A non-apoptotic type of controlled cell death is ferroptosis. It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3.Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.
Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V103322 | (1R,3R)-Ferroptosis inducer-1 | 2375357-97-2 | (1R,3R)-Ferroptosis is an isomer of ferroptosis inducer-1. |
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V120405 | (1R,3R)-RSL3 | 1219810-15-7 | |
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V118449 | 1,4-Naphthoquinone-NH-C2-NH-Trolox | 1,4-Naphthoquinone-NH-C2-NH-Trolox is a neuroprotective compound of Trolox and vitamin K that can cross the blood-brain barrier. | |
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V109452 | 3-Hydroxyindole | 480-93-3 | 3-Hydroxyindole is a hydroxyindole compound with antioxidant activity that can inhibit the scavenging of DPPH and crocin. |
![[2H3]-罗格列酮标准品](http://www.invivochem.com/upload/1124/V51332.png)
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V51332 | Rosiglitazone-d3 (BRL-49653-d3) | 1132641-22-5 | deuterated form of Rosiglitazone |
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V118606 | afi-FSP1-1 | 3072951-35-7 | afi-FSP1-1 is an inhibitor of ferroptosis inhibitor protein 1 (FSP1) with a Ki value of 0.283 μM. |
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V79509 | Anticancer agent 154 | Anticancer agent 154 (Compound 8h) increases levels of reactive oxygen species and causes mitochondrial damage. | |
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V105417 | BG11 | 3065877-52-0 | BG11 induces the accumulation of Fe2+ and intracellular lipid peroxides, inducing ferroptosis. |
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V3193 | CA3 (CIL-56) | 300802-28-2 | CA3 (also known as CIL56) is a novel and potent inhibitor ofYAP1/Teadtranscriptional activity. |
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V18692 | CP-24879 hydrochloride | 10141-51-2 | CP-24879 hydrochloride (CP24879; p-isopentoxyaniline)) is a novel and potent dual inhibitor of D5D/D6D (delta5 and/or the delta6) fatty acid desaturasewithantisteatotic and anti-inflammatory activity. |
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V105052 | DefNEtTrp | DefNEtTrp is an iron double chelating ligand composed of two groups, Def and Trp. | |
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V120119 | Diplacone | 73676-38-7 | Benzophenone (DP) is a geraniol-type flavanone. |
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V79163 | DL-alpha-Tocopherol-13C3 (DL-alpha-Tocopherol 13C3) | DL-alpha-Tocopherol-13C3 is a 13C (carbon 13)-labeled DL-alpha-Tocopherol. | |
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V77077 | DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride; BSO hydrochloride) | DL-Buthionine-(S,R)-sulfoximine HCl (Buthionine sulfoximine HCl) is a potent inhibitor of glutamylcysteine synthetase biosynthesis. | |
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V103931 | Ebselen derivative 1 | 3030492-59-9 | Ebselen derivative 1 (compound 19) is an orally active glutathione peroxidase (GPx) analog. |
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V79369 | FA16 | 3037775-42-8 | FA16 is a specific, metabolically stable ferroptosis inducer (IC50=1.26 μM; HT1080 cells) and is an analogue of 2-(trifluoromethyl) benzimidazole. |
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V104496 | FerroLOXIN-1 | 2773428-48-9 | FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocks the production of pro-ferroptotic HOO-ETE-PE and prevents RSL3-induced ferroptosis. |
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V118471 | Ferroptosis inducer-10 | Ferrocyte inducer-10 is a ferroptosis inducer. | |
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V118644 | Ferroptosis inducer-11 | Ferrocyte inducer-11 is a ferroptosis inducer. | |
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V117222 | Ferroptosis inducer-12 | Ferrocyte inducer-12 is a highly effective and selective ferroptosis inducer. |
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