The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76093 | (25S)-Antcin B | 1312711-71-9 | Antcin-B is a potent inhibitor of 3CLPro with high affinity. |
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V35118 | (Rac)-X77 | 2144491-78-9 | (Rac)-X77 is the racemate of X77. |
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V35040 | (±)-Alliin ((±)-L-Alliin) | 17795-26-5 | (±)-Alliin is the main active ingredient of garlic. |
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V91698 | 1"-α-Azido-RDPr | 1"-α-Azido-RDPr (Compound 11) is an adenosine diphosphate ribose analogue, which inhibits the SARS-CoV-2 nonstructural protein macromolecular domain SARS-CoV-2 NSP3 Mac1 with IC50 of 30 nM. | |
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V54426 | 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent inhibitor of N protein and can be extracted from Curcuma kwangsiensis. |
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V54424 | 10-Hydroxyaloin A | 134863-91-5 | 10-Hydroxyaloin A is a potent SARS-CoV-2 inhibitor. |
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V52905 | 2-Hydroxyacetophenone (2-Hydroxyacetophenone; Phenacyl alcohol) | 582-24-1 | 2-Hydroxyacetophenone is the major root volatile of Carissa edulis. |
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V53006 | 2-Hydroxycinnamic acid ((E)-3-(2-hydroxyphenyl)acrylic acid) | 614-60-8 | 2-Hydroxycinnamic acid is extracted from the methanolic extract of cinnamon. |
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V85492 | 28-O-Imidazolyl-azepano-betulin | ||
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V79841 | Acryl42-10 | Acryl42-10 is a covalent/irreversible inhibitor of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 7 μM). | |
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V52427 | Alunacedase alfa (HrsACE2; GSK 2586881) | 2416824-55-8 | Alunacedase alfa (HrsACE2; GSK 2586881) is a human recombinant soluble angiotensin-converting enzyme 2 (hrsACE2). |
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V52736 | Amprenavir-d4 (Amprenavir-d4) | 1217661-20-5 | Amprenavir-d4 is the deuterium labelled form of Amprenavir. |
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V78033 | Antimicrobial agent-10 | Antimicrobial agent-10 is a SARS-CoV-2 inhibitor (antagonist) with excellent anti-bacterial effect. | |
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V78034 | Antimicrobial agent-11 | Antimicrobial agent-11 is a SARS-CoV-2 inhibitor (antagonist) with antimicrobial effect. | |
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V78035 | Antimicrobial agent-12 | Antimicrobial agent-12 is an effective antimicrobial agent with SARS-CoV-2 inhibitory activity. | |
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V54433 | Antioxidant agent-9 | 71835-79-5 | Antioxidant agent-9 is a bioactive peptide with the sequence Asp-Trp. |
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V54427 | Antiviral agent 25 | 2761367-25-1 | antiviral compound 25 (compound 6g) is a new non-peptide mimetic covalent inhibitor of SARS-CoV-2 3CLpro. |
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V84450 | Antiviral agent 46 | 877660-90-7 | |
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V53358 | Antiviral agent 5 | 2698336-82-0 | antiviral compound 5 is an intermediate for antiviral active molecules targeting 3C and 3CL proteases like: SARS-CoV-2 Mpro. |
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V54394 | Arbemnifosbuvir | 1998705-63-7 | Arbemnifosbuvir is a nucleoviral RdRp-associated nucleotidyl transferase (NiRAN) nonstructural protein 12 (nsp12) interfering drug. |
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