The class of proteins known as Sirtuin (Sir2 proteins) includes enzymes with deacylase, deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase activity. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V88772 | 2-APQC | 500271-63-6 | 2-APQC is a SIRT3 agonist with a Kd of 2.756 μM. |
|
V2098 | 3-TYP | 120241-79-4 | 3-TYP [3TYP; full/chemical name: 3-(1H-1,2,3-triazol-4-yl) pyridine)] is a novel, potent and selective SIRT3 inhibitor (IC50 = 16 nM) with high selectivity for SIRT3 over SIRT1 (IC50=88 nM) and SIRT2 (IC50=92 nM). |
|
V75478 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol | 97744-95-1 | 3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a SIRT1 activator with anti-tumor effects. |
|
V52492 | 5-Heptadecylresorcinol (5-n-Heptadecylresorcinol; AR-C17) | 41442-57-3 | 5-Heptadecylresorcinol (AR-C17) is a phenolic lipid component and an orally bioavailable mitochondrial protectant. |
|
V127263 | 6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline | 342397-19-7 | 6,7-Dimethoxy-1,3-bis(4-methoxyphenyl)isoquinoline is a SIRT1 inhibitor with a KD value of 0.5 μM. |
|
V52960 | 7-Chloro-4-(piperazin-1-yl)quinoline | 837-52-5 | 7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in active molecular chemistry. |
|
V85875 | 8AQ−Cu−5Iu | ||
|
V88778 | Ac-QPKK(Ac)-AMC | 1387005-23-3 | Ac-QPKK(Ac)-AMC is the fluorescent substrate of Sirtuin and generates fluorescence through Sirtuin deacetylation. |
|
V53085 | ADTL-SA1215 | 782387-91-1 | ADTL-SA1215 is a specific SIRT3 small molecule activator that regulates autophagy in triple-negative breast cancer. |
|
V0436 | AGK2 | 304896-28-4 | AGK2 is a novel, potent, and selective inhibitor of SIRT2 (sirtuin 2, histone deacetylase) with potential anti-inflammatory activity. |
|
V55734 | Ainsliadimer C | 1365995-73-8 | Ainsliadimer C is a potential SIRT1 activator that improves the inflammatory response in adipose tissue. |
|
V6633 | AK-1 | 330461-64-8 | AK-1 is a potent, specific and cell-penetrating/penetrable SIRT2 inhibitor (antagonist) with IC50 of 12.5 μM. |
|
V4086 | AK-7 | 420831-40-9 | AK-7 (also known as AK7, CS-3223 and GL-8955) is a novel, selective, cell- and brain-permeable SITR2 inhibitor with the potential to be used for the treatment of Parkinsons disease and Huntingtons disease (HD). |
|
V34830 | Antiproliferative agent-17 | 2882206-08-6 | antiproliferation agent-17 is an antiproliferation agent. |
|
V129430 | Aristoforin | 849215-53-8 | Aristoforin is a derivative of hypericin that can inhibit the activity of SIRT1 and SIRT2. |
|
V114894 | BF-175 | 1333375-02-2 | BF-175 is a selective SIRT1 agonist. |
|
V3226 | Cambinol | 14513-15-6 | Cambinol (formerly NSC-112546) is a potent SIRT (silent information regulator enzymes) inhibitor withIC50values of 56 and 59 μM for SIRT1andSIRT2, respectively. |
|
V52301 | Cannabisin F | 163136-19-4 | Cannabisin F is a SIRT1 modulator. |
|
V2111 | CAY10602 | 374922-43-7 | CAY10602 (CAY-10602) is a novel and potentSIRT1activator. |
|
V2358 | CAY10602 HCl | CAY-10602 HCl, the hydrochloride salt of CAY10602, is a novel and potentSIRT1activator identified from HTS/high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
