The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76093 | (25S)-Antcin B | 1312711-71-9 | Antcin-B is a potent inhibitor of 3CLPro with high affinity. |
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V35118 | (Rac)-X77 | 2144491-78-9 | (Rac)-X77 is the racemate of X77. |
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V35040 | (±)-Alliin ((±)-L-Alliin) | 17795-26-5 | (±)-Alliin is the main active ingredient of garlic. |
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V54426 | 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent inhibitor of N protein and can be extracted from Curcuma kwangsiensis. |
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V54424 | 10-Hydroxyaloin A | 134863-91-5 | 10-Hydroxyaloin A is a potent SARS-CoV-2 inhibitor. |
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V52905 | 2-Hydroxyacetophenone (2-Hydroxyacetophenone; Phenacyl alcohol) | 582-24-1 | 2-Hydroxyacetophenone is the major root volatile of Carissa edulis. |
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V53006 | 2-Hydroxycinnamic acid ((E)-3-(2-hydroxyphenyl)acrylic acid) | 614-60-8 | 2-Hydroxycinnamic acid is extracted from the methanolic extract of cinnamon. |
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V79841 | Acryl42-10 | Acryl42-10 is a covalent/irreversible inhibitor of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 7 μM). | |
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V52436 | Adintrevimab (ADG 20) | 2516243-54-0 | Adintrevimab (ADG 20) is a human IgG1 monoclonal SARS-CoV (SARS-CoV) antibody. |
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V52427 | Alunacedase alfa (HrsACE2; GSK 2586881) | 2416824-55-8 | Alunacedase alfa (HrsACE2; GSK 2586881) is a human recombinant soluble angiotensin-converting enzyme 2 (hrsACE2). |
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V52736 | Amprenavir-d4 (Amprenavir-d4) | 1217661-20-5 | Amprenavir-d4 is the deuterium labelled form of Amprenavir. |
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V52418 | Amubarvimab (BRII-196) | 2509447-07-6 | Amubarvimab (BRII-196) is a human IgG1 mAb that binds to a non-competing epitope on the receptor-binding domain (RBD) of the spike protein with a KD of 5.88 nM. |
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V78030 | Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6) | Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6) is a humanized neutralizing antibody IgG1 (CHO expression system) that can compete for the binding of the viral Spike protein to the receptor (CD26), thereby inhibiting viral invasion. | |
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V78031 | Anti-MERS-3A1 mAb (MERS-3A1; MERS Antibody-3A1) | Anti-MERS-3A1 mAb (MERS-3A1) is a humanized monoclonal antibody (mAb) IgG1 with high binding affinity produced in CHO cells that can inhibit/disrupts the binding of MERS-CoV spike protein to the DPP4 receptor. | |
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V78032 | Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) | Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal antibody (mAb) IgG1 that directly binds to the DPP4 interaction region of the dimeric MERS-CoV Spike protein binding domain (RBD) and Neutralization is achieved by directly blocking receptor binding. | |
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V78058 | Anti-SARS-80R mAb (SARS-80R; SARS Antibody-80R) | Anti-SARS-80R mAb (SARS-80R) is a human monoclonal antibody (mAb) IgG1 produced in CHO cells. | |
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V78059 | Anti-SARS-CoV-2 Spike mAb (CR3022) (SARS-CR3022; SARS-CoV-2 Antibody-CR3022) | Anti-SARS-CoV-2 Spike mAb (CR3022) is a CHO cell-derived, human monoclonal antibody (mAb) IgG1 that binds to SARS-CoV/SARS-CoV-2 Spike protein (S1). | |
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V78060 | Anti-Spike-RBD mAb (SARS-CoV-2 (2019-nCoV) Spike RBD Antibody) | Anti-Spike-RBD mAb is a human monoclonal antibody (mAb) IgG1 derived from CHO cells, which can block the interaction between Spike protein and ACE2, thereby achieving the purpose of anti-SARS-CoV-2. | |
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V78061 | Anti-Spike-RBD Single Domain mAb (SARS-CoV-2 (2019-nCoV) Single-Domain Antibodies; Humanized Single Domain Antibody) | Anti-Spike-RBD Single Domain mAb is a CHO cell-derived alpaca monoclonal antibody (mAb) VHH-huFc that binds potently and specifically to the SARS-CoV-2 RBD. | |
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V78033 | Antimicrobial agent-10 | Antimicrobial agent-10 is a SARS-CoV-2 inhibitor (antagonist) with excellent anti-bacterial effect. |
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