Opioid ligands are a class of G protein-coupled receptors known as opioid receptors. Dynorphins, enkephalins, endorphins, endomorphins, and nociceptin are examples of endogenous opioids. There are many opioid receptors in the brain, as well as in the spinal cord and digestive system. The body has molecules or sites called opioid receptors that are triggered by opioid substances.Opioid receptors prevent impulses from traveling along excitatory pathways in the human body. The serotonin, catecholamine, and substance P pathways are some of these pathways, and they are all thought to play a role in pain perception and feelings of wellbeing. Mu, delta, and kappa receptors are additional subclassifications of opioid receptors. While each class has its own unique way of acting, they all have some fundamental things in common. The potassium pump mechanism, which is present on the plasma membrane of most cells, powers them all.
|Loperamide (ADL 2-1294)
|Methylnaltrexone bromide is a novel and potent μ-opioid antagonist.
|Naloxegol Oxalate (AZ13337019;AZ-13337019;NKTR118;NKTR-118; Movantik;PEGylated naloxol; Moventig), theOxalate salt of naloxegol which is the pegylated analog of α-naloxol,is a peripherally-acting and selective μ-opioid antagonist with anti-constipation effects.
|Naloxone HCl is an inverse opioid agonist drug used to counteract the effects of opiate overdose.
|Naltrexone HCl is a potentopioid receptor antagonist used mainly in the management of alcohol dependence and opioid dependence.
|Trimebutine Maleate (also known as Mebutin)is a potent agonist of peripheral mu, kappa and delta opiate receptors, it is used as spasmolytic agent for treatment of both acute and chronic abdominal pain.