |
|
V2358 | CAY10602 HCl | CAY-10602 HCl, the hydrochloride salt of CAY10602, is a novel and potentSIRT1activator identified from HTS/high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. | |
|
V53405 | CrBKA | 2260810-48-6 | CrBKA is a weakly active fluorescent small molecule substrate of SIRT6. |
|
V52204 | CypD-IN-3 | 2651994-75-9 | CypD-IN-3 is a potent isoform-selective cyclophilin D (CypD) inhibitor. |
|
V75479 | Epigenetic factor-IN-1 | 2640673-56-7 | Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor. |
|
V53029 | Et-29 | 2166487-23-4 | Et-29 is a potent and specific inhibitor of SIRT5 (Ki=40 nM). |
|
V88774 | FLS-359 | 2309398-79-4 | FLS-359 is an orally available allosteric selective modulator of sirtuin 2 with IC50 of 3 μM. |
|
V53162 | Gardenia yellow (crocin I) | 94238-00-3 | Gardenia yellow is a member of the crocin family. |
|
V55732 | Guttiferone G | 666174-75-0 | Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50 9 and 22 μM, respectively). |
|
V88775 | hsa62 | 780822-35-7 | hsa62 is an inhibitor of SIRT1 and SIRT2 with IC50 of 1.3 and 5.5 μM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
