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IDO

IDO

Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme which catalyzes the initial and rate limiting step in the degradation pathway of the essential amino acid tryptophan and is expressed in professional APCs, epithelial cells, vascular endothelium and tumor cellsIDO is a crucial enzyme in the initiation and spread of cancer. It encourages tumor angiogenesis, immune tolerance to tumor antigens in stromal and immune cells, suppression of T and NK cells, production and activation of T regulatory cells (Tregs), and myeloid-derived suppressor cells. It also supports inflammation in the tumor microenvironment.According to reports, functionally active IDO protein is expressed in a wide range of human hematologic malignancies, including breast cancer, colorectal cancer, endometrial cancer, gastric cancer, glioblastoma, gynecological cancers, head and neck cancers, non-small cell lung cancer (NSCLC), melanoma, and pancreatic cancer. The IDO pathway is emerging as a crucial method for the treatment of cancer as an immune checkpoint pathway.

IDO related products

Structure Cat No. Product Name CAS No. Product Description
(R)-IDO/TDO-IN-1 V73184 (R)-IDO/TDO-IN-1 2033173-00-9 (R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor (antagonist) with good pharmacokinetic properties.
(S)-Indoximod ((S)-NLG-8189) V51186 (S)-Indoximod ((S)-NLG-8189) 21339-55-9 (S)-Indoximod (1-Methyl-L-tryptophan) is an indoleamine-2,3-dioxygenase (IDO) inhibitor.
1-Isopropyltryptophan (1-IsoPT) V51717 1-Isopropyltryptophan (1-IsoPT) 1219485-46-7 1-Isopropyltryptophan (1-IsoPT) is an IDO1 inhibitor.
4-Phenyl-1H-1,2,3-triazole V51729 4-Phenyl-1H-1,2,3-triazole 1680-44-0 4-Phenyl-1H-1,2,3-triazole is an IDO1 inhibitor (IC50= 60 μM).
BMS-986242 V51724 BMS-986242 1923844-48-7 BMS-986242 is an orally bioactive, potent and specific inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1).
BMT-297376 V51718 BMT-297376 2251031-81-7 BMT-297376 is an optimized Linrodostat and a potent IDO1 inhibitor.
CAY-10581 V51720 CAY-10581 1018340-07-2 CAY10581, a pyranophanequinone analogue, is a specific and reversible noncompetitive IDO inhibitor (antagonist) with IC50 of 55 nM.
Coptisine chloride V18630 Coptisine chloride 6020-18-4 Coptisine chloride is an alkaloid extracted from Coptis chinensis.
DP-00477 V51723 DP-00477 169120-56-3 DP00477 is a potent IDO1 (indoleamine 2,3-dioxygenase 1) couple with IC50 of 7.0 µM.
IDO antagonist-1 V73187 IDO antagonist-1 2206797-88-6 IDO antagonist-1 (compound 163) is an antagonist of IDO.
IDO-IN-13 (GS4361) V37567 IDO-IN-13 (GS4361) 2291164-02-6 IDO-IN-13 (GS-4361), extracted from patent WO2019040102A1, example 43, is a novel and potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with EC50 of 17 nM.
IDO-IN-14 V51711 IDO-IN-14 2568302-02-1 IDO-IN-14 is an IDO inhibitor (antagonist) with IC50 of 0.6928 nM.
IDO-IN-15 V51710 IDO-IN-15 2433886-87-2 IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).
IDO-IN-18 V51708 IDO-IN-18 314027-92-4 IDO-IN-18 (Compound 00815) is an IDO inhibitor.
IDO1-IN-11 V51707 IDO1-IN-11 2306411-34-5 IDO1-IN-11 is an IDO1 inhibitor (antagonist) with IC50 of 0.6 nM.
IDO1-IN-12 V51706 IDO1-IN-12 2379570-48-4 IDO1-IN-12 is a potent and orally bioavailable IDO1 inhibitor.
IDO1-IN-21 V51705 IDO1-IN-21 2892432-98-1 IDO1-IN-21 (Compound 10m) is an IDO1 inhibitor (IC50 = 0.64 μM).
IDO1-IN-22 V73185 IDO1-IN-22 2126853-16-3 IDO1-IN-22 (Compound 3) is an IDO1 inhibitor (biochemical hIDO1 IC50= 67.4 nM, hIDO1 IC50 in HeLa cells: 17.6 nM).
IDO1-IN-22 V51709 IDO1-IN-22 IDO1-IN-22 (Compound 3) is an IDO1 inhibitor (biochemical hIDO1 IC50= 67.4 nM, hIDO1 IC50 in HeLa cells: 17.6 nM).
IDO1-IN-23 V79863 IDO1-IN-23 IDO1-IN-23 (compound 41) is a potent inhibitor of human IDO1 with IC50 of 13 μM.
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