GABA Receptor

GABA Receptor

Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.

GABA Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V71815 (E)-GABAB receptor antagonist 1 1611483-29-4 (E)-GABAB receptor antagonist 1 is the trans structure of GABAB receptor antagonist 1.
V70286 (S)-Cipepofol ((S)-Ciprofol; (S)-HSK3486) 1637741-59-3 (S)-Cipepofol is the inactive isomer of Cipepofol.
V70288 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) 4641-57-0 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a GABA analog that has sedative effects and can reduce exploratory behavior in rats at 50-100 mg/kg (intravenous injection).
V71853 12,14-Dichlorodehydroabietic acid 65281-77-8 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener.
V71812 17β-Estradiol sulfate sodium (17β-Estradiol 3-sulfate sodium) 4999-79-5 17β-Estradiol sulfate (sodium), known also as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid.
V71182 2'-O-Methylisoliquiritigenin 51828-10-5 2'-O-Methylisoliquiritigenin can be extracted from Arachis and can upregulate the 5-HT, NE, DA and GABA signaling pathways, but has little effect on the NE pathway.
V71844 2'MeO6MF 89112-85-6 2'MeO6MF is a BBB (blood-brain barrier) permeable (penetrable) PAM (positive allosteric modulator) of α2β1γ2L and all α1-containing GABAA receptors.
V71840 3-Aminopropylphosphinic acid (3-APPA; CGP 27492; CGA 147823) 103680-47-3 3-Aminopropylphosphinic acid (3-APPA) is a phosphate analog of GABA and a potent and specific GABAB receptor agonist (activator).
V85020 3-Aminopropylphosphonic acid ((3-Aminopropyl)phosphonic acid) 13138-33-5
V85426 3-Ethyl-3-methylthiolan-2-one 103620-92-4
V71817 3-Methyl-GABA 1216629-00-3 3-Methyl-GABA is a potent GABA aminotransferase activator.
V71811 3-Methylglutaconic acid (β-Methylglutaconic acid) 5746-90-7 3-Methylglutaconic acid is the major metabolite accumulated in 3-methylglutaric aciduria (MGTA).
V2709 4-Aminobutyric acid 56-12-2 Gamma-Aminobutyric Acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid)is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.
V70289 6-Aminonicotinic acid 3167-49-5 6-Aminonicotinic acid is a GABAA receptor agonist (activator) with Ki of 4.4 nM.
V71826 AA29504 945828-50-2 A29504 is an ethyl carbamate with gamma-aminobutyric acid (GABAA) receptor activity.
V71822 Acamprosate-d3 calcium 1225580-94-8 Acamprosate-d3 (calcium) is the deuterated form of Acamprosate calcium.
V71821 Acamprosate-d6 calcium 1225580-91-5 Acamprosate-d6 (calcium) is deuterium labelled Acamprosate calcium.
V71799 Afizagabar (S44819; Egis-13529) 1398496-82-6 Afizagabar (S44819) is a first-in-class, competitive, and selective α5-GABAAR antagonist (inhibitor) with IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2.
V28547 Afloqualone 56287-74-2 Afloqualone (HQ-495; HQ495; HQ 495) is a centrally acting muscle relaxant and an agonist of GABA receptor with sedative and muscle-relaxant effects.
V2878 Allopregnanolone 516-54-1 This product is discontinued due to commercial reason. Allopregnanolone [5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), or Brexanolone, zulresso and Allotetrahydroprogesterone] is a progesterone metabolite that serves as an allosteric modulator of theGABA (γ-aminobutyric acid) receptor.
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